1. Gene
  2. TMIGD2 - transmembrane and immunoglobulin domain containing 2 Gene

TMIGD2 - transmembrane and immunoglobulin domain containing 2 Gene

中文名称:含跨膜和免疫球蛋白结构域 2

种属: Homo sapiens

同用名: CD28H; IGPR1; IGPR-1

基因 ID: 126259 | 基因类型: protein coding

关于 TMIGD2

Cytogenetic location: 19p13.3 Genomic coordinates (GRCh38): 19:4,292,227-4,302,389 (from NCBI)

This gene has 4 transcripts (splice variants) and 43 orthologues. Broad expression in lymph node (RPKM 1.8), spleen (RPKM 1.5) and 14 other tissues.

功能概要

启用辅助受体活动。参与 T 细胞活化的正调节;血管生成的正向调节;和细胞因子产生的正调节。预测位于质膜中。预计是膜的组成部分。预计在细胞外空间活跃。 [由基因组资源联盟提供,2022 年 4 月]

Enables coreceptor activity. Involved in positive regulation of T cell activation; positive regulation of angiogenesis; and positive regulation of cytokine production. Predicted to be located in plasma membrane. Predicted to be integral component of membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

TMIGD2 基因产物(4)

mRNA Protein Name
NM_001169126.2 NP_001162597.1 transmembrane and immunoglobulin domain-containing protein 2 isoform 2 precursor
NM_001308232.2 NP_001295161.1 transmembrane and immunoglobulin domain-containing protein 2 isoform 3
NM_001395549.1 NP_001382478.1 transmembrane and immunoglobulin domain-containing protein 2 isoform 4 precursor
NM_144615.3 NP_653216.2 transmembrane and immunoglobulin domain-containing protein 2 isoform 1 precursor
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables coreceptor activity IDA
IDA: 通过直接分析推断
23784006 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
23784006 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in T cell costimulation IDA
IDA: 通过直接分析推断
23784006 GOA
involved in positive regulation of activated T cell proliferation IDA
IDA: 通过直接分析推断
23784006 GOA
involved in positive regulation of angiogenesis IMP
IMP: 通过突变表型推断
22419821 GOA
involved in positive regulation of cytokine production IDA
IDA: 通过直接分析推断
23784006 GOA
EXP:通过实验结果推断 IDA:通过直接分析推断 IPI:通过物理相互作用推断 IMP:通过突变表型推断 IGI:通过遗传相互作用推断 IEP:通过表达模式推断

TMIGD2 蛋白结构

Ig_2

Ig_2: Immunoglobulin domain (30 - 115)

  • 0
  • 100
  • 200
  • 282 a.a.
蛋白主名 其他名称

transmembrane and immunoglobulin domain-containing protein 2

CD28 homolog

重组 TMIGD2 蛋白

目录号 产品名 蛋白编号 纯度
HY-P71370 TMIGD2 Protein, Human (HEK293, His) Q96BF3-1 (L23-G150) ≥95%
HY-P77249 TMIGD2 Protein, Human (HEK293, Fc) Q96BF3-1/NP_653216.2 (L23-G150) ≥95%