2. Gene
  3. P2rx4 - purinergic receptor P2X 4 Gene

P2rx4 - purinergic receptor P2X 4 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：嘌呤能受体 P2 X 4

种属: Rattus norvegicus

基因 ID: 29659 | 基因类型: protein coding

关于 P2rx4

Primary_assembly 12: 33,844,396-33,862,253 reverse strand.mRatBN7.2:CM026985.1

This gene has 4 transcripts (splice variants), 211 orthologues, 6 paralogues and is associated with 5 phenotypes. Biased expression in Spleen (RPKM 179.), Kidney (RPKM 171.7) and 9 other tissues.

功能概要

该基因编码的蛋白可启动多项功能，包括 ATP 绑定活动；配体门控阳离子通道活性；和过渡金属离子结合活性。参与多个过程，包括细胞对锌离子的反应；神经元动作电位；和小胶质细胞迁移的正调节。位于多个细胞成分中，包括树突棘；神经细胞体；和突触后密度。是质膜的组成部分。充血性心力衰竭的生物标志物。与人 P2RX4（嘌呤能受体 P2X 4）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables several functions, including ATP binding activity; ligand-gated cation channel activity; and transition metal ion binding activity. Involved in several processes, including cellular response to zinc ion; neuronal action potential; and positive regulation of microglial cell migration. Located in several cellular components, including dendritic spine; neuronal cell body; and postsynaptic density. Is integral component of plasma membrane. Biomarker of congestive heart failure. Orthologous to human P2RX4 (purinergic receptor P2X 4). [provided by Alliance of Genome Resources, Apr 2022]

P2rx4 基因产物(1)

mRNA Protein Name
NM_031594.2 NP_113782.2 P2X purinoceptor 4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables ATP binding IDA
IDA: 通过直接分析推断
12819199 RGD
enables ATP-gated ion channel activity IDA
IDA: 通过直接分析推断
24817123 RGD
enables copper ion binding IDA
IDA: 通过直接分析推断
12819199 RGD
enables extracellularly ATP-gated monoatomic cation channel activity IDA
IDA: 通过直接分析推断
8551329 RGD
enables identical protein binding IPI
IPI: 通过物理相互作用推断
15313628 RGD
enables ligand-gated calcium channel activity IMP
IMP: 通过突变表型推断
17299767 RGD
enables protein binding IPI
IPI: 通过物理相互作用推断
24815693 RGD
enables purinergic nucleotide receptor activity IDA
IDA: 通过直接分析推断
12819199 RGD
enables signaling receptor binding IPI
IPI: 通过物理相互作用推断
17785580 RGD
enables zinc ion binding IDA
IDA: 通过直接分析推断
12819199 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in behavioral response to pain IMP
IMP: 通过突变表型推断
12917686 RGD
involved in calcium ion transmembrane transport IDA
IDA: 通过直接分析推断
8551329 RGD
involved in cellular response to ATP IDA
IDA: 通过直接分析推断
8551329 RGD
involved in cellular response to zinc ion IDA
IDA: 通过直接分析推断
8551329 RGD
involved in inorganic cation transmembrane transport IDA
IDA: 通过直接分析推断
16282518 RGD
involved in neuronal action potential IDA
IDA: 通过直接分析推断
12819199 RGD
involved in positive regulation of microglial cell migration IMP
IMP: 通过突变表型推断
17299767 RGD
involved in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IMP
IMP: 通过突变表型推断
17299767 RGD
involved in regulation of chemotaxis IMP
IMP: 通过突变表型推断
17299767 RGD
NOT involved in regulation of ruffle assembly IMP
IMP: 通过突变表型推断
17299767 RGD
involved in regulation of sodium ion transport IDA
IDA: 通过直接分析推断
17785580 RGD
involved in response to axon injury IMP
IMP: 通过突变表型推断
12917686 RGD
involved in response to ischemia IMP
IMP: 通过突变表型推断
12849743 RGD
involved in sensory perception of pain IMP
IMP: 通过突变表型推断
12917686 RGD
involved in sensory perception of touch IMP
IMP: 通过突变表型推断
12917686 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
15476696 RGD
located in cell body IDA
IDA: 通过直接分析推断
12849743 RGD
located in dendrite IDA
IDA: 通过直接分析推断
15476696 RGD
located in dendritic spine IDA
IDA: 通过直接分析推断
11160443 RGD
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
11160443 RGD
located in lysosomal membrane IDA
IDA: 通过直接分析推断
24817123 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
11160443 RGD
is active in parallel fiber to Purkinje cell synapse IDA
IDA: 通过直接分析推断
11160443 RGD
located in plasma membrane IDA
IDA: 通过直接分析推断
17785580 RGD
located in plasma membrane IMP
IMP: 通过突变表型推断
8551329 RGD
is active in postsynaptic density membrane IDA
IDA: 通过直接分析推断
11160443 RGD
located in terminal bouton IDA
IDA: 通过直接分析推断
15476696 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2rx4 蛋白结构

P2X_receptor

P2X_receptor: pfam00864 (12 - 360)

  • 0
  • 100
  • 200
  • 300
  • 388 a.a.
蛋白主名 其他名称

P2X purinoceptor 4

ATP receptor

P2X4

purinergic receptor P2X, ligand-gated ion channel 4

P2rx4 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
P2rx4 P51577 P2rx2 Rattus norvegicus P49653
Anti Tag CoIP
24815693
种属内
P2rx4 P51577 P2rx4 Rattus norvegicus P51577
Comig Non-Denat Gel
19419241
种属内
P2rx4 P51577 P2rx6 Rattus norvegicus P51579
IF
24815693
种属内
P2rx4 P51577 P2rx6 Rattus norvegicus P51579
Anti Tag CoIP
24815693
种属内
P2rx4 P51577 P2rx4 Rattus norvegicus P51577
AFM
19419241
种属间: 跨种属相互作用 种属内: 同种属相互作用

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09906 P2RX4 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09907 P2rx4 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS09908 P2rx4 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens P2rx4 NCBI NCBI:5025
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