2. Gene
  3. Aldh1a1 - aldehyde dehydrogenase family 1, subfamily A1 Gene

Aldh1a1 - aldehyde dehydrogenase family 1, subfamily A1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：醛脱氢酶 家族 1 ，亚家族 A1

种属: Mus musculus

同用名: E1; Ahd2; Ahd-2; Aldh1; ALHDII; Raldh1; ALDH-E1; Aldh1a2

基因 ID: 11668 | 基因类型: protein coding

关于 Aldh1a1

Chromosome 19: 20,470,079-20,620,829 forward strand.GRCm39:CM001012.3

This gene has 6 transcripts (splice variants), 200 orthologues, 19 paralogues and is associated with 2 phenotypes. Biased expression in liver adult (RPKM 141.6), genital fat pad adult (RPKM 125.) and 12 other tissues.

功能概要

该基因编码的蛋白可启动 3-氯烯丙基醛脱氢酶活性和氨基丁醛脱氢酶活性。参与γ-氨基丁酸生物合成过程和冷诱导产热的负调节。在几个过程的上游或内部起作用，包括相机型眼睛发育中涉及的视杯形态发生；凋亡过程的正调控；和维甲酸代谢过程。位于轴突和突触。以多种结构表达，包括消化系统；泌尿生殖系统；神经系统;呼吸系统;和感觉器官。与人类 ALDH1A1（醛脱氢酶 1 家族成员 A1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 3-chloroallyl aldehyde dehydrogenase activity and aminobutyraldehyde dehydrogenase activity. Involved in gamma-aminobutyric acid biosynthetic process and negative regulation of cold-induced thermogenesis. Acts upstream of or within several processes, including optic cup morphogenesis involved in camera-type eye development; positive regulation of apoptotic process; and retinoid metabolic process. Located in axon and synapse. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ALDH1A1 (aldehyde dehydrogenase 1 family member A1). [provided by Alliance of Genome Resources, Apr 2022]

Aldh1a1 基因产物(5)

mRNA Protein Name
NM_001361505.1 NP_001348434.1 aldehyde dehydrogenase 1A1
NM_001361503.1 NP_001348432.1 aldehyde dehydrogenase 1A1
NM_013467.4 NP_038495.2 aldehyde dehydrogenase 1A1
NM_001361504.1 NP_001348433.1 aldehyde dehydrogenase 1A1
NM_001361506.1 NP_001348435.1 aldehyde dehydrogenase 1A1
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3-chloroallyl aldehyde dehydrogenase activity IDA
IDA: 通过直接分析推断
12610736 MGI
enables aminobutyraldehyde dehydrogenase (NAD+) activity IMP
IMP: 通过突变表型推断
26430123 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within 9-cis-retinoic acid biosynthetic process IDA
IDA: 通过直接分析推断
11876656 MGI
acts upstream of apoptotic process IGI
IGI: 通过遗传相互作用推断
16207763 MGI
acts upstream of or within embryonic eye morphogenesis IGI
IGI: 通过遗传相互作用推断
16207763 MGI
involved in fructose catabolic process IDA
IDA: 通过直接分析推断
4343087 MGI
involved in gamma-aminobutyric acid biosynthetic process IMP
IMP: 通过突变表型推断
26430123 MGI
involved in negative regulation of cold-induced thermogenesis IMP
IMP: 通过突变表型推断
22561685 MGI
acts upstream of or within optic cup morphogenesis involved in camera-type eye development IGI
IGI: 通过遗传相互作用推断
16611695 MGI
acts upstream of or within positive regulation of apoptotic process IGI
IGI: 通过遗传相互作用推断
16207763 MGI
acts upstream of or within response to xenobiotic stimulus IDA
IDA: 通过直接分析推断
18971422 MGI
acts upstream of or within retinoic acid metabolic process IDA
IDA: 通过直接分析推断
10191271 MGI
acts upstream of or within retinoic acid metabolic process IGI
IGI: 通过遗传相互作用推断
16207763 MGI
acts upstream of or within retinoic acid metabolic process IMP
IMP: 通过突变表型推断
12808103 MGI
acts upstream of or within retinol metabolic process IMP
IMP: 通过突变表型推断
12851412 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in axon IDA
IDA: 通过直接分析推断
26430123 MGI
located in synapse IDA
IDA: 通过直接分析推断
26430123 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Aldh1a1 蛋白结构

ALDH_F1AB_F2_RALDH1

ALDH_F1AB_F2_RALDH1: cd07141 (14 - 494)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 501 a.a.
蛋白主名 其他名称

aldehyde dehydrogenase 1A1

3-deoxyglucosone dehydrogenase

RALDH 1

alcohol dehydrogenase family 1, subfamily A1

alcohol dehydrogenase family 1, subfamily A2

aldehyde dehydrogenase 1, liver cytosolic (class 1)

aldehyde dehydrogenase family 1 member A1

aldehyde dehydrogenase, cytosolic

retinal dehydrogenase 1

相关产品

Pre-clinical Phase
生物活性分子 (26)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-138097 α-NETA ≥98.0% 否
HY-18768 NCT-501 Inhibitor 99.84% 否
HY-148466 IGUANA-1 Inhibitor 98.88% 否
HY-112278 NCT-506 Inhibitor 99.95% 否
HY-135841 CM010 Inhibitor 98.07% 否
HY-123621 GNE-375 Inhibitor 99.81% 否
HY-112277 NCT-505 Inhibitor 98.41% 否
HY-146683 KS106 99.31% 否
HY-110294 CM037 Inhibitor 99.06% 否
HY-146682 KS100 99.61% 否
HY-126003 ALDH1A1-IN-2 Inhibitor 99.31% 否
HY-122912 ALDH1A inhibitor 673A 98.81% 否
HY-148243 IGUANA-1 free base Inhibitor 99.69% 否
HY-157567 FSI-TN42 Inhibitor 98.05% 否
HY-125085 ALDH3A1-IN-3 Inhibitor 99.30% 否
HY-146240 ALDH1A1-IN-3 Inhibitor / 否
HY-155816 PROTAC NSD3 degrader-1 / 否
HY-157872 ALDH1A1-IN-4 Inhibitor / 否
HY-158026 ALDH1A1-IN-5 Inhibitor / 否
HY-159111 KS124 / 否
HY-18768A NCT-501 hydrochloride Inhibitor / 否
HY-RS00560 ALDH1A1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00561 Aldh1a1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00562 ALDH1A1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00565 ALDH1B1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00566 ALDH1L1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Aldh1a1 NCBI NCBI:216
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z