2. Gene
  3. Adora2a - adenosine A2a receptor Gene

Adora2a - adenosine A2a receptor Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：腺苷 A2 a受体

种属: Mus musculus

同用名: A2aR; A2AAR; AA2AR; ARA2A

基因 ID: 11540 | 基因类型: protein coding

关于 Adora2a

Chromosome 10: 75,152,711-75,170,618 forward strand.GRCm39:CM001003.3

This gene has 4 transcripts (splice variants), 263 orthologues, 3 paralogues and is associated with 42 phenotypes. Broad expression in thymus adult (RPKM 8.8), spleen adult (RPKM 8.) and 26 other tissues.

功能概要

该基因编码的蛋白可启动 G 蛋白偶联腺苷受体活性。作用于多个过程的上游或内部，包括 G 蛋白偶联受体信号通路；化学突触传递；和细胞通讯的积极调节。位于质膜。以多种结构表达，包括大脑；泌尿生殖系统；淋巴系统腺体；肠;以及肝脏和胆道系统。用于研究近视和原发性肺动脉高压。该基因的人类直系同源物与哮喘有关。与人类 ADORA2A（腺苷 A2a 受体）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables G protein-coupled Adenosine Receptor activity. Acts upstream of or within several processes, including G protein-coupled receptor signaling pathway; chemical synaptic transmission; and positive regulation of cell communication. Located in plasma membrane. Is expressed in several structures, including brain; genitourinary system; hemolymphoid system gland; intestine; and liver and biliary system. Used to study myopia and primary pulmonary hypertension. Human ortholog(s) of this gene implicated in asthma. Orthologous to human ADORA2A (adenosine A2a receptor). [provided by Alliance of Genome Resources, Apr 2022]

Adora2a 基因产物(6)

mRNA Protein Name
NM_009630.3 NP_033760.2 adenosine receptor A2a
NM_001331095.1 NP_001318024.1 adenosine receptor A2a
NM_001331096.1 NP_001318025.1 adenosine receptor A2a
NM_001331095.1 NP_001318024.1 adenosine receptor A2a
NM_001331096.1 NP_001318025.1 adenosine receptor A2a
NM_009630.3 NP_033760.2 adenosine receptor A2a
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables G protein-coupled adenosine receptor activity IDA
IDA: 通过直接分析推断
8157966 MGI
enables G protein-coupled adenosine receptor activity IMP
IMP: 通过突变表型推断
10845921 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within G protein-coupled adenosine receptor signaling pathway IDA
IDA: 通过直接分析推断
12223546 MGI
involved in G protein-coupled adenosine receptor signaling pathway IDA
IDA: 通过直接分析推断
8157966 MGI
acts upstream of or within G protein-coupled adenosine receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
12223546 MGI
acts upstream of or within G protein-coupled adenosine receptor signaling pathway IMP
IMP: 通过突变表型推断
10845921 MGI
acts upstream of or within G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
11404425 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
8738226 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
IGI: 通过遗传相互作用推断
12223546 MGI
acts upstream of or within adenylate cyclase-activating G protein-coupled receptor signaling pathway IMP
IMP: 通过突变表型推断
10845921 MGI
acts upstream of apoptotic signaling pathway IMP
IMP: 通过突变表型推断
10845921 MGI
acts upstream of or within eating behavior IGI
IGI: 通过遗传相互作用推断
12538862 MGI
acts upstream of or within inhibitory postsynaptic potential IGI
IGI: 通过遗传相互作用推断
10704492 MGI
acts upstream of or within locomotory behavior IGI
IGI: 通过遗传相互作用推断
10908627 MGI
acts upstream of or within negative regulation of alpha-beta T cell activation IDA
IDA: 通过直接分析推断
10069416 MGI
acts upstream of or within negative regulation of inflammatory response IGI
IGI: 通过遗传相互作用推断
17601796 MGI
acts upstream of or within positive regulation of apoptotic signaling pathway IMP
IMP: 通过突变表型推断
10845921 MGI
acts upstream of or within positive regulation of synaptic transmission, GABAergic IDA
IDA: 通过直接分析推断
10934242 MGI
acts upstream of or within positive regulation of synaptic transmission, GABAergic IGI
IGI: 通过遗传相互作用推断
10934242 MGI
acts upstream of or within response to amphetamine IMP
IMP: 通过突变表型推断
11172060 MGI
acts upstream of or within synaptic transmission, dopaminergic IGI
IGI: 通过遗传相互作用推断
12538862 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in membrane IDA
IDA: 通过直接分析推断
8738226 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
12817016 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Adora2a 蛋白结构

7tmA_Adenosine_R_A2A

7tmA_Adenosine_R_A2A: cd15068 (3 - 293)

7tmA_Adenosine_R_A2A

7tmA_Adenosine_R_A2A: cd15068 (4 - 30)

7tmA_Adenosine_R_A2A

7tmA_Adenosine_R_A2A: cd15068 (37 - 64)

7tmA_Adenosine_R_A2A

7tmA_Adenosine_R_A2A: cd15068 (73 - 103)

7tmA_Adenosine_R_A2A

7tmA_Adenosine_R_A2A: cd15068 (117 - 135)

7tmA_Adenosine_R_A2A

7tmA_Adenosine_R_A2A: cd15068 (168 - 198)

7tmA_Adenosine_R_A2A

7tmA_Adenosine_R_A2A: cd15068 (220 - 250)

7tmA_Adenosine_R_A2A

7tmA_Adenosine_R_A2A: cd15068 (261 - 286)

  • 0
  • 100
  • 200
  • 300
  • 410 a.a.
蛋白主名 其他名称

adenosine receptor A2a

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00394 ADORA2A Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00395 Adora2a Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00396 Adora2a Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Adora2a NCBI NCBI:135
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