2. Gene
  3. IGF2BP3 - insulin like growth factor 2 mRNA binding protein 3 Gene

IGF2BP3 - insulin like growth factor 2 mRNA binding protein 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：胰岛素样生长因子 2 mRNA 结合蛋白 3

种属: Homo sapiens

同用名: KOC; CT98; IMP3; KOC1; IMP-3; VICKZ3

基因 ID: 10643 | 基因类型: protein coding

关于 IGF2BP3

Cytogenetic location: 7p15.3 Genomic coordinates (GRCh38): 7:23,310,209-23,470,491 (from NCBI)

This gene has 18 transcripts (splice variants), 224 orthologues and 12 paralogues. Biased expression in placenta (RPKM 12.9), testis (RPKM 2.5) and 2 other tissues.

功能概要

由该基因编码的蛋白质主要存在于核仁中，在那里它可以与胰岛素样生长因子 II 前导 3 mRNA 的 5' UTR 结合，并可能在后期发育过程中抑制胰岛素样生长因子 II 的翻译。编码的蛋白质包含几个 KH 结构域，这些结构域在 RNA 结合中很重要，并且已知参与 RNA 合成和代谢。 7 号染色体上存在一个假基因，其他染色体上也存在假定的假基因。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is primarily found in the nucleolus, where it can bind to the 5' UTR of the insulin-like growth factor II leader 3 mRNA and may repress translation of insulin-like growth factor II during late development. The encoded protein contains several KH domains, which are important in RNA binding and are known to be involved in RNA synthesis and metabolism. A pseudogene exists on chromosome 7, and there are putative pseudogenes on other chromosomes. [provided by RefSeq, Jul 2008]

IGF2BP3 基因产物(1)

mRNA Protein Name
NM_006547.3 NP_006538.2 insulin-like growth factor 2 mRNA-binding protein 3
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables N6-methyladenosine-containing RNA reader activity IDA
IDA: 通过直接分析推断
29476152 GOA
enables mRNA 3'-UTR binding IDA
IDA: 通过直接分析推断
20080952 GOA
enables mRNA 5'-UTR binding IDA
IDA: 通过直接分析推断
9891060 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
17289661 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in CRD-mediated mRNA stabilization IDA
IDA: 通过直接分析推断
29476152 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in P-body IDA
IDA: 通过直接分析推断
29476152 GOA
located in cytoplasm IDA
IDA: 通过直接分析推断
9891060 GOA
located in cytoplasmic stress granule IDA
IDA: 通过直接分析推断
29476152 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

IGF2BP3 蛋白结构

(4 - 69)

RRM_1

RRM_1: RNA recognition motif. (a.k.a. RRM, RBD, or RNP domain) (85 - 150)

KH_1

KH_1: KH domain (198 - 260)

KH_1

KH_1: KH domain (280 - 343)

KH_1

KH_1: KH domain (408 - 469)

KH_1

KH_1: KH domain (490 - 553)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 500
  • 579 a.a.
蛋白主名 其他名称

insulin-like growth factor 2 mRNA-binding protein 3

IGF-II mRNA-binding protein 3

关联疾病

疾病名称 别名
Langerhans Cell Sarcoma

Malignant Langerhans Cell Sarcoma
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Barrett Esophagus

Barrett'S Esophagus

Barrett Esophagus/Esophageal Adenocarcinoma

Barrett Metaplasia

Barrett'S Ulcer Of Esophagus

Ulcerative Esophagitis

Barrett'S Esophagus With Esophagitis

Barrett'S Oesophagus

Barretts Syndrome

Barrett Syndrome

BE

Peptic Ulcer Of Esophagus

Adenocarcinoma Of Esophagus
Pilomyxoid Astrocytoma
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS06621 IGF2BP3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus IGF2BP3 VGNC VGNC:30081
Rattus norvegicus IGF2BP3 RGD RGD:1306512
Canis familiaris IGF2BP3 VGNC VGNC:41900
Macaca mulatta IGF2BP3 VGNC VGNC:73453
Felis catus IGF2BP3 VGNC VGNC:62890
Mus musculus IGF2BP3 MGD MGI:1890359
Others IGF2BP3 NCBI
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