Casp9 - caspase 9 Gene

中文名称：半胱天冬酶 9

种属: Mus musculus

同用名: Mch6; APAF-3; CASP-9; ICE-LAP6; Caspase-9

关于 Casp9

功能概要

该基因是半胱天冬酶家族的一部分，天冬氨酸特异性半胱氨酸蛋白酶因其参与免疫和细胞凋亡信号而得到充分研究。这种蛋白质，即起始半胱天冬酶，在细胞色素 c 从线粒体释放后被激活并靶向下游效应器。在小鼠中，该基因的缺陷会导致围产期致死率。这种蛋白质可能在正常的大脑发育中起作用。可变剪接导致编码不同蛋白质亚型的多个转录变体。 [RefSeq 提供，2013 年 4 月]

This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and Apoptosis signaling. This protein, the initiator Caspase, is activated after cytochrome c release from mitochondria and targets downstream effectors. In mouse, deficiency of this gene can cause perinatal lethality. This protein may have a role in normal brain development. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]