Agtr2 - angiotensin II receptor, type 2 Gene

中文名称：血管紧张素 II 受体，2 型

种属: Mus musculus

关于 Agtr2

功能概要

该基因编码的蛋白可启动血管紧张素 II 型受体活性。参与多个过程，包括G蛋白偶联受体信号通路偶联cGMP核苷酸第二信使；后肾发育；和参与输尿管芽形态发生的分枝的正调控。在参与全身动脉血压调节的血管紧张素介导的血管舒张作用的上游或内部起作用；脑肾素-血管紧张素系统；和炎症反应。预测位于细胞质的核周区。预计在质膜上有活性。以多种结构表达，包括消化系统；脑;胚外成分；泌尿生殖系统；和肢体。与 IgA 肾小球肾炎有关的该基因的人类直系同源物；晚期肾脏疾病;低血糖;智力残疾;和膀胱输尿管反流。与人类 AGTR2（血管紧张素 II 受体 2 型）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables angiotensin type II receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway coupled to cGMP nucleotide second messenger; metanephros development; and positive regulation of branching involved in ureteric bud morphogenesis. Acts upstream of or within angiotensin-mediated vasodilation involved in regulation of systemic arterial blood pressure; brain renin-angiotensin system; and inflammatory response. Predicted to be located in perinuclear region of cytoplasm. Predicted to be active in plasma membrane. Is expressed in several structures, including alimentary system; brain; extraembryonic component; genitourinary system; and limb. Human ortholog(s) of this gene implicated in IgA glomerulonephritis; end stage renal disease; hypoglycemia; intellectual disability; and vesicoureteral reflux. Orthologous to human AGTR2 (angiotensin II receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]