1. Gene
  2. ADCY8 - adenylate cyclase 8 Gene

ADCY8 - adenylate cyclase 8 Gene

中文名称:腺苷酸环化酶 8

种属: Homo sapiens

同用名: AC8; ADCY3; HBAC1

基因 ID: 114 | 基因类型: protein coding

关于 ADCY8

Cytogenetic location: 8q24.22 Genomic coordinates (GRCh38): 8:130,780,301-131,040,909 (from NCBI)

This gene has 3 transcripts (splice variants), 197 orthologues and 17 paralogues. Biased expression in brain (RPKM 4.1), lung (RPKM 0.8) and 2 other tissues.

功能概要

腺苷酸环化酶是一种膜结合酶,可催化 ATP 形成环状 AMP。酶活性受几种激素的控制,不同的多肽参与信号从受体到催化部分的转导。刺激性或抑制性受体 (Rs 和 Ri) 与表现出 GTP 酶活性的 G 蛋白 (Gs 和 Gi) 相互作用,它们调节腺苷酸环化酶催化亚基的活性[RefSeq 提供,2008 年 7 月]

Adenylate Cyclase is a membrane bound Enzyme that catalyses the formation of cyclic AMP from ATP. The enzymatic activity is under the control of several Hormones, and different polypeptides participate in the transduction of the signal from the receptor to the catalytic moiety. Stimulatory or inhibitory receptors (Rs and Ri) interact with G proteins (Gs and Gi) that exhibit GTPase activity and they modulate the activity of the catalytic subunit of the adenylyl cyclase [provided by RefSeq, Jul 2008]

ADCY8 基因产物(1)

mRNA Protein Name
NM_001115.3 NP_001106.1 adenylate cyclase type 8

ADCY8 蛋白结构

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (406 - 588)

DUF1053

DUF1053: Domain of Unknown Function (DUF1053) (618 - 712)

Guanylate_cyc

Guanylate_cyc: Adenylate and Guanylate cyclase catalytic domain (974 - 1171)

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  • 1251 a.a.
蛋白主名 其他名称

adenylate cyclase type 8

ATP pyrophosphate-lyase 8

关联疾病

疾病名称 别名
Dissociative Amnesia

Psychogenic Amnesia

Amnesia, Dissociative

Amnesia, Psychogenic

Amnesia Neurosis

Hysterical Fugue

Dissociative Fugue

Joubert Syndrome 24

JBTS24

Nemaline Myopathy 7

NEM7

Nemaline Myopathy 7, Autosomal Recessive

Cfl2-Related Nemaline Myopathy

Myopathy, Nemaline, Type 7

Dissociative Disorder

Dissociative Disorders

Dissociative Disease

Dissociative Reaction

疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

直系同源

种属 基因名 来源 基因 ID
Mus musculus ADCY8 MGD MGI:1341110
Canis familiaris ADCY8 VGNC VGNC:37625
Felis catus ADCY8 VGNC VGNC:59621
Rattus norvegicus ADCY8 RGD RGD:2036
Macaca mulatta ADCY8 VGNC VGNC:69516
Bos taurus ADCY8 VGNC VGNC:25649