2. Gene
  3. GPR139 - G protein-coupled receptor 139 Gene

GPR139 - G protein-coupled receptor 139 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：G 蛋白偶联受体 139

种属: Homo sapiens

同用名: PGR3; GPRg1

基因 ID: 124274 | 基因类型: protein coding

关于 GPR139

Cytogenetic location: 16p12.3 Genomic coordinates (GRCh38): 16:20,028,239-20,073,890 (from NCBI)

This gene has 2 transcripts (splice variants), 335 orthologues and 1 paralogue. Low expression observed in reference dataset.

功能概要

该基因编码 G 蛋白偶联受体视紫红质家族的成员。编码的蛋白质几乎只在中枢神经系统中表达。 L-色氨酸和 L-苯丙氨酸可作为编码蛋白的生理配体。可变剪接导致多个转录本变体。[RefSeq 提供，2016 年 1 月]

This gene encodes a member of the rhodopsin family of G-protein-coupled receptors. The encoded protein is almost exclusively expressed in the central nervous system. L-tryptophan and L-phenylalanine may act as the physiologic ligands of the encoded protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

GPR139 基因产物(2)

mRNA Protein Name
NM_001002911.4 NP_001002911.1 probable G-protein coupled receptor 139 isoform 1
NM_001318483.1 NP_001305412.1 probable G-protein coupled receptor 139 isoform 2

GPR139 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (44 - 285)

  • 0
  • 100
  • 200
  • 300
  • 353 a.a.
蛋白主名 其他名称

probable G-protein coupled receptor 139

G protein-coupled receptor PGR3

g(q)-coupled orphan receptor GPRg1

关联疾病

疾病名称 别名
Isolated Growth Hormone Deficiency, Type Ib

Isolated Growth Hormone Deficiency Type Ib

IGHD1B

Ighd Ib

Growth Hormone Deficiency, Isolated, Type Ib

Congenital Ighd Type Ib

Congenital Isolated Gh Deficiency Type Ib

Congenital Isolated Growth Hormone Deficiency Type Ib

Dwarfism Of Sindh

Pituitary Dwarfism I

Isolated Growth Hormone Deficiency Type 1b

Ighd 1b

Growth Hormone Deficiency, Isolated, 1b
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-132228 Zelatriazin Agonist 99.89% Phase 2
Pre-clinical Phase
生物活性分子 (5)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-19838 JNJ-63533054 Agonist 99.90% 否
HY-128057 NCRW0005-F05 Antagonist ≥99.0% 否
HY-119168 LP-471756 Antagonist 99.69% 否
HY-101777 TC-O 9311 Agonist 99.70% 否
HY-149651 GPR139 agonist-2 Agonist 99.80% 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris GPR139 VGNC VGNC:41400
Macaca mulatta GPR139 VGNC VGNC:104730
Rattus norvegicus GPR139 RGD RGD:1311729
Mus musculus GPR139 MGD MGI:2685341
Felis catus GPR139 VGNC VGNC:80578
Bos taurus GPR139 VGNC VGNC:29553
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