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  3. P2rx2 - purinergic receptor P2X 2 Gene

P2rx2 - purinergic receptor P2X 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：嘌呤能受体 P2 X 2

种属: Rattus norvegicus

同用名: P2X2

基因 ID: 114115 | 基因类型: protein coding

关于 P2rx2

Primary_assembly 12: 46,339,549-46,342,891 forward strand.mRatBN7.2:CM026985.1

This gene has 3 transcripts (splice variants), 190 orthologues, 6 paralogues and is associated with 4 phenotypes. Biased expression in Testes (RPKM 23.9), Uterus (RPKM 1.3) and 7 other tissues.

功能概要

该基因编码的蛋白可启动多项功能，包括 ATP 绑定活动；细胞外 ATP 门控阳离子通道活性；和过渡金属离子结合活性。涉及多个过程，包括神经元动作电位；突触前细胞溶质钙离子浓度的调节；和对缺血的反应。位于多个细胞成分中，包括树突棘；突触后密度；和突触前膜。是膜的组成部分。受体复合体的一部分。在谷氨酸能突触中活跃。是突触前活动区膜的组成部分。该基因的人类直系同源物与常染色体显性非综合征性耳聋 41 相关。与人类 P2RX2（嘌呤能受体 P2X 2）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and transition metal ion binding activity. Involved in several processes, including neuronal action potential; regulation of presynaptic cytosolic calcium ion concentration; and response to ischemia. Located in several cellular components, including dendritic spine; postsynaptic density; and presynaptic membrane. Is integral component of membrane. Part of receptor complex. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 41. Orthologous to human P2RX2 (purinergic receptor P2X 2). [provided by Alliance of Genome Resources, Apr 2022]

P2rx2 基因产物(2)

mRNA Protein Name
NM_053656.3 NP_446108.2 P2X purinoceptor 2
NM_053656.3 NP_446108.2 P2X purinoceptor 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
16190872 RGD
enables cadmium ion binding IDA
IDA: 通过直接分析推断
16190872 RGD
enables cobalt ion binding IDA
IDA: 通过直接分析推断
16190872 RGD
enables copper ion binding IDA
IDA: 通过直接分析推断
16190872 RGD
enables extracellularly ATP-gated monoatomic cation channel activity IDA
IDA: 通过直接分析推断
16190872 RGD
enables extracellularly ATP-gated monoatomic cation channel activity IMP
IMP: 通过突变表型推断
15317863 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15313628 RGD
enables ligand-gated monoatomic ion channel activity IDA
IDA: 通过直接分析推断
7542879 RGD
enables mercury ion binding IDA
IDA: 通过直接分析推断
16190872 RGD
enables nickel cation binding IDA
IDA: 通过直接分析推断
16190872 RGD
enables phosphatidylinositol binding IMP
IMP: 通过突变表型推断
16857707 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
16330549 RGD
enables protein-containing complex binding IDA
IDA: 通过直接分析推断
15313628 RGD
enables purinergic nucleotide receptor activity IDA
IDA: 通过直接分析推断
16388598 RGD
enables suramin binding IDA
IDA: 通过直接分析推断
16388598 RGD
enables zinc ion binding IDA
IDA: 通过直接分析推断
16190872 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in neuronal action potential IDA
IDA: 通过直接分析推断
16190872 RGD
involved in neuronal action potential IMP
IMP: 通过突变表型推断
15317863 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration EXP
EXP: 通过实验结果推断
16000618 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IDA
IDA: 通过直接分析推断
16000618 RGD
involved in regulation of presynaptic cytosolic calcium ion concentration IEP
IEP: 通过表达模式推断
16000618 RGD
involved in regulation of synaptic vesicle exocytosis EXP
EXP: 通过实验结果推断
16000618 RGD
involved in regulation of synaptic vesicle exocytosis IDA
IDA: 通过直接分析推断
16000618 RGD
involved in regulation of synaptic vesicle exocytosis IEP
IEP: 通过表达模式推断
16000618 RGD
involved in response to ischemia IMP
IMP: 通过突变表型推断
12849743 RGD
involved in response to organic cyclic compound IDA
IDA: 通过直接分析推断
16388598 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in Schaffer collateral - CA1 synapse IDA
IDA: 通过直接分析推断
16330549 RGD
located in cell surface IDA
IDA: 通过直接分析推断
18616429 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
11160443 RGD
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
16000618 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
11160443 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
10974431 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: 通过直接分析推断
11160443 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
15313628 RGD
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
11160443 RGD
is active in presynaptic active zone membrane IDA
IDA: 通过直接分析推断
16000618 RGD
located in presynaptic membrane IDA
IDA: 通过直接分析推断
10974431 RGD
part of receptor complex IDA
IDA: 通过直接分析推断
15313628 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
10974431 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2rx2 蛋白结构

P2X

P2X: TIGR00863 (13 - 391)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 497 a.a.
蛋白主名 其他名称

P2X purinoceptor 2

ATP receptor

purinergic receptor P2X, ligand-gated ion channel, 2

P2rx2 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
P2rx2 P49653 P2rx6 Rattus norvegicus P51579
IF
24815693
种属内
P2rx2 P49653 P2rx4 Rattus norvegicus P51577
IF
24815693
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09900 P2RX2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09901 P2rx2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09902 P2rx2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens P2rx2 NCBI NCBI:22953
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