CAMKK2 - calcium/calmodulin dependent protein kinase kinase 2 Gene

中文名称：钙/钙调蛋白依赖性蛋白激酶激酶 2

种属: Homo sapiens

同用名: CAMKK; CAMKKB

关于 CAMKK2

功能概要

该基因的产物属于丝氨酸/苏氨酸蛋白激酶家族，以及 CA (2+) /钙调蛋白依赖性蛋白激酶亚家族。该基因的主要亚型通过磷酸化下游激酶 CaMK1 和 CaMK4，在钙/钙调蛋白依赖性 (CaM) 激酶级联中发挥作用。该基因的蛋白质产物也磷酸化 AMP 活化蛋白激酶 (AMPK) 。该基因在大脑中表达最强，并影响涉及学习和记忆、神经元分化和迁移、神经突生长和突触形成的信号级联。可变剪接导致编码不同异构体的多个转录变体。已鉴定的亚型在进行自身磷酸化和磷酸化下游激酶的能力方面存在差异。[RefSeq 提供，2012 年 7 月]

The product of this gene belongs to the Serine/Threonine protein kinase family, and to the CA(2+)/calmodulin-dependent protein kinase subfamily. The major isoform of this gene plays a role in the calcium/calmodulin-dependent (CaM) kinase cascade by phosphorylating the downstream kinases CaMK1 and CaMK4. Protein products of this gene also phosphorylate AMP-activated protein kinase (AMPK). This gene has its strongest expression in the brain and influences signalling cascades involved with learning and memory, neuronal differentiation and migration, neurite outgrowth, and synapse formation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. The identified isoforms differ in their ability to undergo autophosphorylation and to phosphorylate downstream kinases. [provided by RefSeq, Jul 2012]