SLC24A4 - solute carrier family 24 member 4 Gene

中文名称：溶质载体家族 24 成员 4

种属: Homo sapiens

同用名: AI2A5; NCKX4; SHEP6; SLC24A2

基因 ID: 123041 | 基因类型: protein coding

关于 SLC24A4

Cytogenetic location: 14q32.12 Genomic coordinates (GRCh38): 14:92,322,581-92,501,481 (from NCBI)

This gene has 9 transcripts (splice variants), 228 orthologues, 4 paralogues and is associated with 5 phenotypes. Low expression observed in reference dataset.

功能概要

该基因编码钾依赖性钠/钙交换蛋白家族的成员。可变剪接导致多个转录变体。[RefSeq 提供，2010 年 7 月]

This gene encodes a member of the potassium-dependent sodium/calcium exchanger protein family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

SLC24A4 基因产物(4)

mRNA	Protein	Name
NM_001378620.1	NP_001365549.1	sodium/potassium/calcium exchanger 4 isoform 1 precursor
NM_153646.4	NP_705932.2	sodium/potassium/calcium exchanger 4 isoform 1 precursor
NM_153647.4	NP_705933.2	sodium/potassium/calcium exchanger 4 isoform 2
NM_153648.4	NP_705934.1	sodium/potassium/calcium exchanger 4 isoform 3

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables calcium, potassium:sodium antiporter activity	IDA IDA: 通过直接分析推断	26631410	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in calcium ion transmembrane transport	IDA IDA: 通过直接分析推断	26631410	GOA
acts upstream of or within intracellular calcium ion homeostasis	IDA IDA: 通过直接分析推断	26631410	GOA
involved in potassium ion transmembrane transport	IDA IDA: 通过直接分析推断	26631410	GOA
involved in sodium ion transmembrane transport	IDA IDA: 通过直接分析推断	26631410	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in plasma membrane	IDA IDA: 通过直接分析推断	26631410	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SLC24A4 蛋白结构

Na_Ca_ex

0
100
200
300
400
500
622 a.a.

蛋白主名

其他名称

sodium/potassium/calcium exchanger 4

Na(+)/K(+)/Ca(2+)-exchange protein 4

关联疾病

疾病名称

别名

Amelogenesis Imperfecta, Hypomaturation Type, Iia5

Amelogenesis Imperfecta Hypomaturation Type 2a5	AI2A5
Amelogenesis Imperfecta, Type Iia5	Amelogenesis Imperfecta Hypomaturation Type Iia5
Amelogenesis Imperfecta Type Iia5	Amelogenesis Imperfecta, Hypomaturation Type, 2a5

Skin/Hair/Eye Pigmentation, Variation In, 6

Skin/Hair/Eye Pigmentation 6, Blond/Brown Hair	SHEP6
Pigmentation, Skin/Hair/Eye, Variation In, Type 6

Amelogenesis Imperfecta

Ai	Congenital Enamel Hypoplasia
Al - [Amelogenesis Imperfecta]

Amelogenesis Imperfecta, Type Iiia

Ai3	Adhcai
Amelogenesis Imperfecta Type 3	AI3A
Amelogenesis Imperfecta, Type Iii	Amelogenesis Imperfecta, Hypocalcification Type, Autosomal Dominant
Amelogenesis Imperfecta Type 3a	Amelogenesis Imperfecta Hypomineralization Type
Amelogenesis Imperfecta Type Iii	Hypocalcified Amelogenesis Imperfecta
Amelogenesis Imperfecta, Type 3	Amelogenesis Imperfecta, Hypomineralization Type
Autosomal Dominant Amelogenesis Imperfecta Hypocalcification Type	Amelogenesis Imperfecta 3a
Amelogenesis Imperfecta Hypocalcification Type Autosomal Dominant

Amelogenesis Imperfecta Hypomaturation Type

Aih	Hypomaturation Amelogenesis Imperfecta
Amelogenesis Imperfecta Type 2

Oculocutaneous Albinism

Albinism, Oculocutaneous	Oca
Albinism Oculocutaneous	Oca - [Oculocutaneous Albinism]

Albinism, Oculocutaneous, Type Ii

OCA2	Oculocutaneous Albinism Type 2
Oculocutaneous Albinism Type Ii	Albinoidism
Tyrosinase-Positive Oculocutaneous Albinism	Brown Oculocutaneous Albinism
Oculocutaneous Albinism, Tyrosinase-Positive	Albinism Ii
Albinism, Brown Oculocutaneous	Oculocutaneous Albinism, Type Ii, Modifier Of
Oculocutaneous Albinism, Type Ii	Albinism, Oculocutaneous, Type Ii, Modifier Of
Albinism 2	Albinism, Oculocutaneous, Type 2
Oculocutaneous Albinism Tyrosinase Positive	Oculocutaneous Albinism, Tyrosinase Positive
Albinism, Oculocutaneous, 2	Boca
Oca-2	Oculocutaneous Albinism Tyrosinase-Positive

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS13087	SLC24A4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	SLC24A4	RGD	RGD:1305926
Felis catus	SLC24A4	VGNC	VGNC:65251
Macaca mulatta	SLC24A4	VGNC	VGNC:77427
Mus musculus	SLC24A4	MGD	MGI:2447362
Bos taurus	SLC24A4	VGNC	VGNC:34739
Canis familiaris	SLC24A4	VGNC	VGNC:46288

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

SLC24A4 - solute carrier family 24 member 4 Gene

关于 SLC24A4

功能概要

SLC24A4 基因产物(4)

SLC24A4 蛋白结构

关联疾病

直系同源

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SLC24A4 - solute carrier family 24 member 4 Gene

关于 SLC24A4

功能概要

SLC24A4 基因产物(4)

SLC24A4 蛋白结构

关联疾病

相关产品

直系同源

热门区域

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B

C

F

G

H

J

L

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Q

S

T

X

Y

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