2. Gene
  3. CAP1 - cyclase associated actin cytoskeleton regulatory protein 1 Gene

CAP1 - cyclase associated actin cytoskeleton regulatory protein 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：环化酶相关肌动蛋白细胞骨架调节蛋白 1

种属: Homo sapiens

同用名: CAP; CAP1-PEN

基因 ID: 10487 | 基因类型: protein coding

关于 CAP1

Cytogenetic location: 1p34.2 Genomic coordinates (GRCh38): 1:40,040,240-40,072,648 (from NCBI)

This gene has 19 transcripts (splice variants), 230 orthologues and 1 paralogue. Ubiquitous expression in appendix (RPKM 105.5), lymph node (RPKM 89.3) and 25 other tissues.

功能概要

该基因编码的蛋白质与酿酒酵母 CAP 蛋白有关，后者参与环 AMP 途径。人类蛋白质能够与同一蛋白质的其他分子以及 CAP2 和肌动蛋白相互作用。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2016 年 8 月]

The protein encoded by this gene is related to the S. cerevisiae CAP protein, which is involved in the cyclic AMP pathway. The human protein is able to interact with Other molecules of the same protein, as well as with CAP2 and actin. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2016]

CAP1 基因产物(14)

mRNA Protein Name
NM_001105530.2 NP_001099000.2 adenylyl cyclase-associated protein 1 isoform a
NM_001330502.2 NP_001317431.2 adenylyl cyclase-associated protein 1 isoform b
NM_001350475.2 NP_001337404.2 adenylyl cyclase-associated protein 1 isoform a
NM_001350476.2 NP_001337405.2 adenylyl cyclase-associated protein 1 isoform a
NM_001350477.3 NP_001337406.2 adenylyl cyclase-associated protein 1 isoform a
NM_001350478.2 NP_001337407.2 adenylyl cyclase-associated protein 1 isoform a
NM_001350479.2 NP_001337408.2 adenylyl cyclase-associated protein 1 isoform a
NM_001350480.2 NP_001337409.2 adenylyl cyclase-associated protein 1 isoform a
NM_001350481.2 NP_001337410.2 adenylyl cyclase-associated protein 1 isoform a
NM_001350482.2 NP_001337411.2 adenylyl cyclase-associated protein 1 isoform b
NM_001350483.2 NP_001337412.2 adenylyl cyclase-associated protein 1 isoform b
NM_001350484.2 NP_001337413.2 adenylyl cyclase-associated protein 1 isoform b
NM_001350485.2 NP_001337414.2 adenylyl cyclase-associated protein 1 isoform b
NM_006367.4 NP_006358.2 adenylyl cyclase-associated protein 1 isoform a

CAP1 蛋白结构

CAP_N

CAP_N: Adenylate cyclase associated (CAP) N terminal (4 - 305)

CAP_C

CAP_C: Adenylate cyclase associated (CAP) C terminal (317 - 473)

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  • 475 a.a.
蛋白主名 其他名称

adenylyl cyclase-associated protein 1

CAP, adenylate cyclase-associated protein 1

CAP1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属间
CAP1 Q01518 q2ghu2_ehrcr Ehrlichia chaffeensis Q2GHU2
Confocal
19273555
种属间
CAP1 Q01518 q2ghu2_ehrcr Ehrlichia chaffeensis Q2GHU2
Anti Tag CoIP
19273555
种属间
CAP1 Q01518 q2ghu2_ehrcr Ehrlichia chaffeensis Q2GHU2
Y2H Pooling
19273555
种属内
CAP1 Q01518 CFTR Homo sapiens P13569
Ub Reconstruction
35156780
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Anteroseptal Myocardial Infarction
Luminal Breast Carcinoma A

Breast Tumor Luminal

Luminal A Breast Carcinoma

Luminal Breast Cancer
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (15)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-145979 m7GpppUmpG / 否
HY-145980 m7GpppUpG / 否
HY-145981 m7GpppCpG / 否
HY-145982 m7GpppCmpG / 否
HY-164059 LZCap AG(3'Acm) mCherry mRNA / 否
HY-164188 m7(3'Ma-Cy5)Gppp(2'OMe)ApG ammonium / 否
HY-164189 m7(3'Ma-Cy3)Gppp(2'OMe)ApG ammonium / 否
HY-164190 m7(3'Ma-Biotin)Gppp(2'OMe)ApG ammonium / 否
HY-164191 m7(3'Ma-Peg5-FAM)Gppp(2'OMe)ApG ammonium / 否
HY-164192 m7(3'AcmG)(5')ppp(5')(2'OMeA)pG ammonium / 否
HY-164193 m7(3'AcmG)(5')ppp(5')(2'OMeA)pU ammonium / 否
HY-D0869S 3-(Cyclohexylamino)-1-propanesulfonic Acid-d17 / 否
HY-E70081 mRNA Cap 2'-O-methyltransferase / 否
HY-RS01880 CAP1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-164187 m7(3'Ma-Cy7)Gppp(2'OMe)ApG ammonium / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus CAP1 MGD MGI:88262
Rattus norvegicus CAP1 RGD RGD:620309
Felis catus CAP1 VGNC VGNC:60346
Bos taurus CAP1 VGNC VGNC:26737
Macaca mulatta CAP1 VGNC VGNC:99860
Others CAP1 NCBI
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