CDH18 - cadherin 18 Gene

中文名称：钙粘蛋白 18

种属: Homo sapiens

同用名: CDH14; CDH24; CDH14L

关于 CDH18

功能概要

该基因编码一种 II 型经典钙粘蛋白，来自整合膜蛋白的钙粘蛋白超家族，介导钙依赖性细胞间粘附。成熟的钙粘蛋白由一个大的 N 末端胞外结构域、一个单一的跨膜结构域和一个小的、高度保守的 C 末端胞质结构域组成。 II 型 (非典型) 钙粘蛋白是根据它们缺乏 I 型钙粘蛋白特有的 HAV 细胞粘附识别序列来定义的。这种特殊的钙粘蛋白在中枢神经系统中特异表达，并被推定参与突触粘附、轴突生长和引导。已发现该基因编码不同亚型的可变剪接转录物变体。[RefSeq 提供，2014 年 5 月]

This gene encodes a type II classical cadherin from the cadherin superfamily of integral membrane proteins that mediate calcium-dependent cell-cell adhesion. Mature cadherin proteins are composed of a large N-terminal extracellular domain, a single membrane-spanning domain, and a small, highly conserved C-terminal cytoplasmic domain. Type II (atypical) Cadherins are defined based on their lack of a HAV cell adhesion recognition sequence specific to type I Cadherins. This particular cadherin is expressed specifically in the central nervous system and is putatively involved in synaptic adhesion, axon outgrowth and guidance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014]