Cnr1 - cannabinoid receptor 1 (brain) Gene

中文名称：大麻素受体 1 (大脑)

种属: Mus musculus

同用名: CB1; CB-R; CB1A; CB1B; CB1R

关于 Cnr1

功能概要

使大麻素受体活性和电压门控钙通道活性参与突触前细胞溶质钙水平的正调节。参与大麻素信号通路；内源性大麻素的逆行跨突触信号；和内源性大麻素的跨突触信号，调节突触传递。作用于轴突束颤和葡萄糖稳态的上游或内部。位于多个细胞成分中，包括 GABA 能突触；生长锥;和突触前膜。是线粒体膜的组成部分和突触前膜的组成部分。在谷氨酸能突触和突触前活跃。以多种结构表达，包括消化系统；泌尿生殖系统；外皮系统；神经系统;和感觉器官。该基因的人类直系同源物与肥胖有关；精神分裂症;和 2 型糖尿病。与人类 CNR1（大麻素受体 1）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables Cannabinoid Receptor activity and voltage-gated Calcium Channel activity involved in positive regulation of presynaptic cytosolic calcium levels. Involved in cannabinoid signaling pathway; retrograde trans-synaptic signaling by endocannabinoid; and trans-synaptic signaling by endocannabinoid, modulating synaptic transmission. Acts upstream of or within axonal fasciculation and glucose homeostasis. Located in several cellular components, including GABA-ergic synapse; growth cone; and presynaptic membrane. Is integral component of mitochondrial membrane and integral component of presynaptic membrane. Is active in glutamatergic synapse and presynapse. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in obesity; schizophrenia; and type 2 diabetes mellitus. Orthologous to human CNR1 (Cannabinoid Receptor 1). [provided by Alliance of Genome Resources, Apr 2022]