Casp3 - caspase 3 Gene

中文名称：半胱天冬酶 3

种属: Mus musculus

同用名: CC3; AC-3; Lice; Yama; mldy; CPP32; SCA-1; CASP-3; CPP-32; Caspase-3; A830040C14Rik

关于 Casp3

功能概要

该基因编码的蛋白质属于高度保守的半胱氨酰天冬氨酸特异性蛋白酶家族，可作为通过细胞凋亡进行的程序性细胞死亡的重要调节因子。该家族的成员包含一个 N 末端前域，需要在特定的天冬氨酸残基处进行切割才能成熟。由该基因编码的蛋白质属于半胱氨酰天冬氨酸特异性蛋白酶的一个亚组，这些蛋白酶被启动子半胱天冬酶激活并执行凋亡靶蛋白的蛋白水解切割。该基因缺陷的小鼠表现出多种表型，包括导致增生的神经元凋亡减少、听力丧失、骨髓基质干细胞的成骨分化减弱以及出生前和出生后的致死率。可变剪接导致多个转录本变体。 [RefSeq 提供，2015 年 9 月]

This gene encodes a protein that belongs to a highly conserved family of cysteinyl aspartate-specific proteases that function as essential regulators of programmed cell death through Apoptosis. Members of this family contain an N-terminal pro-domain and require cleavage at specific aspartate residues to become mature. The protein encoded by this gene belongs to a subgroup of cysteinyl aspartate-specific proteases that are activated by initiator caspases and that perform the proteolytic cleavage of apoptotic target proteins. Mice defective for this gene exhibit a variety of phenotypes including reduced neuronal Apoptosis resulting in hyperplasias, hearing loss, attenuated osteogenic differentiation of bone marrow stromal stem cells, and pre- and post-natal lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]