2. Gene
  3. Calr - calreticulin Gene

Calr - calreticulin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: CRT; Calregulin

基因 ID: 12317 | 基因类型: protein coding

关于 Calr

功能概要

Enables calcium ion binding activity; carbohydrate binding activity; and mRNA binding activity. Involved in several processes, including cellular senescence; peptide antigen assembly with MHC class I protein complex; and protein stabilization. Acts upstream of or within cortical actin Cytoskeleton organization; positive regulation of NIK/NF-kappaB signaling; and regulation of meiotic nuclear division. Located in endoplasmic reticulum; external side of plasma membrane; and extracellular space. Part of MHC class I peptide loading complex. Is expressed in several structures, including central nervous system; extraembryonic component; gut; placenta; and spleen. Used to study congestive heart failure. Human ortholog(s) of this gene implicated in essential thrombocythemia; myelofibrosis; pancreatic ductal adenocarcinoma; sideroblastic anemia; and thrombocytosis. Orthologous to human CALR (calreticulin). [provided by Alliance of Genome Resources, Apr 2022]

Calr 基因产物(1)

mRNA Protein Name
NM_007591.3 NP_031617.1 calreticulin precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables calcium ion binding IDA
IDA: 通过直接分析推断
3513762 MGI
enables carbohydrate binding IDA
IDA: 通过直接分析推断
20880849 MGI
enables mRNA binding IDA
IDA: 通过直接分析推断
14726956 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
17934213 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in cellular senescence IMP
IMP: 通过突变表型推断
14726956 MGI
acts upstream of or within cortical actin cytoskeleton organization IDA
IDA: 通过直接分析推断
15136153 MGI
involved in peptide antigen assembly with MHC class I protein complex IMP
IMP: 通过突变表型推断
11825569 MGI
involved in positive regulation of cell cycle IMP
IMP: 通过突变表型推断
14726956 MGI
involved in positive regulation of gene expression IMP
IMP: 通过突变表型推断
15998798 MGI
acts upstream of or within positive regulation of non-canonical NF-kappaB signal transduction IMP
IMP: 通过突变表型推断
24998604 MGI
involved in positive regulation of phagocytosis IMP
IMP: 通过突变表型推断
17187072 MGI
involved in protein localization to nucleus IMP
IMP: 通过突变表型推断
15998798 MGI
involved in protein stabilization IDA
IDA: 通过直接分析推断
21652723 MGI
acts upstream of or within regulation of meiotic nuclear division IDA
IDA: 通过直接分析推断
15136153 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
part of MHC class I peptide loading complex IMP
IMP: 通过突变表型推断
11825569 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
12676993 MGI
located in endoplasmic reticulum lumen IDA
IDA: 通过直接分析推断
21187406 MGI
located in endoplasmic reticulum quality control compartment IDA
IDA: 通过直接分析推断
11408579 MGI
located in external side of plasma membrane IDA
IDA: 通过直接分析推断
15136153 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
15136153 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

calreticulin

CRP55

ERp60

HACBP

endoplasmic reticulum resident protein 60

重组 Calr 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71721 Calreticulin/CALR Protein, Mouse (P.pastoris, His) P14211 (D18-L416) ≥95%
HY-P72112 Calreticulin/CALR Protein, Mouse (GST) P14211 (D18-L416) ≥95%
HY-P71721Y Calreticulin/CALR Protein, Mouse (P.pastoris, His, solution) P14211 (18D-416L) ≥95%

相关产品

Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS01847 CALR Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01848 CALR3 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Calr NCBI NCBI:811
Susscrofa domestica Calr NCBI
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