2. Academic Validation
  3. B7-H5 costimulates human T cells via CD28H

B7-H5 costimulates human T cells via CD28H

  • Nat Commun. 2013:4:2043. doi: 10.1038/ncomms3043.
Yuwen Zhu 1,  Sheng Yao,  Bettina P Iliopoulou,  Xue Han,  Mathew M Augustine,  Haiying Xu,  Ryan T Phennicie,  Sarah J Flies,  Megan Broadwater,  William Ruff,  Janis M Taube,  Linghua Zheng,  Liqun Luo,  Gefeng Zhu,  Jianzhu Chen,  Lieping Chen
Affiliations

Affiliation

  • 1 Department of Immunobiology, Yale University School of Medicine, New Haven, Connecticut 06520, USA.
PMID: 23784006 DOI: 10.1038/ncomms3043
Abstract

The B7/CD28 family has profound modulatory effects in immune responses and constitutes an important target for the development of novel therapeutic drugs against human diseases. Here we describe a new CD28 homologue (CD28H) that has unique functions in the regulation of the human immune response and is absent in mice. CD28H is constitutively expressed on all naive T cells. Repetitive antigenic exposure, however, induces a complete loss of CD28H on many T cells, and CD28H negative T cells have a phenotype of terminal differentiation and senescence. After extensive screening in a receptor array, a B7-like molecule, B7 homologue 5 (B7-H5), was identified as a specific ligand for CD28H. B7-H5 is constitutively found in macrophages and could be induced on dendritic cells. The B7-H5/CD28H interaction selectively costimulates human T-cell growth and cytokine production via an AKT-dependent signalling cascade. Our study identifies a novel costimulatory pathway regulating human T-cell responses.

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