SORCS1 - sortilin related VPS10 domain containing receptor 1 Gene

中文名称：含 sortilin 相关 VPS10 域受体 1

种属: Homo sapiens

同用名: hSorCS

关于 SORCS1

功能概要

该基因编码一个包含液泡蛋白分选 10 (VPS10) 结构域的受体蛋白家族成员。 VPS10 域名来源于酵母羧肽酶 Y 分选受体 Vps10 蛋白。这个基因家族的成员很大，有很多外显子，但 CDS 长度通常小于 3700 nt。非常大的内含子通常将编码 VPS10 域的外显子分开；其余的外显子被更小的内含子隔开。这些基因在中枢神经系统中强烈表达。五个家族成员中的两个 (sortilin 和 sortilin 相关受体) 被合成为前原蛋白；目前尚不清楚这种编码的蛋白质是否也是前原蛋白。已经鉴定出编码不同亚型的选择性剪接转录物变体。[RefSeq 提供，2008 年 7 月]

This gene encodes one family member of vacuolar protein sorting 10 (VPS10) domain-containing Receptor Proteins. The VPS10 domain name comes from the yeast Carboxypeptidase Y sorting receptor Vps10 protein. Members of this gene family are large with many exons but the CDS lengths are usually less than 3700 nt. Very large introns typically separate the exons encoding the VPS10 domain; the remaining exons are separated by much smaller-sized introns. These genes are strongly expressed in the central nervous system. Two of the five family members (sortilin and sortilin-related receptor) are synthesized as preproproteins; it is not yet known if this encoded protein is also a preproprotein. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]