2. Gene
  3. GPA33 - glycoprotein A33 Gene

GPA33 - glycoprotein A33 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：糖蛋白 A33

种属: Homo sapiens

同用名: A33

基因 ID: 10223 | 基因类型: protein coding

关于 GPA33

Cytogenetic location: 1q24.1 Genomic coordinates (GRCh38): 1:167,052,836-167,090,377 (from NCBI)

This gene has 4 transcripts (splice variants), 232 orthologues and 14 paralogues. Biased expression in colon (RPKM 108.1), duodenum (RPKM 69.2) and 2 other tissues.

功能概要

由该基因编码的糖蛋白是一种细胞表面抗原，在超过 95% 的人类结肠癌中都有表达。开放阅读框编码 319 个氨基酸的多肽，该多肽具有推定的分泌信号序列和 3 个潜在的糖基化位点。预测的成熟蛋白具有 213 个氨基酸的胞外区、一个跨膜结构域和一个 62 个氨基酸的胞内尾。细胞外区域的序列包含免疫球蛋白 (Ig) 超家族的 CD2 亚组特征的 2 个结构域。[RefSeq 提供，2008 年 7 月]

The glycoprotein encoded by this gene is a cell surface antigen that is expressed in greater than 95% of human colon cancers. The open reading frame encodes a 319-amino acid polypeptide having a putative secretory signal sequence and 3 potential glycosylation sites. The predicted mature protein has a 213-amino acid extracellular region, a single transmembrane domain, and a 62-amino acid intracellular tail. The sequence of the extracellular region contains 2 domains characteristic of the CD2 subgroup of the immunoglobulin (Ig) superfamily. [provided by RefSeq, Jul 2008]

GPA33 基因产物(1)

mRNA Protein Name
NM_005814.3 NP_005805.1 cell surface A33 antigen precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
21044950 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GPA33 蛋白结构

V-set

V-set: Immunoglobulin V-set domain (22 - 129)

Ig_2

Ig_2: Immunoglobulin domain (154 - 228)

  • 0
  • 100
  • 200
  • 300
  • 319 a.a.
蛋白主名 其他名称

cell surface A33 antigen

glycoprotein A33 (transmembrane)

GPA33 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GPA33 Q99795 POT1 Homo sapiens Q9NUX5
Pull Down
21044950
种属内
GPA33 Q99795 SMCO4 Homo sapiens Q9NRQ5
Validated Y2H
32296183
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GPA33 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70899 GPA33 Protein, Human (HEK293, His) Q99795 (I22-V235) ≥95%
HY-P78136 GPA33 Protein, Human (Biotinylated, HEK293, His-Avi) Q99795 (I22-V235) ≥95%
HY-P78450 GPA33 Protein, Human (HEK293, His-Avi) Q99795 (I22-V235) ≥95%

关联疾病

疾病名称 别名
Foodborne Botulism

Botulism

Botulism Poisoning

Intoxication With Clostridium Botulinum Toxin

Wound Botulism

Food Poisoning Due To Clostridium Botulinum

Infection Due To Clostridium Botulinum

Infant Botulism

Intoxication Botulism

Botulism, Infantile

Clostridium Botulinum Poisoning

Botulism Nos
Wound Botulism

Cutaneous Infectious Botulism

Cutaneous Toxin-Mediated Botulism

Inoculation Botulism

Skin Infectious Botulism

Skin Toxin-Mediated Botulism
Intestinal Botulism

Intestinal Colonization Botulism

Intestinal Toxemia Botulism

Intestinal Toxin-Mediated Botulism
Infant Botulism

Infant Intestinal Botulism

Infant Intestinal Toxemia Botulism

Infant Intestinal Toxin-Mediated Botulism

Infantile Botulism

Botulism, Infantile
Colorectal Cancer

Colon Cancer

Colorectal Carcinoma

Colon Carcinoma

Colorectal Cancer, Susceptibility To

Carcinoma Of Colon

CRC

Colorectal Cancer With Chromosomal Instability, Somatic

Colon Cancer, Somatic

Colon Cancer, Susceptibility To

Colonic Neoplasms

Colorectal Neoplasms

Colorectal Cancer, Somatic

Colon Cancer, Advanced, Somatic

Colonic Carcinoma

Colorectal Carcinomas

Colon Cancers

Colorectal Cancers

Cancer, Colorectal, Somatic

Cancer, Colon

Cancer, Colorectal, Susceptibility To

Colorectal Neoplasm

Colonic Neoplasm

Malignant Tumor Of Colon
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05613 GPA33 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus GPA33 VGNC VGNC:50186
Felis catus GPA33 VGNC VGNC:67400
Macaca mulatta GPA33 VGNC VGNC:106374
Canis familiaris GPA33 VGNC VGNC:53485
Mus musculus GPA33 MGD MGI:1891703
Rattus norvegicus GPA33 RGD RGD:1306711
Others GPA33 NCBI
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