DCD - dermcidin Gene

中文名称：皮肤调理素

种属: Homo sapiens

同用名: PIF; AIDD; DSEP; HCAP; DCD-1

关于 DCD

功能概要

这种抗菌基因编码一种分泌蛋白，该蛋白随后被加工成具有不同生物活性的成熟肽。 C 端肽在汗液中组成型表达，具有抗菌和抗真菌活性。 N 末端肽，也称为可扩散生存逃避肽，可在严重氧化应激条件下促进神经细胞存活。 N 末端肽的糖基化形式可能与癌症患者的恶病质 (肌肉萎缩) 有关。可变剪接导致编码不同异构体的多个转录变体。[RefSeq 提供，2014 年 10 月]

This antimicrobial gene encodes a secreted protein that is subsequently processed into mature Peptides of distinct biological activities. The C-terminal peptide is constitutively expressed in sweat and has Antibacterial and Antifungal activities. The N-terminal peptide, also known as diffusible survival evasion peptide, promotes neural cell survival under conditions of severe oxidative stress. A glycosylated form of the N-terminal peptide may be associated with cachexia (muscle wasting) in Cancer patients. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2014]