2. Gene
  3. ADH5 - alcohol dehydrogenase 5 (class III), chi polypeptide Gene

ADH5 - alcohol dehydrogenase 5 (class III), chi polypeptide Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：乙醇脱氢酶 5 (III 类),chi 多肽

种属: Homo sapiens

同用名: FDH; ADHX; ADH-3; AMEDS; BMFS7; FALDH; GSNOR; GSH-FDH; HEL-S-60p

基因 ID: 128 | 基因类型: protein coding

关于 ADH5

Cytogenetic location: 4q23 Genomic coordinates (GRCh38): 4:99,070,978-99,088,788 (from NCBI)

This gene has 13 transcripts (splice variants), 391 orthologues, 17 paralogues and is associated with 1 phenotype. Ubiquitous expression in endometrium (RPKM 69.1), kidney (RPKM 68.7) and 25 other tissues.

功能概要

该基因编码醇脱氢酶家族的一个成员。该家族的成员代谢多种底物，包括乙醇、视黄醇、其他脂肪醇、羟基类固醇和脂质过氧化产物。编码的蛋白质形成同型二聚体。它对乙醇氧化几乎没有活性，但对长链伯醇的氧化和 S-羟甲基谷胱甘肽 (甲醛和谷胱甘肽之间的自发加合物) 的氧化表现出高活性。这种酶是消除甲醛的细胞代谢的重要组成部分，甲醛是一种引起流泪、鼻炎、咽炎和接触性皮炎的强刺激性和致敏剂。人类基因组包含几个与该基因相关的非转录假基因。[RefSeq 提供，2008 年 10 月]

This gene encodes a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, Other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The encoded protein forms a homodimer. It has virtually no activity for ethanol oxidation, but exhibits high activity for oxidation of long-chain primary alcohols and for oxidation of S-hydroxymethyl-glutathione, a spontaneous adduct between formaldehyde and glutathione. This Enzyme is an important component of cellular metabolism for the elimination of formaldehyde, a potent irritant and sensitizing agent that causes lacrymation, rhinitis, pharyngitis, and contact dermatitis. The human genome contains several non-transcribed pseudogenes related to this gene. [provided by RefSeq, Oct 2008]

ADH5 基因产物(1)

mRNA Protein Name
NM_000671.4 NP_000662.3 alcohol dehydrogenase class-3
基因本体论
  • 分子功能
  • 生物过程
分子功能 GO 注释 逻辑证据 参考文献 来源
enables fatty acid binding IDA
IDA: 通过直接分析推断
8460164 GOA
enables formaldehyde dehydrogenase (NAD+) activity IDA
IDA: 通过直接分析推断
8460164 GOA
enables zinc ion binding IDA
IDA: 通过直接分析推断
6375718 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in fatty acid omega-oxidation IDA
IDA: 通过直接分析推断
16081420 GOA
involved in response to redox state IDA
IDA: 通过直接分析推断
8460164 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADH5 蛋白结构

ADH_N

ADH_N: Alcohol dehydrogenase GroES-like domain (33 - 159)

ADH_zinc_N

ADH_zinc_N: Zinc-binding dehydrogenase (202 - 323)

  • 0
  • 100
  • 200
  • 300
  • 374 a.a.
蛋白主名 其他名称

alcohol dehydrogenase class-3

S-(hydroxymethyl)glutathione dehydrogenase

S-nitrosoglutathione reductase

alcohol dehydrogenase (class III), chi polypeptide

alcohol dehydrogenase class chi chain

alcohol dehydrogenase class-III

epididymis secretory sperm binding protein Li 60p

formaldehyde dehydrogenase

glutathione-dependent formaldehyde dehydrogenase

ADH5 抗体

目录号 产品名 应用 反应物种
HY-P82253 ADH5 Antibody (YA1998) WB, IHC-P, IP Human

关联疾病

疾病名称 别名
Contact Dermatitis

Contact Dermatitis/Eczema

Contact Eczema

Dermatitis Venenata

Dermatitis, Venenata

Dermatitis Contact

Dermatitis, Contact
Thyroid Dyshormonogenesis 3

TDH3

Hypothyroidism, Congenital, Due To Dyshormonogenesis, 3

Thyroid Hormonogenesis, Genetic Defect In, 3

Genetic Defect In Thyroid Hormonogenesis 3

Chdh3

Congenital Hypothyroidism Due To Dyshormonogenesis Type 3

Genetic Defect In Thyroid Hormonogenesis Type 3
Familial Thyroid Dyshormonogenesis

Thyroid Dyshormonogenesis

Familial Dyshormonogenetic Goiter
Proliferative Type Fibrocystic Change Of Breast

Fibrocystic Change, Proliferative Type With Atypia

Fibrocystic Disease, Proliferative Type With Atypia

Proliferating Lesion Of Breast Without Atypia

Proliferating Lesion Of The Breast Without Atypia

Proliferative Fibrocystic Change

Breast Fibrocystic Change, Proliferative Type
Breast Intraductal Proliferative Lesion

Intraductal Proliferative Lesion

Intraductal Proliferative Lesion Of The Breast
Pharyngitis

Acute Pharyngitis

Chronic Pharyngitis

Acute Sore Throat

Chronic Sore Throat

Persistent Sore Throat

Pharyngeal Diseases

Chronic Pharyn/Nasopharyngitis

Chronic Pharyngitis And Nasopharyngitis

Inflamed Throat

Pharyngeal Disease

Pharyngeal Disorder

Pharyngitis - Acute

Sore Throat - Chronic

Acute Pharyngitis Nos

Acute Sore Throat Nos

Acute Throat Inflammation

Infective Pharyngitis

Infection Of Pharynx

Acute Infective Pharyngitis

Acute Infective Pharyngitis Nos

Acute Pharyngeal Inflammation

Inflammation Of The Throat

Throat Inflammation

Throat Infection

Putrid Pharyngitis

Pharyngeal Inflammation

Pharyngitis Nos

Chronic Throat Pain

Throat Catarrh
Congenital Hypothyroidism

Cretinism

Neonatal Hypothyroidism

Ch

Cht

Congenital Myxedema

Myxedema, Congenital

Endemic Cretinism

Congenital Iodine-Deficiency Syndrome

Fetal Iodine Deficiency Syndrome

Congenital Iodine-Deficiency Hypothyroidism Nos
Substance Dependence
Amed Syndrome, Digenic

Amed Syndrome

AMEDS

Bone Marrow Failure Syndrome 7, Digenic

Bmfs7

Aplastic Anemia-Intellectual Disability-Dwarfism Syndrome
Alcohol Dependence

Alcoholism

Alcohol Dependence, Susceptibility To

Aerodigestive Tract Cancer, Squamous Cell, Alcohol-Related, Protection Against

Alcohol Dependence, Protection Against

Alcoholism, Susceptibility To

Alcoholic Intoxication, Chronic

Pharyngeal Neoplasms

Chronic Alcoholism

Dipsomania

Alcohol Addiction

Ethanol Dependence

Chronic Ethanolism

Chronic Alcoholic Disease Nos

Alcoholic Disease Nos

Alcoholic
Focal Dermal Hypoplasia

Goltz Syndrome

Goltz-Gorlin Syndrome

FDH

FODH

Dhof

Goltz Gorlin Syndrome

Hypoplasia, Dermal, Focal
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00370 ADH5 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00371 Adh5 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00372 Adh5 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus ADH5 MGD MGI:87929
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