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  3. Nr3c2 - nuclear receptor subfamily 3, group C, member 2 Gene

Nr3c2 - nuclear receptor subfamily 3, group C, member 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：核受体亚家族 3 ，C 组，成员 2

种属: Mus musculus

同用名: MR; Mlr

基因 ID: 110784 | 基因类型: protein coding

关于 Nr3c2

Chromosome 8: 77,626,070-77,971,641 forward strand.GRCm39:CM001001.3

This gene has 8 transcripts (splice variants), 213 orthologues, 8 paralogues and is associated with 23 phenotypes. Broad expression in colon adult (RPKM 12.), frontal lobe adult (RPKM 3.4) and 2 other tissues.

功能概要

该基因编码的蛋白可启动类固醇结合活动。参与突触后膜电位的调节和突触小泡胞吐的调节。作用于细胞钠离子稳态和排泄的上游或内部。位于 GABA 能突触。在谷氨酸能突触中活跃。在几个结构中表达，包括中枢神经系统和泌尿生殖系统。用于研究 1 型常染色体显性假性醛固酮减退症。该基因的人类直系同源物涉及常染色体显性假性醛固酮减退症 1 型和假性醛固酮减少症。与人 NR3C2（核受体亚家族 3 C 组成员 2）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables steroid binding activity. Involved in regulation of postsynaptic membrane potential and regulation of synaptic vesicle exocytosis. Acts upstream of or within cellular sodium ion homeostasis and excretion. Located in GABA-ergic synapse. Is active in glutamatergic synapse. Is expressed in several structures, including central nervous system and genitourinary system. Used to study autosomal dominant pseudohypoaldosteronism type 1. Human ortholog(s) of this gene implicated in autosomal dominant pseudohypoaldosteronism type 1 and pseudohypoaldosteronism. Orthologous to human NR3C2 (nuclear receptor subfamily 3 group C member 2). [provided by Alliance of Genome Resources, Apr 2022]

Nr3c2 基因产物(1)

mRNA Protein Name
NM_001083906.2 NP_001077375.1 mineralocorticoid receptor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
11809749 MGI
enables steroid binding IDA
IDA: 通过直接分析推断
11809749 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in angiotensin-activated signaling pathway IMP
IMP: 通过突变表型推断
24206662 MGI
acts upstream of or within intracellular sodium ion homeostasis IMP
IMP: 通过突变表型推断
9689096 MGI
involved in potassium ion homeostasis IMP
IMP: 通过突变表型推断
24206662 MGI
involved in presynaptic modulation of chemical synaptic transmission EXP
EXP: 通过实验结果推断
18547242 MGI
involved in presynaptic modulation of chemical synaptic transmission IDA
IDA: 通过直接分析推断
18547242 MGI
involved in regulation of blood volume by renal aldosterone IMP
IMP: 通过突变表型推断
24206662 MGI
involved in regulation of postsynaptic membrane potential EXP
EXP: 通过实验结果推断
18547242 MGI
involved in regulation of postsynaptic membrane potential IDA
IDA: 通过直接分析推断
18547242 MGI
involved in regulation of potassium:proton exchanging ATPase activity IDA
IDA: 通过直接分析推断
24206662 MGI
acts upstream of or within renal sodium excretion IMP
IMP: 通过突变表型推断
9689096 MGI
involved in signal transduction IMP
IMP: 通过突变表型推断
24206662 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in GABA-ergic synapse EXP
EXP: 通过实验结果推断
18547242 MGI
is active in GABA-ergic synapse IDA
IDA: 通过直接分析推断
18547242 MGI
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
18547242 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
18547242 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Nr3c2 蛋白结构

Herpes_BLLF1

Herpes_BLLF1: cl37540 (199 - 393)

NR_DBD_GR_PR

NR_DBD_GR_PR: cd07172 (598 - 672)

NR_LBD_MR

NR_LBD_MR: cd07075 (732 - 979)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 980 a.a.
蛋白主名 其他名称

mineralocorticoid receptor

aldosterone receptor

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09547 NR3C2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09548 Nr3c2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09549 Nr3c2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Nr3c2 NCBI NCBI:4306
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