1. Gene
  2. Casp7 - caspase 7 Gene

Casp7 - caspase 7 Gene

中文名称:半胱天冬酶 7

种属: Mus musculus

同用名: Mch3; CMH-1; mCASP-7; ICE-IAP3; caspase-7

基因 ID: 12369 | 基因类型: protein coding

关于 Casp7

Chromosome 19: 56,385,561-56,430,776 forward strand.GRCm39:CM001012.3

This gene has 6 transcripts (splice variants), 218 orthologues, 11 paralogues and is associated with 1 phenotype.

功能概要

使天冬氨酸型内肽酶活性和半胱氨酸型内肽酶活性参与细胞凋亡过程。作用于多个过程的上游或内部,包括细胞凋亡的执行阶段;神经元凋亡过程;和对紫外线的反应。预测位于胞质溶胶和细胞核中。预计在细胞质中有活性。在大脑中表达;前肠;感觉器官;和泌尿系统。该基因的人类直系同源物与阿尔茨海默病有关;乳腺癌;结肠癌;和肺非小细胞癌。与人 CASP7(caspase 7)同源。 [由基因组资源联盟提供,2022 年 4 月]

Enables aspartic-type endopeptidase activity and cysteine-type endopeptidase activity involved in apoptotic process. Acts upstream of or within several processes, including execution phase of apoptosis; neuron apoptotic process; and response to UV. Predicted to be located in cytosol and nucleus. Predicted to be active in cytoplasm. Is expressed in brain; foregut; sensory organ; and urinary system. Human ortholog(s) of this gene implicated in Alzheimer's disease; breast cancer; colon cancer; and lung non-small cell carcinoma. Orthologous to human CASP7 (Caspase 7). [provided by Alliance of Genome Resources, Apr 2022]

Casp7 基因产物(1)

mRNA Protein Name
NM_007611.3 NP_031637.1 caspase-7 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables aspartic-type endopeptidase activity IDA
IDA: 通过直接分析推断
15231831 MGI
enables cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
19759058 MGI
enables cysteine-type endopeptidase activity involved in apoptotic process IDA
IDA: 通过直接分析推断
16183742 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
19759058 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of defense response to bacterium IDA
IDA: 通过直接分析推断
35705808 MGI
acts upstream of or within execution phase of apoptosis IGI
IGI: 通过遗传相互作用推断
16469926 MGI
acts upstream of or within fibroblast apoptotic process IGI
IGI: 通过遗传相互作用推断
16469926 MGI
acts upstream of or within heart development IGI
IGI: 通过遗传相互作用推断
16469926 MGI
involved in lymphocyte apoptotic process IMP
IMP: 通过突变表型推断
19168786 MGI
acts upstream of or within neuron apoptotic process IDA
IDA: 通过直接分析推断
15231831 MGI
acts upstream of positive regulation of plasma membrane repair IDA
IDA: 通过直接分析推断
35705808 MGI
involved in protein maturation IDA
IDA: 通过直接分析推断
35705808 MGI
acts upstream of or within protein processing IDA
IDA: 通过直接分析推断
15231831 MGI
acts upstream of or within response to UV IGI
IGI: 通过遗传相互作用推断
16469926 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in extracellular space IDA
IDA: 通过直接分析推断
35705808 MGI
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断
蛋白主名 其他名称

caspase-7

CASP-7

apoptotic protease Mch-3

cysteine protease LICE2

Casp7 抗体

目录号 产品名 应用 反应物种
HY-P80589 Caspase 7 Antibody WB, ICC/IF, IP Mouse, Rat

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Casp7 NCBI NCBI:840