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  3. GLIPR1 - GLI pathogenesis related 1 Gene

GLIPR1 - GLI pathogenesis related 1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：GLI 发病机制相关 1

种属: Homo sapiens

同用名: GLIPR; RTVP1; CRISP7

基因 ID: 11010 | 基因类型: protein coding

关于 GLIPR1

Cytogenetic location: 12q21.2 Genomic coordinates (GRCh38): 12:75,480,755-75,503,863 (from NCBI)

This gene has 4 transcripts (splice variants), 187 orthologues and 13 paralogues. Ubiquitous expression in appendix (RPKM 29.8), gall bladder (RPKM 25.1) and 24 other tissues.

功能概要

该基因编码的蛋白质与发病机制相关蛋白 (PR) 超家族和富含半胱氨酸的分泌蛋白 (CRISP) 家族都具有相似性。该基因的表达增加与巨噬细胞中的骨髓细胞分化相关，而通过基因甲基化降低该基因的表达与前列腺癌相关。该蛋白在前列腺和膀胱癌细胞中具有促凋亡活性。该基因是 12 号染色体上包含两个其他相似基因的簇的成员。已经描述了编码不同蛋白质同种型的可变剪接变体；然而，并非所有变体都得到了充分表征。[RefSeq 提供，2008 年 7 月]

This gene encodes a protein with similarity to both the pathogenesis-related protein (PR) superfamily and the cysteine-rich secretory protein (CRISP) family. Increased expression of this gene is associated with myelomocytic differentiation in macrophage and decreased expression of this gene through gene methylation is associated with prostate Cancer. The protein has proapoptotic activities in prostate and bladder Cancer cells. This gene is a member of a cluster on chromosome 12 containing two Other similar genes. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]

GLIPR1 基因产物(1)

mRNA Protein Name
NM_006851.3 NP_006842.2 glioma pathogenesis-related protein 1 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

GLIPR1 蛋白结构

CAP

CAP: Cysteine-rich secretory protein family (39 - 175)

  • 0
  • 100
  • 200
  • 266 a.a.
蛋白主名 其他名称

glioma pathogenesis-related protein 1

GLI pathogenesis-related 1 (glioma)

GLIPR1 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
GLIPR1 P48060 ALOXE3 Homo sapiens Q9BYJ1
Anti Tag CoIP
33961781
种属内
GLIPR1 P48060 ALOXE3 Homo sapiens Q9BYJ1
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 GLIPR1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P70359 GLIPR1 Protein, Human (HEK293, His) P48060-1 (A22-R232) ≥95%

关联疾病

疾病名称 别名
Glioma
D-Glyceric Aciduria

D-Glyceric Acidemia

D-Glycericacidemia

Glycerate Kinase Deficiency

D-Glycerate Kinase Deficiency

Non Ketotic Hyperglycinemia Syndrome

Deficiency Of Glycerate Kinase

Hyperglycinemia, Non-Ketotic

D-GA
Glioblastoma

Glioblastoma Multiforme

Gbm

Adult Glioblastoma Multiforme

Grade Iv Adult Astrocytic Tumor

Primary Glioblastoma Multiforme

Spongioblastoma Multiforme

Adult Glioblastoma

Primary Glioblastoma
Bladder Cancer

Urinary Bladder Cancer

Bladder Carcinoma

Urinary Bladder Carcinoma

Bladder Neoplasm

Bladder Tumor

Cancer, Bladder

Malignant Neoplasm Of Urinary Bladder

Carcinoma Of Bladder

Bladder Cancer, Somatic

Tumor Of The Bladder

Carcinoma Of Urinary Bladder

Bladder Carcinoma Urinary

Cancer Of The Urinary Bladder

Cancer, Urinary Bladder

Malignant Bladder Neoplasm

Malignant Bladder Tumor

Neoplasm Of The Bladder

Neoplasm Of The Urinary Bladder

Tumor Of The Urinary Bladder

Urinary Bladder Neoplasm

BLC

Urothelial Carcinoma Of The Bladder

Bladder Tumors

Urinary Bladder Neoplasms

Bladder Cancer Nos

Vesical Cancer Nos

Malignant Neoplasm Of Bladder, Part Unspecified

Malignant Tumour Of Urinary Bladder

Primary Malignant Neoplasm Of Bladder
Brain Cancer

Adult Brain Tumor

Malignant Neoplasm Of Brain

Brain Neoplasms

Brain Neoplasm

Neoplasm Of Brain

Primary Malignant Neoplasm Of Brain

Brain Tumors

Adult Malignant Brain Neoplasm

Brain Neoplasm, Adult

Bt - Brain Tumour

Malignant Brain Tumour

Malignant Primary Brain Neoplasm

Malignant Primary Brain Tumor

Malignant Tumor Of Adult Brain

Malignant Tumor Of Brain

Primary Brain Neoplasm

Primary Brain Tumor

Tumor Of The Brain

Brain Tumor, Adult

Brain Tumor Primary

Malignant Primary Brain Tumors

Primary Brain Tumors

Cancer, Brain

Brain Tumor, Primary
Prostate Cancer

Prostate Carcinoma

Prostate Cancer, Familial

Prostate Neoplasm

Prostate Cancer, Somatic

Prostate Cancer, Susceptibility To

Prostatic Cancer

Prostatic Neoplasms

Hereditary Prostate Cancer

Prostatic Neoplasm

Cancer Of Prostate

Carcinoma Of Prostate

Familial Prostate Cancer

Familial Prostate Carcinoma

Malignant Tumor Of Prostate

Malignant Neoplasm Of Prostate

Prostate Cancer, Familial, Susceptibility To

Malignant Tumor Of The Prostate

Ngp - New Growth Of Prostate

Tumor Of The Prostate

Prostate Cancer, Hereditary

Cancer Of The Prostate

Malignant Neoplasm Of The Prostate

Prostatic Carcinoma

PC

Prca

Cancer, Prostate

Malignant Prostatic Tumour

Malignant Tumour Of Prostate

Primary Prostate Cancer

Primary Malignant Neoplasm Of Prostate

Prostate Gland Cancer
Intellectual Developmental Disorder, X-Linked, Syndromic, Wilson-Turner Type

Wilson-Turner Syndrome

WTS

Mrxs6

X-Linked Intellectual Disability-Gynecomastia-Obesity Syndrome

Mrxswt

Wilson-Turner X-Linked Mental Retardation Syndrome

Mental Retardation, X-Linked, Syndromic 6

Mental Retardation, X-Linked, With Gynecomastia And Obesity

Intellectual Disability, X-Linked, Syndromic 6

Intellectual Disability, X-Linked, With Gynecomastia And Obesity

Wilson Turner Intellectual Disability Syndrome

X-Linked Intellectual Disability - Gynecomastia - Obesity
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05478 GLIPR1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta GLIPR1 VGNC VGNC:81411
Rattus norvegicus GLIPR1 RGD RGD:1305978
Mus musculus GLIPR1 MGD MGI:1920940
Felis catus GLIPR1 VGNC VGNC:84024
Bos taurus GLIPR1 VGNC VGNC:29402
Canis familiaris GLIPR1 VGNC VGNC:41260
Others GLIPR1 NCBI
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