Adora1 - adenosine A1 receptor Gene

中文名称：腺苷 A1 受体

种属: Mus musculus

同用名: Ri; A1R; A1AR; AA1R; ARA1; A1-AR

关于 Adora1

功能概要

预计该基因编码的蛋白具有多种功能，包括 G 蛋白偶联腺苷受体活性； G蛋白β/γ-亚基复合物结合活性；和异源三聚体 G 蛋白结合活性。参与调节疼痛的感官知觉。作用于多个过程的上游或内部，包括兴奋性突触后电位；长期突触抑制的负调节；和粘液分泌的负调节。位于树突棘。以多种结构表达，包括脂肪组织；消化系统；脑;泌尿生殖系统；和心。该基因的人类直系同源物与哮喘有关。与人类 ADORA1（腺苷 A1 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable several functions, including G protein-coupled Adenosine Receptor activity; G-protein beta/gamma-subunit complex binding activity; and heterotrimeric G-protein binding activity. Involved in regulation of sensory perception of pain. Acts upstream of or within several processes, including excitatory postsynaptic potential; negative regulation of long-term synaptic depression; and negative regulation of mucus secretion. Located in dendritic spine. Is expressed in several structures, including adipose tissue; alimentary system; brain; genitourinary system; and heart. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA1 (adenosine A1 receptor). [provided by Alliance of Genome Resources, Apr 2022]