MPZL2 - myelin protein zero like 2 Gene

中文名称：髓磷脂蛋白零样 2

种属: Homo sapiens

同用名: EVA; EVA1; DFNB111

关于 MPZL2

功能概要

胸腺发育取决于胸腺细胞和器官基质成分之间一系列复杂的相互作用。上皮 V 样抗原 (EVA) 在胸腺上皮细胞中表达，并受胸腺细胞发育进程的强烈下调。该基因在胚胎发生早期的胸腺和几种上皮结构中表达。它与髓鞘蛋白零高度同源，并且在胸腺衍生的上皮细胞系中，在非离子洗涤剂中溶解性差，强烈表明与细胞骨架有关。它通过嗜同性相互作用介导细胞粘附的能力及其通过 T 细胞成熟的选择性调节可能意味着 EVA 参与了胸腺器官发生的最早阶段。该蛋白具有一个特征性的 V 型结构域和胞外结构域中的两个潜在 N-糖基化位点；酪蛋白激酶 2 的假定丝氨酸磷酸化位点也存在于细胞质尾部。已发现该基因编码相同蛋白质的两个转录变体。[RefSeq 提供，2008 年 7 月]

Thymus development depends on a complex series of interactions between thymocytes and the stromal component of the organ. Epithelial V-like antigen (EVA) is expressed in thymus epithelium and strongly downregulated by thymocyte developmental progression. This gene is expressed in the thymus and in several epithelial structures early in embryogenesis. It is highly homologous to the myelin protein zero and, in thymus-derived epithelial cell lines, is poorly soluble in nonionic detergents, strongly suggesting an association to the Cytoskeleton. Its capacity to mediate cell adhesion through a homophilic interaction and its selective regulation by T cell maturation might imply the participation of EVA in the earliest phases of thymus organogenesis. The protein bears a characteristic V-type domain and two potential N-glycosylation sites in the extracellular domain; a putative serine phosphorylation site for Casein Kinase 2 is also present in the cytoplasmic tail. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]