2. Gene
  3. MYBBP1A - MYB binding protein 1a Gene

MYBBP1A - MYB binding protein 1a Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：MYB 结合蛋白 1a

种属: Homo sapiens

同用名: P160; PAP2; Pol5

基因 ID: 10514 | 基因类型: protein coding

关于 MYBBP1A

Cytogenetic location: 17p13.2 Genomic coordinates (GRCh38): 17:4,538,904-4,555,384 (from NCBI)

This gene has 13 transcripts (splice variants) and 204 orthologues. Ubiquitous expression in skin (RPKM 11.1), spleen (RPKM 9.9) and 25 other tissues.

功能概要

该基因编码一种核仁转录调节因子，该调节因子首先通过其特异性结合 Myb 原癌基因蛋白的能力得到鉴定。编码的蛋白质被认为在许多细胞过程中发挥作用，包括对核仁应激的反应、肿瘤抑制和核糖体 DNA 的合成。交替剪接导致多个转录本变体。[RefSeq 提供，2013 年 9 月]

This gene encodes a nucleolar transcriptional regulator that was first identified by its ability to bind specifically to the Myb proto-oncogene protein. The encoded protein is thought to play a role in many cellular processes including response to nucleolar stress, tumor suppression and synthesis of ribosomal DNA. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]

MYBBP1A 基因产物(2)

mRNA Protein Name
NM_001105538.2 NP_001099008.1 myb-binding protein 1A isoform 1
NM_014520.4 NP_055335.2 myb-binding protein 1A isoform 2
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular response to glucose starvation IDA
IDA: 通过直接分析推断
21471221 GOA
involved in intrinsic apoptotic signaling pathway by p53 class mediator IMP
IMP: 通过突变表型推断
21471221 GOA
involved in positive regulation of anoikis IMP
IMP: 通过突变表型推断
23388179 GOA
involved in positive regulation of transcription by RNA polymerase III IDA
IDA: 通过直接分析推断
16603771 GOA
acts upstream of negative effect regulation of G1 to G0 transition IMP
IMP: 通过突变表型推断
21471221 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of B-WICH complex IDA
IDA: 通过直接分析推断
16603771 GOA
located in nucleolus IDA
IDA: 通过直接分析推断
21471221 GOA
located in nucleus IDA
IDA: 通过直接分析推断
21471221 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

MYBBP1A 蛋白结构

DNA_pol_phi

DNA_pol_phi: DNA polymerase phi (70 - 836)

  • 0
  • 300
  • 600
  • 900
  • 1200
  • 1328 a.a.
蛋白主名 其他名称

myb-binding protein 1A

MYB binding protein (P160) 1a

关联疾病

疾病名称 别名
Charcot-Marie-Tooth Disease, X-Linked Recessive, 3

CMTX3

Charcot-Marie-Tooth Disease X-Linked Recessive 3

Charcot-Marie-Tooth Neuropathy, X-Linked Recessive, 3

Cmt3x

X-Linked Charcot-Marie-Tooth Disease Type 3

Charcot-Marie-Tooth Neuropathy X-Linked Recessive 3

Charcot-Marie-Tooth Disease, X-Linked Type 3, Recessive
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS08870 MYBBP1A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris MYBBP1A VGNC VGNC:43519
Macaca mulatta MYBBP1A VGNC VGNC:75090
Felis catus MYBBP1A VGNC VGNC:68370
Rattus norvegicus MYBBP1A RGD RGD:62062
Bos taurus MYBBP1A VGNC VGNC:31777
Mus musculus MYBBP1A MGD MGI:106181
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