2. Gene
  3. Casp9 - caspase 9 Gene

Casp9 - caspase 9 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：半胱天冬酶 9

种属: Mus musculus

同用名: Mch6; APAF-3; CASP-9; ICE-LAP6; Caspase-9

基因 ID: 12371 | 基因类型: protein coding

关于 Casp9

Chromosome 4: 141,520,923-141,543,287 forward strand.GRCm39:CM000997.3

This gene has 6 transcripts (splice variants), 204 orthologues, 11 paralogues and is associated with 38 phenotypes. Ubiquitous expression in small intestine adult (RPKM 37.5), spleen adult (RPKM 32.3) and 28 other tissues.

功能概要

该基因是半胱天冬酶家族的一部分，天冬氨酸特异性半胱氨酸蛋白酶因其参与免疫和细胞凋亡信号而得到充分研究。这种蛋白质，即起始半胱天冬酶，在细胞色素 c 从线粒体释放后被激活并靶向下游效应器。在小鼠中，该基因的缺陷会导致围产期致死率。这种蛋白质可能在正常的大脑发育中起作用。可变剪接导致编码不同蛋白质亚型的多个转录变体。 [RefSeq 提供，2013 年 4 月]

This gene is part of a family of caspases, aspartate-specific cysteine proteases well studied for their involvement in immune and Apoptosis signaling. This protein, the initiator Caspase, is activated after cytochrome c release from mitochondria and targets downstream effectors. In mouse, deficiency of this gene can cause perinatal lethality. This protein may have a role in normal brain development. Alternative splicing results in multiple transcript variants that encode different protein isoforms. [provided by RefSeq, Apr 2013]

Casp9 基因产物(3)

mRNA Protein Name
NM_015733.5 NP_056548.2 caspase-9 isoform 1 precursor
NM_001355176.1 NP_001342105.1 caspase-9 isoform 3 precursor
NM_001277932.1 NP_001264861.1 caspase-9 isoform 2
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables cysteine-type endopeptidase activity IDA
IDA: 通过直接分析推断
16183742 MGI
enables peptidase activity IDA
IDA: 通过直接分析推断
14561754 MGI
enables protein binding IPI
IPI: 通过物理相互作用推断
14561754 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within DNA damage response IMP
IMP: 通过突变表型推断
11092819 MGI
acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process IMP
IMP: 通过突变表型推断
15776018 MGI
acts upstream of or within apoptotic process IMP
IMP: 通过突变表型推断
16469926 MGI
involved in cellular response to dexamethasone stimulus IDA
IDA: 通过直接分析推断
15944155 MGI
acts upstream of or within epithelial cell apoptotic process IDA
IDA: 通过直接分析推断
17901126 MGI
acts upstream of or within fibroblast apoptotic process IDA
IDA: 通过直接分析推断
12847083 MGI
acts upstream of neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
11150333 MGI
acts upstream of neuron apoptotic process IMP
IMP: 通过突变表型推断
11092819 MGI
acts upstream of or within positive regulation of neuron apoptotic process IGI
IGI: 通过遗传相互作用推断
11150333 MGI
acts upstream of or within positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
11092819 MGI
acts upstream of or within response to UV IMP
IMP: 通过突变表型推断
11092819 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in cytosol IDA
IDA: 通过直接分析推断
15271982 MGI
located in nucleus IDA
IDA: 通过直接分析推断
15271982 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Casp9 蛋白结构

CARD_CASP9

CARD_CASP9: cd08326 (4 - 89)

CASc

CASc: cd00032 (189 - 451)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 454 a.a.
蛋白主名 其他名称

caspase-9

ICE-like apoptotic protease 6

apoptotic protease Mch-6

apoptotic protease-activating factor 3

相关产品

Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-P5568 RP 71955 Inhibitor / 否
HY-RS01969 CASP9 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01970 Casp9 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01971 Casp9 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Casp9 NCBI NCBI:842
嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z