2. Gene
  3. SMPDL3A - sphingomyelin phosphodiesterase acid like 3A Gene

SMPDL3A - sphingomyelin phosphodiesterase acid like 3A Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：鞘磷脂磷酸二酯酶酸样 3A

种属: Homo sapiens

同用名: ASM3A; ASML3a; yR36GH4.1

基因 ID: 10924 | 基因类型: protein coding

关于 SMPDL3A

Cytogenetic location: 6q22.31 Genomic coordinates (GRCh38): 6:122,789,258-122,809,720 (from NCBI)

This gene has 3 transcripts (splice variants), 197 orthologues and 2 paralogues. Ubiquitous expression in colon (RPKM 18.5), small intestine (RPKM 18.4) and 25 other tissues.

功能概要

启用磷酸二酯水解酶活性和锌离子结合活性。参与核苷三磷酸分解代谢过程。位于细胞外空间。 [由基因组资源联盟提供，2022 年 4 月]

Enables phosphoric diester hydrolase activity and zinc ion binding activity. Involved in nucleoside triphosphate catabolic process. Located in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SMPDL3A 基因产物(2)

mRNA Protein Name
NM_001286138.2 NP_001273067.1 acid sphingomyelinase-like phosphodiesterase 3a isoform b
NM_006714.5 NP_006705.1 acid sphingomyelinase-like phosphodiesterase 3a isoform a precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables phosphoric diester hydrolase activity IDA
IDA: 通过直接分析推断
26783088 GOA
enables phosphoric diester hydrolase activity IMP
IMP: 通过突变表型推断
37890481 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
12442002 GOA
NOT enables sphingomyelin phosphodiesterase activity IDA
IDA: 通过直接分析推断
26783088 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
26783088 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of cGAS/STING signaling pathway IMP
IMP: 通过突变表型推断
37890481 GOA
involved in nucleoside triphosphate catabolic process IDA
IDA: 通过直接分析推断
26783088 GOA
NOT involved in sphingomyelin catabolic process IDA
IDA: 通过直接分析推断
26783088 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in extracellular space IDA
IDA: 通过直接分析推断
28104755 GOA
located in extracellular space IDA
IDA: 通过直接分析推断
25288789 GOA
is active in extracellular space IMP
IMP: 通过突变表型推断
37890481 GOA
located in extracellular space IMP
IMP: 通过突变表型推断
26783088 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SMPDL3A 蛋白结构

Metallophos

Metallophos: Calcineurin-like phosphoesterase (40 - 296)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 453 a.a.
蛋白主名 其他名称

acid sphingomyelinase-like phosphodiesterase 3a

0610010C24Rik

重组 SMPDL3A 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71325 SMPDL3A Protein, Human (HEK293, His) Q92484-1 (L23-Y453) ≥95%

关联疾病

疾病名称 别名
Polycystic Echinococcosis

Human Polycystic Hydatid Disease

Neotropical Echinococcosis
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS13451 SMPDL3A Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus SMPDL3A RGD RGD:1359277
Bos taurus SMPDL3A VGNC VGNC:35033
Felis catus SMPDL3A VGNC VGNC:65504
Mus musculus SMPDL3A MGD MGI:1931437
Macaca mulatta SMPDL3A VGNC VGNC:77731
Canis familiaris SMPDL3A VGNC VGNC:46573
Others SMPDL3A NCBI
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