1. Gene
  2. Bgn - biglycan Gene

Bgn - biglycan Gene

种属: Mus musculus

同用名: BG; PGI; DSPG1; PG-S1; SLRR1A

基因 ID: 12111 | 基因类型: protein coding

关于 Bgn

功能概要

This gene encodes a small, leucine-rich repeat proteoglycan that plays important roles in bone mineralization and connective tissue metabolism. The encoded preproprotein undergoes post-translational processing during which chondroitin sulfate or dermatan sulfate chains are attached before incorporation into the extracellular matrix. Mice lacking the encoded protein exhibit reduced growth rate and acquire diminished bone mass progressively with age. [provided by RefSeq, Oct 2015]

Bgn 基因产物(2)

mRNA Protein Name
NM_001411776.1 NP_001398705.1 biglycan isoform 1 precursor
NM_007542.5 NP_031568.2 biglycan isoform 2 preproprotein
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cytokine binding IPI
IPI: 通过物理相互作用推断
15572151 MGI
enables extracellular matrix binding IDA
IDA: 通过直接分析推断
18757743 MGI
enables glycosaminoglycan binding IDA
IDA: 通过直接分析推断
18757743 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within articular cartilage development IGI
IGI: 通过遗传相互作用推断
19932218 MGI
acts upstream of or within bone development IGI
IGI: 通过遗传相互作用推断
19932218 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular matrix IDA
IDA: 通过直接分析推断
16810681 MGI
located in intracellular anatomical structure IDA
IDA: 通过直接分析推断
16810681 MGI
located in sarcolemma IDA
IDA: 通过直接分析推断
16810681 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

biglycan

bone/cartilage proteoglycan I

重组 Bgn 蛋白

目录号 产品名 蛋白编号 纯度
HY-P75477 Biglycan Protein, Mouse (HEK293, Fc) P28653 (D38-K369) ≥95%

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bgn NCBI NCBI:633