Birc3 - baculoviral IAP repeat-containing 3 Gene

中文名称：含杆状病毒 IAP 重复 3

种属: Mus musculus

同用名: Api1; Api2; IAP1; IAP2; MIHB; MIHC; Birc2; HIAP2; MIAP1; MIAP2; RNF49; cIAP1; cIAP2; C-IAP2; cIAP-1; cIAP-2

关于 Birc3

功能概要

预测该基因编码的蛋白可使半胱氨酸型内肽酶抑制剂活性参与细胞凋亡过程和泛素蛋白连接酶活性。参与多个过程，包括坏死过程；坏死过程的负调控；活性氧代谢过程的负调控。在肿瘤坏死因子的细胞反应上游或细胞反应内起作用；蛋白质多聚泛素化的正调控；和 NIK/NF-kappaB 信号的调节。预测位于胞质溶胶中；膜筏；和核质。预计是含蛋白质复合物的一部分。预计在细胞质和细胞核中有活性。在泌尿生殖系统中表达。与人类 BIRC3 同源（杆状病毒 IAP 重复包含 3）。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable cysteine-type endopeptidase inhibitor activity involved in apoptotic process and ubiquitin protein Ligase activity. Involved in several processes, including necroptotic process; negative regulation of necroptotic process; and negative regulation of Reactive Oxygen Species metabolic process. Acts upstream of or within cellular response to tumor necrosis factor; positive regulation of protein polyubiquitination; and regulation of NIK/NF-kappaB signaling. Predicted to be located in cytosol; membrane raft; and nucleoplasm. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and nucleus. Is expressed in genitourinary system. Orthologous to human BIRC3 (baculoviral IAP repeat containing 3). [provided by Alliance of Genome Resources, Apr 2022]