2. Gene
  3. NUP35 - nucleoporin 35 Gene

NUP35 - nucleoporin 35 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：核孔蛋白 35

种属: Homo sapiens

同用名: MP44; NP44; MP-44; NUP53

基因 ID: 129401 | 基因类型: protein coding

关于 NUP35

Cytogenetic location: 2q32.1 Genomic coordinates (GRCh38): 2:183,117,514-183,161,680 (from NCBI)

This gene has 10 transcripts (splice variants) and 215 orthologues. Ubiquitous expression in testis (RPKM 6.9), adrenal (RPKM 3.5) and 25 other tissues.

功能概要

该基因编码核孔蛋白家族的一个成员。编码的蛋白质包含两个膜结合区域，位于核边缘，是核孔复合体的一部分。所有进入或离开细胞核的分子要么扩散通过核孔复合体，要么由核孔复合体主动运输。可变剪接导致多个转录本变体。该基因的假基因已在 7 号和 10 号染色体上定义。[RefSeq 提供，2013 年 12 月]

This gene encodes a member of the nucleoporin family. The encoded protein contains two membrane binding regions, is localized to the nuclear rim, and is part of the nuclear pore complex. All molecules entering or leaving the nucleus either diffuse through or are actively transported by the nuclear pore complex. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 7 and 10. [provided by RefSeq, Dec 2013]

NUP35 基因产物(3)

mRNA Protein Name
NM_001287584.2 NP_001274513.1 nucleoporin NUP35 isoform b
NM_001287585.2 NP_001274514.1 nucleoporin NUP35 isoform c
NM_138285.5 NP_612142.2 nucleoporin NUP35 isoform a
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
25416956 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in nuclear envelope IDA
IDA: 通过直接分析推断
24315095 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

NUP35 蛋白结构

Nup35_RRM

Nup35_RRM: Nup53/35/40-type RNA recognition motif (169 - 250)

  • 0
  • 100
  • 200
  • 300
  • 326 a.a.
蛋白主名 其他名称

nucleoporin NUP35

mitotic phosphoprotein 44

NUP35 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
NUP35 Q8NFH5 KCTD9 Homo sapiens Q7L273
Validated Y2H
25416956
种属内
NUP35 Q8NFH5 KCTD9 Homo sapiens Q7L273
Anti Tag CoIP
28514442
种属内
NUP35 Q8NFH5 KCTD9 Homo sapiens Q7L273
Y2H Array
25416956
种属内
NUP35 Q8NFH5 KCTD9 Homo sapiens Q7L273
Anti Tag CoIP
33961781
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Seminal Vesicle Tumor

Tumor Of Seminal Vesicle

Seminal Vesicle Neoplasm

Seminal Vesicle Tumour

Tumour Of Seminal Vesicle
Achalasia-Addisonianism-Alacrima Syndrome

Allgrove Syndrome

Triple-A Syndrome

Achalasia-Addisonianism-Alacrimia Syndrome

Alacrima-Achalasia-Adrenal Insufficiency Neurologic Disorder

Triple A Syndrome

Aaa Syndrome

AAAS

Glucocorticoid Deficiency With Achalasia

Glucocorticoid Deficiency And Achalasia

Addisonian-Achalasia Syndrome

Hypoadrenalism With Achalasia

Alacrima-Achalasia-Addisonianism

Aaa

Acth-Resistant Adrenal Insufficiency, Achalasia And Alacrima

Achalasia Addisonianism Alacrimia Syndrome

Achalasia Alacrima Syndrome

Addisonian Achalasia Syndrome

Achalasia-Addisonian Syndrome

Achalasia-Alacrima Syndrome

2a Syndrome

3a Syndrome

4a Syndrome

Adrenal Insufficiency-Achalasia-Alacrima Syndrome

Double A Syndrome

Quaternary A Syndrome

Acth-Resistant Adrenal Insufficiency With Achalasia And Alacrima

Allgrove'S Syndrome

Adrenal Gland Hypofunction

Adrenal Cortical Hypofunction
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS09693 NUP35 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Mus musculus NUP35 MGD MGI:1916732
Bos taurus NUP35 VGNC VGNC:32359
Macaca mulatta NUP35 VGNC VGNC:75486
Canis familiaris NUP35 VGNC VGNC:44053
Felis catus NUP35 VGNC VGNC:63924
Rattus norvegicus NUP35 RGD RGD:1303069
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