CLIC1 - chloride intracellular channel 1 Gene

中文名称：氯离子胞内通道 1

种属: Homo sapiens

同用名: G6; CL1C1; NCC27; CLCNL1

基因 ID: 1192 | 基因类型: protein coding

关于 CLIC1

Cytogenetic location: 6p21.33 Genomic coordinates (GRCh38): 6:31,730,581-31,737,318 (from NCBI)

This gene has 5 transcripts (splice variants), 1 gene allele, 249 orthologues and 14 paralogues. Ubiquitous expression in placenta (RPKM 110.8), bone marrow (RPKM 106.5) and 25 other tissues.

功能概要

氯离子通道是一组不同的蛋白质，可调节基本细胞过程，包括稳定细胞膜电位、跨上皮转运、维持细胞内 pH 值和调节细胞体积。氯离子细胞内通道 1 是 p64 家族的成员；该蛋白质主要定位于细胞核并表现出核和质膜氯离子通道活性。[RefSeq 提供，2008 年 7 月]

Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 1 is a member of the p64 family; the protein localizes principally to the cell nucleus and exhibits both nuclear and plasma membrane chloride ion channel activity. [provided by RefSeq, Jul 2008]

CLIC1 基因产物(3)

mRNA	Protein	Name
NM_001287593.1	NP_001274522.1	chloride intracellular channel protein 1
NM_001287594.3	NP_001274523.1	chloride intracellular channel protein 1
NM_001288.6	NP_001279.2	chloride intracellular channel protein 1

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables chloride channel activity	IDA IDA: 通过直接分析推断	9139710	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	12163479	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
acts upstream of or within chloride transport	IDA IDA: 通过直接分析推断	9139710	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in cytoplasm	IDA IDA: 通过直接分析推断	10793131	GOA
located in extracellular exosome	IDA IDA: 通过直接分析推断	15326289	GOA
located in nuclear envelope	IDA IDA: 通过直接分析推断	9139710	GOA
located in perinuclear region of cytoplasm	IDA IDA: 通过直接分析推断	12681486	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CLIC1 蛋白结构

GST_N_3

GST_C_2

0
100
200
241 a.a.

蛋白主名

其他名称

chloride intracellular channel protein 1

RNCC protein

CLIC1 蛋白互作信息

分类	蛋白名称	蛋白编号	互作蛋白	互作蛋白种属	互作蛋白编号	实验方法	参考文献
种属内	CLIC1	O00299	TPRN	Homo sapiens	Q4KMQ1-2	Anti Tag CoIP	28514442
种属内	CLIC1	O00299	TPRN	Homo sapiens	Q4KMQ1-2	Validated Y2H	32296183
种属内	CLIC1	O00299	TPRN	Homo sapiens	Q4KMQ1-2	Y2H Array	32296183
种属内	CLIC1	O00299	TPRN	Homo sapiens	Q4KMQ1-2	Y2H Prey Pooling	32296183
种属内	CLIC1	O00299	MEOX2	Homo sapiens	Q6FHY5	Validated Y2H	32296183
种属内	CLIC1	O00299	MEOX2	Homo sapiens	Q6FHY5	Y2H Array	32296183
种属内	CLIC1	O00299	MEOX2	Homo sapiens	Q6FHY5	Y2H Prey Pooling	32296183
种属内	CLIC1	O00299	NHSL2	Homo sapiens	Q5HYW2	Validated Y2H	32296183
种属内	CLIC1	O00299	LSM1	Homo sapiens	O15116	Validated Y2H	32296183
种属内	CLIC1	O00299	LSM1	Homo sapiens	O15116	Y2H Array	32296183
种属内	CLIC1	O00299	LSM1	Homo sapiens	O15116	Y2H	14667819
种属内	CLIC1	O00299	LSM1	Homo sapiens	O15116	Y2H Prey Pooling	32296183
种属内	CLIC1	O00299	PSMD10	Homo sapiens	O75832	Anti Tag CoIP	24338975
种属内	CLIC1	O00299	PSMD10	Homo sapiens	O75832	Pull Down	24338975

种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 CLIC1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P7840A	CLIC1 Protein, Human (N-His)	O00299 (A2-K241)	≥95%

CLIC1 抗体

目录号	产品名	应用	反应物种
HY-P83062	CLIC1 Antibody (YA2807)	WB, ICC/IF, IP	Human, Mouse, Rat, Hamster

关联疾病

疾病名称

别名

Intrahepatic Gall Duct Cancer

Malignant Neoplasm Of Intrahepatic Bile Ducts	Malignant Neoplasm Of Intrahepatic Gall Duct
Ca Intrahepatic Bile Ducts	Malignant Neoplasm Of Intrahepatic Biliary Passages
Intrahepatic Bile Duct Carcinoma

Colorectal Cancer

Colon Cancer	Colorectal Carcinoma
Colon Carcinoma	Colorectal Cancer, Susceptibility To
Carcinoma Of Colon	CRC
Colorectal Cancer With Chromosomal Instability, Somatic	Colon Cancer, Somatic
Colon Cancer, Susceptibility To	Colonic Neoplasms
Colorectal Neoplasms	Colorectal Cancer, Somatic
Colon Cancer, Advanced, Somatic	Colonic Carcinoma
Colorectal Carcinomas	Colon Cancers
Colorectal Cancers	Cancer, Colorectal, Somatic
Cancer, Colon	Cancer, Colorectal, Susceptibility To
Colorectal Neoplasm	Colonic Neoplasm
Malignant Tumor Of Colon

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-12693A	(Rac)-Methylindazone		/	否
HY-RS02803	CLIC1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Mus musculus	CLIC1	MGD	MGI:2148924
Rattus norvegicus	CLIC1	RGD	RGD:1303043
Bos taurus	CLIC1	VGNC	VGNC:27439
Felis catus	CLIC1	VGNC	VGNC:60959
Others	CLIC1	NCBI

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。	站点地图隐私声明
沪ICP备15051369号-4 上海工商沪公网安备31011502019417 沪(浦)应急管危经许[2021]201709(QFYS) 营业执照（三证合一）
Copyright © 2013-2025 MedChemExpress. All Rights Reserved.

MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CLIC1 - chloride intracellular channel 1 Gene

关于 CLIC1

功能概要

CLIC1 基因产物(3)

CLIC1 蛋白结构

CLIC1 蛋白互作信息

重组 CLIC1 蛋白

CLIC1 抗体

关联疾病

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

姓名
邮箱 *

Sorry, but the email address you supplied was invalid.

CLIC1 - chloride intracellular channel 1 Gene

关于 CLIC1

功能概要

CLIC1 基因产物(3)

CLIC1 蛋白结构

CLIC1 蛋白互作信息

重组 CLIC1 蛋白

CLIC1 抗体

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z