1. Gene
  2. Adam10 - a disintegrin and metallopeptidase domain 10 Gene

Adam10 - a disintegrin and metallopeptidase domain 10 Gene

中文名称:解整合素和金属肽酶结构域 10

种属: Mus musculus

同用名: kuz; MADM; kuzbanian; 1700031C13Rik

基因 ID: 11487 | 基因类型: protein coding

关于 Adam10

Chromosome 9: 70,586,279-70,687,511 forward strand.GRCm39:CM001002.3

This gene has 4 transcripts (splice variants), 371 orthologues, 35 paralogues and is associated with 16 phenotypes. Ubiquitous expression in liver E14 (RPKM 28.), liver E14.5 (RPKM 23.2) and 27 other tissues.

功能概要

该基因编码内切蛋白酶去整合素和金属蛋白酶 (ADAM) 家族的成员,这些内切蛋白酶在各种生物过程中发挥重要作用,包括细胞信号传导、粘附和迁移。编码的前原蛋白经过蛋白水解处理以产生成熟的酶,该酶在称为胞外域脱落的过程中参与膜结合蛋白的蛋白水解释放。缺乏编码蛋白的小鼠死于子宫,并伴有发育中的中枢神经系统、体节和心血管系统的多种缺陷。 [RefSeq 提供,2016 年 5 月]

This gene encodes a member of a disintegrin and metalloprotease (ADAM) family of endoproteases that play important roles in various biological processes including cell signaling, adhesion and migration. The encoded preproprotein undergoes proteolytic processing to generate a mature Enzyme that is involved in the proteolytic release of membrane-bound proteins in a process called ectodomain shedding. Mice lacking the encoded protein die in utero with multiple defects of the developing central nervous system, somites, and cardiovascular system. [provided by RefSeq, May 2016]

Adam10 基因产物(1)

mRNA Protein Name
NM_007399.4 NP_031425.2 disintegrin and metalloproteinase domain-containing protein 10 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables endopeptidase activity IDA
IDA: 通过直接分析推断
12794186 MGI
enables endopeptidase activity IMP
IMP: 通过突变表型推断
29325091 MGI
enables metallodipeptidase activity IMP
IMP: 通过突变表型推断
14993236 MGI
enables metallopeptidase activity IDA
IDA: 通过直接分析推断
14761956 MGI
enables metallopeptidase activity IMP
IMP: 通过突变表型推断
12354787 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
12176995 MGI
enables protein homodimerization activity IPI
IPI: 通过物理相互作用推断
12176995 MGI
enables protein kinase binding IDA
IDA: 通过直接分析推断
12176995 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in Notch signaling pathway IMP
IMP: 通过突变表型推断
12354787 MGI
involved in adherens junction organization IMP
IMP: 通过突变表型推断
30639848 MGI
involved in cochlea development IMP
IMP: 通过突变表型推断
30639848 MGI
involved in epidermal growth factor receptor ligand maturation IMP
IMP: 通过突变表型推断
14993236 MGI
involved in in utero embryonic development IMP
IMP: 通过突变表型推断
12354787 MGI
involved in membrane protein ectodomain proteolysis IDA
IDA: 通过直接分析推断
17245433 MGI
involved in membrane protein ectodomain proteolysis IMP
IMP: 通过突变表型推断
29325091 MGI
involved in pore complex assembly IMP
IMP: 通过突变表型推断
30463011 MGI
involved in postsynapse organization EXP
EXP: 通过实验结果推断
21123580 MGI
involved in postsynapse organization IDA
IDA: 通过直接分析推断
21123580 MGI
involved in protein catabolic process at postsynapse EXP
EXP: 通过实验结果推断
23083742 MGI
involved in protein catabolic process at postsynapse IDA
IDA: 通过直接分析推断
23083742 MGI
involved in protein catabolic process at postsynapse IEP
IEP: 通过表达模式推断
23083742 MGI
involved in protein catabolic process at postsynapse IMP
IMP: 通过突变表型推断
23083742 MGI
involved in protein phosphorylation IDA
IDA: 通过直接分析推断
12176995 MGI
acts upstream of or within protein processing IDA
IDA: 通过直接分析推断
20383322 MGI
involved in regulation of Notch signaling pathway IMP
IMP: 通过突变表型推断
29397483 MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane EXP
EXP: 通过实验结果推断
21123580 MGI
involved in regulation of neurotransmitter receptor localization to postsynaptic specialization membrane IDA
IDA: 通过直接分析推断
21123580 MGI
involved in regulation of postsynapse organization EXP
EXP: 通过实验结果推断
23083742 MGI
involved in regulation of postsynapse organization IDA
IDA: 通过直接分析推断
23083742 MGI
involved in regulation of postsynapse organization IEP
IEP: 通过表达模式推断
23083742 MGI
involved in regulation of postsynapse organization IMP
IMP: 通过突变表型推断
23083742 MGI
involved in regulation of vasculature development IMP
IMP: 通过突变表型推断
29397483 MGI
involved in signaling receptor ligand precursor processing IMP
IMP: 通过突变表型推断
14993236 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cell surface IDA
IDA: 通过直接分析推断
28032533 MGI
located in cytoplasm IDA
IDA: 通过直接分析推断
12176995 MGI
is active in glutamatergic synapse EXP
EXP: 通过实验结果推断
21123580 MGI
is active in glutamatergic synapse IDA
IDA: 通过直接分析推断
21123580 MGI
is active in glutamatergic synapse IEP
IEP: 通过表达模式推断
23083742 MGI
is active in glutamatergic synapse IMP
IMP: 通过突变表型推断
23083742 MGI
located in nucleus IDA
IDA: 通过直接分析推断
12176995 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
29325091 MGI
is active in plasma membrane IMP
IMP: 通过突变表型推断
14993236 MGI
part of pore complex IMP
IMP: 通过突变表型推断
30463011 MGI
located in postsynaptic density IDA
IDA: 通过直接分析推断
17301176 MGI
located in synaptic membrane IDA
IDA: 通过直接分析推断
23676497 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

Adam10 蛋白结构

Pep_M12B_propep

Pep_M12B_propep: cl03265 (45 - 155)

ZnMc_TACE_like

ZnMc_TACE_like: cd04270 (220 - 459)

DISIN

DISIN: smart00050 (466 - 545)

  • 0
  • 200
  • 400
  • 600
  • 749 a.a.
蛋白主名 其他名称

disintegrin and metalloproteinase domain-containing protein 10

a disintegrin and metalloprotease domain (ADAM) 10

kuzbanian protein homolog

mammalian disintegrin-metalloprotease

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Adam10 NCBI NCBI:102