2. Gene
  3. Bmpr2 - bone morphogenetic protein receptor, type II (serine/threonine kinase) Gene

Bmpr2 - bone morphogenetic protein receptor, type II (serine/threonine kinase) Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：骨形态发生蛋白受体， II 型 ( 丝氨酸/苏氨酸激酶)

种属: Mus musculus

同用名: BMP-2; BRK-3; BMPR-2; BMPRII; BMPR-II; Gm20272; 2610024H22Rik

基因 ID: 12168 | 基因类型: protein coding

关于 Bmpr2

Chromosome 1: 59,802,559-59,918,173 forward strand.GRCm39:CM000994.3

This gene has 3 transcripts (splice variants), 265 orthologues, 11 paralogues and is associated with 44 phenotypes. Broad expression in lung adult (RPKM 22.1), frontal lobe adult (RPKM 8.3) and 19 other tissues.

功能概要

该基因编码一种丝氨酸/苏氨酸激酶，作为骨形态发生蛋白 (BMP) 的受体发挥作用。编码的蛋白质是一种 II 型受体，它结合细胞外 BMP，并在细胞膜上形成两种 II 型和两种 I 型受体的复合物。该复合物向下游发出信号以激活 SMAD 转录调节因子。这种信号在胚胎发育过程中很重要。该基因的突变可导致肺动脉高压。 [RefSeq 提供，2013 年 3 月]

This gene encodes a serine/threonine kinase that functions as a receptor for bone morphogenetic proteins (BMPs). The encoded protein is a type II receptor that binds extracellular BMPs and forms a complex of two type II and two type I receptors at the cell membrane. This complex signals downstream to activate SMAD transcriptional regulators. This signaling is important during embryonic development. Mutations in this gene can cause pulmonary hypertension. [provided by RefSeq, Mar 2013]

Bmpr2 基因产物(1)

mRNA Protein Name
NM_007561.4 NP_031587.1 bone morphogenetic protein receptor type-2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables BMP binding IDA
IDA: 通过直接分析推断
21976273 MGI
enables BMP receptor activity IDA
IDA: 通过直接分析推断
21976273 MGI
enables BMP receptor activity IMP
IMP: 通过突变表型推断
26774823 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
16923969 MGI
enables protein serine/threonine kinase activity IDA
IDA: 通过直接分析推断
21976273 MGI
enables protein serine/threonine kinase activity IMP
IMP: 通过突变表型推断
11714695 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in BMP signaling pathway IDA
IDA: 通过直接分析推断
21976273 MGI
acts upstream of or within BMP signaling pathway IMP
IMP: 通过突变表型推断
17472960 MGI
involved in BMP signaling pathway IMP
IMP: 通过突变表型推断
18552156 MGI
acts upstream of or within anterior/posterior pattern specification IGI
IGI: 通过遗传相互作用推断
15542835 MGI
acts upstream of or within anterior/posterior pattern specification IMP
IMP: 通过突变表型推断
10772805 MGI
involved in aortic valve development IMP
IMP: 通过突变表型推断
12441304 MGI
involved in artery development IMP
IMP: 通过突变表型推断
19903896 MGI
involved in atrial septum morphogenesis IMP
IMP: 通过突变表型推断
19409885 MGI
NOT involved in atrioventricular valve morphogenesis IMP
IMP: 通过突变表型推断
12441304 MGI
involved in blood vessel remodeling IMP
IMP: 通过突变表型推断
19903896 MGI
NOT involved in cardiac muscle tissue development IMP
IMP: 通过突变表型推断
19409885 MGI
involved in endocardial cushion development IMP
IMP: 通过突变表型推断
12441304 MGI
acts upstream of or within limb development IGI
IGI: 通过遗传相互作用推断
23610558 MGI
involved in lung alveolus development IMP
IMP: 通过突变表型推断
18552156 MGI
involved in lymphangiogenesis IMP
IMP: 通过突变表型推断
19903896 MGI
involved in lymphatic endothelial cell differentiation IMP
IMP: 通过突变表型推断
19903896 MGI
acts upstream of or within maternal placenta development IMP
IMP: 通过突变表型推断
23676498 MGI
acts upstream of or within mesoderm formation IMP
IMP: 通过突变表型推断
10772805 MGI
involved in mitral valve morphogenesis IMP
IMP: 通过突变表型推断
19409885 MGI
involved in negative regulation of cell proliferation involved in heart valve morphogenesis IMP
IMP: 通过突变表型推断
19409885 MGI
involved in negative regulation of muscle cell differentiation IDA
IDA: 通过直接分析推断
21976273 MGI
involved in negative regulation of vasoconstriction IMP
IMP: 通过突变表型推断
18552156 MGI
involved in osteoblast differentiation IDA
IDA: 通过直接分析推断
7798324 MGI
involved in outflow tract morphogenesis IMP
IMP: 通过突变表型推断
19409885 MGI
NOT involved in outflow tract septum morphogenesis IMP
IMP: 通过突变表型推断
19409885 MGI
involved in outflow tract septum morphogenesis IMP
IMP: 通过突变表型推断
12441304 MGI
NOT involved in pharyngeal arch artery morphogenesis IMP
IMP: 通过突变表型推断
19409885 MGI
involved in pharyngeal arch artery morphogenesis IMP
IMP: 通过突变表型推断
12441304 MGI
involved in positive regulation of axon extension involved in axon guidance IMP
IMP: 通过突变表型推断
24052814 MGI
involved in positive regulation of ossification IMP
IMP: 通过突变表型推断
12441304 MGI
involved in positive regulation of transcription by RNA polymerase II IMP
IMP: 通过突变表型推断
12441304 MGI
involved in pulmonary valve development IMP
IMP: 通过突变表型推断
12441304 MGI
involved in regulation of lung blood pressure IMP
IMP: 通过突变表型推断
18552156 MGI
involved in retina vasculature development in camera-type eye IMP
IMP: 通过突变表型推断
19903896 MGI
involved in semi-lunar valve development IMP
IMP: 通过突变表型推断
12441304 MGI
involved in tricuspid valve morphogenesis IMP
IMP: 通过突变表型推断
19409885 MGI
involved in venous blood vessel development IMP
IMP: 通过突变表型推断
19903896 MGI
involved in ventricular septum morphogenesis IMP
IMP: 通过突变表型推断
12441304 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in axon IDA
IDA: 通过直接分析推断
17634368 MGI
is active in cell body IDA
IDA: 通过直接分析推断
17634368 MGI
located in cell surface IDA
IDA: 通过直接分析推断
12117821 MGI
is active in clathrin-coated pit IDA
IDA: 通过直接分析推断
16923969 MGI
is active in dendrite IDA
IDA: 通过直接分析推断
17634368 MGI
is active in plasma membrane IDA
IDA: 通过直接分析推断
21976273 MGI
located in plasma membrane IDA
IDA: 通过直接分析推断
23676498 MGI
is active in plasma membrane region IDA
IDA: 通过直接分析推断
16923969 MGI
located in postsynaptic density IDA
IDA: 通过直接分析推断
17114649 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Bmpr2 蛋白结构

Activin_recp

Activin_recp: pfam01064 (45 - 126)

STKc_BMPR2_AMHR2

STKc_BMPR2_AMHR2: cd14054 (206 - 503)

  • 0
  • 200
  • 400
  • 600
  • 800
  • 1038 a.a.
蛋白主名 其他名称

bone morphogenetic protein receptor type-2

BMP type II receptor

BMP type-2 receptor

bone morphogenic protein receptor, type II (serine/threonine kinase)

相关产品

Pre-clinical Phase
生物活性分子 (10)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15897 LDN-212854 Inhibitor 99.70% 否
HY-154970A BMPR2-IN-1 TFA Inhibitor 99.40% 否
HY-154970 BMPR2-IN-1 Inhibitor / 否
HY-164145 CDD-1653 98.46% 否
HY-171249 CDD-1431 Inhibitor / 否
HY-RS01552 BMPR2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01553 Bmpr2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01554 Bmpr2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否
HY-171247 CDD-1281 Inhibitor / 否
HY-171248 CDD-1115 Inhibitor / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bmpr2 NCBI NCBI:659
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