LILRA3 - leukocyte immunoglobulin like receptor A3 Gene

中文名称：白细胞免疫球蛋白样受体 A3

种属: Homo sapiens

同用名: HM31; HM43; ILT6; LIR4; CD85E; ILT-6; LIR-4

关于 LILRA3

功能概要

该基因编码免疫受体家族的一个成员，该家族主要在单核细胞和 B 细胞中表达，在树突细胞和自然杀伤细胞中表达水平较低。编码的蛋白质缺乏在该家族其他成员中发现的跨膜区域。它充当 I 类主要组织相容性复合体 (MHC) 抗原的可溶性受体。已发现编码不同亚型的选择性剪接转录物变体。该基因位于 19 号染色体上的一组相关基因中，在人群中具有多态性，许多个体都包含该基因组区域的缺失。[RefSeq 提供，2014 年 3 月]

This gene encodes a member of a family of immunoreceptors that are expressed predominantly in monocytes and B cells, and at lower levels in dendritic cells and natural killer cells. The encoded protein lacks the transmembrane region found in Other members of this family. It acts as a soluble receptor for class I major histocompatibility complex (MHC) antigens. Alternatively spliced transcript variants encoding different isoforms have been found. This gene is located in a cluster of related genes on chromosome 19 and is polymorphic in human populations, with many individuals containing a deletion of this genomic region. [provided by RefSeq, Mar 2014]