2. Gene
  3. SEMA4B - semaphorin 4B Gene

SEMA4B - semaphorin 4B Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：信号素 4B

种属: Homo sapiens

同用名: SemC; SEMAC

基因 ID: 10509 | 基因类型: protein coding

关于 SEMA4B

Cytogenetic location: 15q26.1 Genomic coordinates (GRCh38): 15:90,184,920-90,229,661 (from NCBI)

This gene has 20 transcripts (splice variants), 258 orthologues and 19 paralogues. Ubiquitous expression in esophagus (RPKM 24.0), skin (RPKM 20.0) and 25 other tissues.

功能概要

预测具有化学排斥活性和脑信号素受体结合活性。预计参与多个过程，包括神经元的生成；神经嵴细胞迁移；和脑信号蛋白-丛蛋白信号通路。预测位于质膜中。预计在细胞外空间活跃。预计是质膜的组成部分。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable chemorepellent activity and semaphorin receptor binding activity. Predicted to be involved in several processes, including generation of neurons; neural crest cell migration; and semaphorin-plexin signaling pathway. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]

SEMA4B 基因产物(8)

mRNA Protein Name
NM_001324029.3 NP_001310958.1 semaphorin-4B isoform 2
NM_001324030.3 NP_001310959.1 semaphorin-4B isoform 3
NM_001324031.4 NP_001310960.2 semaphorin-4B isoform 1 precursor
NM_001324032.3 NP_001310961.1 semaphorin-4B isoform 5 precursor
NM_001324034.3 NP_001310963.1 semaphorin-4B isoform 6 precursor
NM_001393916.1 NP_001380845.1 semaphorin-4B isoform 5 precursor
NM_020210.5 NP_064595.2 semaphorin-4B isoform 1 precursor
NM_198925.4 NP_945119.1 semaphorin-4B isoform 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
33845483 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SEMA4B 蛋白结构

Sema

Sema: Sema domain (71 - 504)

PSI

PSI: Plexin repeat (525 - 566)

  • 0
  • 200
  • 400
  • 600
  • 837 a.a.
蛋白主名 其他名称

semaphorin-4B

sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4B

重组 SEMA4B 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71284 Semaphorin-4B/SEMA4B Protein, Human (HEK293, His) Q9NPR2-1 (L44-E717) ≥95%

关联疾病

疾病名称 别名
Kallmann Syndrome

Hypogonadism With Anosmia

Kallman'S Syndrome

Anosmic Hypogonadism

Anosmic Idiopathic Hypogonadotropic Hypogonadism

Hypogonadotropic Hypogonadism And Anosmia

Hypogonadotropic Hypogonadism-Anosmia Syndrome

Olfacto-Genital Pathological Sequence

Familial Hypogonadism With Anosmia

Kallman Syndrome

Dysplasia Olfactogenitalis Of De Morsier

Kallmann'S Syndrome

Congenital Hypogonadotropic Hypogonadism With Anosmia
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12658 SEMA4B Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Felis catus SEMA4B VGNC VGNC:64993
Rattus norvegicus SEMA4B RGD RGD:1307872
Macaca mulatta SEMA4B VGNC VGNC:77165
Mus musculus SEMA4B MGD MGI:107559
Canis familiaris SEMA4B VGNC VGNC:45995
Bos taurus SEMA4B VGNC VGNC:34434
Others SEMA4B NCBI
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