Cd1d1 - CD1d1 antigen Gene

种属: Mus musculus

同用名: Cd1a; Cd1d; CD1.1; Ly-38

基因 ID: 12479 | 基因类型: protein coding

关于 Cd1d1

功能概要

Enables T cell receptor binding activity and endogenous lipid antigen binding activity. Involved in NK T cell differentiation and regulation of immature T cell proliferation in thymus. Acts upstream of or within several processes, including antigen processing and presentation, exogenous lipid antigen via MHC class Ib; positive regulation of cytokine production; and positive regulation of leukocyte activation. Located in endosome; external side of plasma membrane; and lysosome. Is expressed in forebrain; intestine; jaw bone; and liver. Human ortholog(s) of this gene implicated in pulmonary tuberculosis. Orthologous to human CD1d (CD1d molecule). [provided by Alliance of Genome Resources, Apr 2022]

Cd1d1 基因产物(13)

mRNA	Protein	Name
NM_001379501.1	NP_001366430.1	antigen-presenting glycoprotein CD1d1 isoform 2 precursor
NM_001379502.1	NP_001366431.1	antigen-presenting glycoprotein CD1d1 isoform 3 precursor
NM_001379503.1	NP_001366432.1	antigen-presenting glycoprotein CD1d1 isoform 4
NM_001409614.1	NP_001396543.1	antigen-presenting glycoprotein CD1d1 isoform 5 precursor
NM_001409615.1	NP_001396544.1	antigen-presenting glycoprotein CD1d1 isoform 1 precursor
NM_001409616.1	NP_001396545.1	antigen-presenting glycoprotein CD1d1 isoform 4
NM_001409617.1	NP_001396546.1	antigen-presenting glycoprotein CD1d1 isoform 4
NM_001409618.1	NP_001396547.1	antigen-presenting glycoprotein CD1d1 isoform 4
NM_001409619.1	NP_001396548.1	antigen-presenting glycoprotein CD1d1 isoform 6
NM_001409620.1	NP_001396549.1	antigen-presenting glycoprotein CD1d1 isoform 8
NM_001409621.1	NP_001396550.1	antigen-presenting glycoprotein CD1d1 isoform 9 precursor
NM_001409622.1	NP_001396551.1	antigen-presenting glycoprotein CD1d1 isoform 7 precursor
NM_007639.4	NP_031665.2	antigen-presenting glycoprotein CD1d1 isoform 1 precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables T cell receptor binding	IDA IDA: 通过直接分析推断	22065767	MGI
enables endogenous lipid antigen binding	IDA IDA: 通过直接分析推断	14722359	MGI
enables protein binding	IPI IPI: 通过物理相互作用推断	11754812	MGI

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in NK T cell differentiation	IMP IMP: 通过突变表型推断	9133426	MGI
acts upstream of or within antigen processing and presentation	IDA IDA: 通过直接分析推断	11754812	MGI
acts upstream of or within antigen processing and presentation, exogenous lipid antigen via MHC class Ib	IDA IDA: 通过直接分析推断	14557411	MGI
acts upstream of or within positive regulation of NK T cell activation	IDA IDA: 通过直接分析推断	7538697	MGI
acts upstream of or within positive regulation of NK T cell differentiation	IMP IMP: 通过突变表型推断	9133426	MGI
acts upstream of or within positive regulation of T cell mediated cytotoxicity	IDA IDA: 通过直接分析推断	10201995	MGI
acts upstream of or within positive regulation of interleukin-2 production	IDA IDA: 通过直接分析推断	7538697	MGI
acts upstream of or within positive regulation of interleukin-4 production	IDA IDA: 通过直接分析推断	7538697	MGI
acts upstream of or within positive regulation of interleukin-4 production	IMP IMP: 通过突变表型推断	9133426	MGI
acts upstream of or within positive regulation of macrophage activation	IDA IDA: 通过直接分析推断	21460847	MGI
acts upstream of or within positive regulation of type II interferon production	IMP IMP: 通过突变表型推断	9133426	MGI
acts upstream of or within positive thymic T cell selection	IMP IMP: 通过突变表型推断	9133426	MGI
involved in regulation of immature T cell proliferation in thymus	IMP IMP: 通过突变表型推断	11550008	MGI
acts upstream of or within regulation of immune response	IMP IMP: 通过突变表型推断	9133426	MGI

细胞组分 GO 注释	逻辑证据	参考文献	来源
located in early endosome	IDA IDA: 通过直接分析推断	11754812	MGI
located in external side of plasma membrane	IDA IDA: 通过直接分析推断	9133426	MGI
located in late endosome	IDA IDA: 通过直接分析推断	11754812	MGI
located in lysosome	IDA IDA: 通过直接分析推断	11754812	MGI

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

蛋白主名

其他名称

antigen-presenting glycoprotein CD1d1

T-cell surface glycoprotein CD1d1

重组 Cd1d1 蛋白

目录号	产品名	蛋白编号	纯度
HY-P75436	CD1D Protein, Mouse (HEK293, His-Fc)	P11609 (M1-G305)	≥95%
HY-P75437	CD1D Protein, Mouse (HEK293, His)	P11609 (M1-G305)	≥95%
HY-P76778	CD1D1-B2M Heterodimer Protein, Mouse (HEK293, His)	P11609 (Q22-W297)&P01887 (I21-M119)	≥95%

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