P2RX4 - purinergic receptor P2X 4 Gene

中文名称：嘌呤能受体 P2X 4

种属: Homo sapiens

同用名: P2X4; P2X4R

基因 ID: 5025 | 基因类型: protein coding

关于 P2RX4

Cytogenetic location: 12q24.31 Genomic coordinates (GRCh38): 12:121,210,129-121,234,106 (from NCBI)

This gene has 13 transcripts (splice variants), 211 orthologues and 6 paralogues. Ubiquitous expression in placenta (RPKM 18.6), colon (RPKM 15.4) and 25 other tissues.

功能概要

该基因的产物属于 ATP 嘌呤受体家族。该受体充当具有高钙渗透性的配体门控离子通道。嘌呤受体家族成员之间的主要药理学区别是对拮抗剂苏拉明和 PPADS 的相对敏感性。该基因的产物对这些拮抗剂的敏感性最低。已发现该基因的多个选择性剪接转录物变体，一些编码蛋白质，一些不编码蛋白质。[RefSeq 提供，2012 年 2 月]

The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel with high calcium permeability. The main pharmacological distinction between the members of the purinoceptor family is the relative sensitivity to the antagonists suramin and PPADS. The product of this gene has the lowest sensitivity for these antagonists. Multiple alternatively spliced transcript variants, some protein-coding and some not protein-coding, have been found for this gene. [provided by RefSeq, Feb 2012]

P2RX4 基因产物(11)

mRNA	Protein	Name
NM_001261397.2	NP_001248326.1	P2X purinoceptor 4 isoform 3
XM_047428911.1	XP_047284867.1	P2X purinoceptor 4 isoform X3
NR_046372.2
XM_011538416.3	XP_011536718.1	P2X purinoceptor 4 isoform X2
XM_047428910.1	XP_047284866.1	P2X purinoceptor 4 isoform X1
NM_001261398.2	NP_001248327.1	P2X purinoceptor 4 isoform 4
NR_046373.2
NM_175568.1
NM_175567.1
NM_001256796.2	NP_001243725.1	P2X purinoceptor 4 isoform 1
NM_002560.3	NP_002551.2	P2X purinoceptor 4 isoform 2

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables cadherin binding	IPI IPI: 通过物理相互作用推断	12088286	GOA
enables extracellularly ATP-gated monoatomic cation channel activity	IDA IDA: 通过直接分析推断	9016352	GOA
enables identical protein binding	IPI IPI: 通过物理相互作用推断	9016352	GOA
enables ligand-gated calcium channel activity	IDA IDA: 通过直接分析推断	9016352	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	25416956	GOA
enables purinergic nucleotide receptor activity	IDA IDA: 通过直接分析推断	9016352	GOA
enables purinergic nucleotide receptor activity	IMP IMP: 通过突变表型推断	11606481	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in apoptotic signaling pathway	IDA IDA: 通过直接分析推断	17264311	GOA
involved in calcium ion transmembrane transport	IDA IDA: 通过直接分析推断	9016352	GOA
involved in cellular response to ATP	IDA IDA: 通过直接分析推断	10515189	GOA
involved in membrane depolarization	IDA IDA: 通过直接分析推断	9016352	GOA
involved in monoatomic ion transmembrane transport	IDA IDA: 通过直接分析推断	10515189	GOA
involved in negative regulation of cardiac muscle hypertrophy	IMP IMP: 通过突变表型推断	15130891	GOA
involved in positive regulation of blood vessel endothelial cell migration	IMP IMP: 通过突变表型推断	21106936	GOA
involved in positive regulation of calcium ion transport into cytosol	IDA IDA: 通过直接分析推断	10969036	GOA
involved in positive regulation of calcium ion transport into cytosol	IMP IMP: 通过突变表型推断	10899068	GOA
involved in positive regulation of calcium-mediated signaling	IDA IDA: 通过直接分析推断	10969036	GOA
involved in positive regulation of calcium-mediated signaling	IMP IMP: 通过突变表型推断	10899068	GOA
involved in positive regulation of endothelial cell chemotaxis	IMP IMP: 通过突变表型推断	21106936	GOA
involved in purinergic nucleotide receptor signaling pathway	IMP IMP: 通过突变表型推断	11606481	GOA
involved in regulation of blood pressure	IMP IMP: 通过突变表型推断	11606481	GOA
involved in regulation of cardiac muscle contraction	IMP IMP: 通过突变表型推断	11606481	GOA
involved in relaxation of cardiac muscle	IMP IMP: 通过突变表型推断	11606481	GOA
involved in response to ATP	IDA IDA: 通过直接分析推断	9016352	GOA
involved in response to fluid shear stress	IDA IDA: 通过直接分析推断	10969036	GOA
involved in signal transduction	IDA IDA: 通过直接分析推断	9016352	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cell junction	IDA IDA: 通过直接分析推断	12088286	GOA
located in lysosomal membrane	IDA IDA: 通过直接分析推断	9016352	GOA
located in membrane	IDA IDA: 通过直接分析推断	17785580	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	12088286	GOA
located in plasma membrane	IDA IDA: 通过直接分析推断	23303206	GOA
located in plasma membrane	IMP IMP: 通过突变表型推断	10515189	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

P2RX4 蛋白结构

P2X_receptor

0
100
200
300
388 a.a.

蛋白主名

其他名称

P2X purinoceptor 4

ATP receptor	ATP-gated cation channel protein
P2X receptor, subunit 4	purinergic receptor P2X, ligand gated ion channel, 4
purinergic receptor P2X4	purinoceptor P2X4

P2RX4 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	P2RX4	Q99571	KRTAP12-3	Homo sapiens	P60328	Y2H Array	32296183
种属内	P2RX4	Q99571	KRTAP12-3	Homo sapiens	P60328	Y2H Prey Pooling	32296183
种属内	P2RX4	Q99571	KRTAP1-1	Homo sapiens	Q07627	Y2H Array	32296183
种属内	P2RX4	Q99571	KRTAP1-1	Homo sapiens	Q07627	Y2H Prey Pooling	32296183
种属内	P2RX4	Q99571	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Array	32296183
种属内	P2RX4	Q99571	NOTCH2NLC	Homo sapiens	P0DPK4	Y2H Prey Pooling	32296183
种属内	P2RX4	Q99571	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Prey Pooling	25416956
种属内	P2RX4	Q99571	NOTCH2NLA	Homo sapiens	Q7Z3S9	Y2H Array	25416956

种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称

别名

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Migraine With Or Without Aura 1

Migraine	Migraine With Or Without Aura, Susceptibility To, 1
Migraine Disorder	Migraine Variant
Migraines	Migraine Disorders
Mgr1	Mgau
Ma	Migraine With Or Without Aura
Classic Migraine	Common Migraine
Disorder, Migraine	Headache Migraine
Headache Migrainous	Migraine Headache
Migraine Syndrome	Headache Including Migraine
Migraine, Susceptibility To

Paine Syndrome

Pain Disorder	Pain
Microcephaly With Spastic Diplegia	Pain Syndrome

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS09906	P2RX4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS09907	P2rx4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	否
HY-RS09908	P2rx4 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Felis catus	P2RX4	VGNC	VGNC:68671
Canis familiaris	P2RX4	VGNC	VGNC:44210
Mus musculus	P2RX4	MGD	MGI:1338859
Macaca mulatta	P2RX4	VGNC	VGNC:75734
Rattus norvegicus	P2RX4	RGD	RGD:62073
Bos taurus	P2RX4	VGNC	VGNC:32520

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

P2RX4 - purinergic receptor P2X 4 Gene

关于 P2RX4

功能概要

P2RX4 基因产物(11)

P2RX4 蛋白结构

P2RX4 蛋白互作信息

关联疾病

直系同源

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P2RX4 - purinergic receptor P2X 4 Gene

关于 P2RX4

功能概要

P2RX4 基因产物(11)

P2RX4 蛋白结构

P2RX4 蛋白互作信息

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z