P2rx2 - purinergic receptor P2X 2 Gene

中文名称：嘌呤能受体 P2 X 2

种属: Rattus norvegicus

同用名: P2X2

关于 P2rx2

功能概要

该基因编码的蛋白可启动多项功能，包括 ATP 绑定活动；细胞外 ATP 门控阳离子通道活性；和过渡金属离子结合活性。涉及多个过程，包括神经元动作电位；突触前细胞溶质钙离子浓度的调节；和对缺血的反应。位于多个细胞成分中，包括树突棘；突触后密度；和突触前膜。是膜的组成部分。受体复合体的一部分。在谷氨酸能突触中活跃。是突触前活动区膜的组成部分。该基因的人类直系同源物与常染色体显性非综合征性耳聋 41 相关。与人类 P2RX2（嘌呤能受体 P2X 2）直系同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; extracellularly ATP-gated cation channel activity; and transition metal ion binding activity. Involved in several processes, including neuronal action potential; regulation of presynaptic cytosolic calcium ion concentration; and response to ischemia. Located in several cellular components, including dendritic spine; postsynaptic density; and presynaptic membrane. Is integral component of membrane. Part of receptor complex. Is active in glutamatergic synapse. Is integral component of presynaptic active zone membrane. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 41. Orthologous to human P2RX2 (purinergic receptor P2X 2). [provided by Alliance of Genome Resources, Apr 2022]