2. Gene
  3. Aldh3a1 - aldehyde dehydrogenase family 3, subfamily A1 Gene

Aldh3a1 - aldehyde dehydrogenase family 3, subfamily A1 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：醛脱氢酶 家族 3 ，亚家族 A1

种属: Mus musculus

同用名: Ahd4; Aldh; Ahd-4; Aldh3

基因 ID: 11670 | 基因类型: protein coding

关于 Aldh3a1

Chromosome 11: 61,098,363-61,109,247 forward strand.GRCm39:CM001004.3

This gene has 3 transcripts (splice variants), 370 orthologues, 19 paralogues and is associated with 1 phenotype. Biased expression in bladder adult (RPKM 55.3), stomach adult (RPKM 53.6) and 1 other tissue.

功能概要

该基因编码的蛋白可启动 3-氯烯丙基醛脱氢酶活性和醛脱氢酶 (NAD+) 活性。预计将参与多个过程，包括对 cAMP 的响应；对糖皮质激素的反应；和对缺氧的反应。位于细胞质中。是膜的组成部分。以多种结构表达，包括消化系统；蜕膜;早孕;性腺;和肝脏。该基因的人类直系同源物与动脉硬化有关。与人类 ALDH3A1（醛脱氢酶 3 家族成员 A1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables 3-chloroallyl aldehyde dehydrogenase activity and aldehyde dehydrogenase (NAD+) activity. Predicted to be involved in several processes, including response to cAMP; response to glucocorticoid; and response to hypoxia. Located in cytoplasm. Is integral component of membrane. Is expressed in several structures, including alimentary system; decidua; early conceptus; gonad; and liver. Human ortholog(s) of this gene implicated in arteriosclerosis. Orthologous to human ALDH3A1 (aldehyde dehydrogenase 3 family member A1). [provided by Alliance of Genome Resources, Apr 2022]

Aldh3a1 基因产物(3)

mRNA Protein Name
NM_007436.2 NP_031462.2 aldehyde dehydrogenase, dimeric NADP-preferring isoform 1
NM_001112725.1 NP_001106196.1 aldehyde dehydrogenase, dimeric NADP-preferring isoform 1
NM_001331112.1 NP_001318041.1 aldehyde dehydrogenase, dimeric NADP-preferring isoform 2
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables 3-chloroallyl aldehyde dehydrogenase activity IDA
IDA: 通过直接分析推断
742739 MGI
enables 3-chloroallyl aldehyde dehydrogenase activity IMP
IMP: 通过突变表型推断
11784860 MGI
enables aldehyde dehydrogenase (NAD+) activity IDA
IDA: 通过直接分析推断
25286108 MGI
enables oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor IDA
IDA: 通过直接分析推断
10376761 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytoplasm IDA
IDA: 通过直接分析推断
25286108 MGI
located in membrane IDA
IDA: 通过直接分析推断
25286108 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Aldh3a1 蛋白结构

ALDH_F3AB

ALDH_F3AB: cd07132 (4 - 446)

  • 0
  • 100
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  • 453 a.a.
蛋白主名 其他名称

aldehyde dehydrogenase, dimeric NADP-preferring

alcohol dehydrogenase family 3, subfamily A1

aldehyde dehydrogenase 3, stomach cytosolic (class 3)

aldehyde dehydrogenase 4

aldehyde dehydrogenase family 3 member A1

dioxin-inducible aldehyde dehydrogenase 3

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-B0364A Dyclonine hydrochloride Inhibitor 99.86% 否
Pre-clinical Phase
生物活性分子 (15)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-123962 G6PD activator AG1 Activator 99.54% 否
HY-W017186 ALDH1A3-IN-3 Inhibitor 99.12% 否
HY-144669 ALDH1A3-IN-2 Inhibitor 99.28% 否
HY-144670 ALDH3A1-IN-1 Inhibitor ≥95.0% 否
HY-146683 KS106 99.31% 否
HY-146682 KS100 99.61% 否
HY-125085 ALDH3A1-IN-3 Inhibitor 99.30% 否
HY-122577 EN40 Inhibitor 99.56% 否
HY-134917 Aldi-2 Inhibitor / 否
HY-144671 ALDH3A1-IN-2 Inhibitor / 否
HY-159111 KS124 / 否
HY-RS00571 ALDH3A1 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00572 Aldh3a1 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00573 Aldh3a1 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00575 ALDH3B1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Aldh3a1 NCBI NCBI:218
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