Ctsc - cathepsin C Gene

中文名称：组织蛋白酶 C

种属: Mus musculus

同用名: CatC; DPP1; DPPI

关于 Ctsc

功能概要

该基因编码半胱氨酸蛋白酶肽酶 C1（木瓜蛋白酶）家族的成员。可变剪接导致多个转录本变体，其中至少一个编码前原蛋白，该前原蛋白经过蛋白水解处理以产生多种蛋白质产物。这些产物包括二肽基肽酶 1 轻链、重链和排斥域链，它们一起构成同源四聚体酶的一个亚基。这种酶具有氨基二肽酶活性，可能在炎症期间激活颗粒酶中发挥作用。该基因的纯合基因敲除小鼠在脓毒症模型中表现出受损的颗粒酶激活和增强的存活率。 [RefSeq 提供，2015 年 8 月]

This gene encodes a member of the peptidase C1 (papain) family of cysteine proteases. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the Dipeptidyl Peptidase 1 light, heavy, and exclusion domain chains, which together comprise one subunit of the homotetrameric Enzyme. This Enzyme has amino dipeptidase activity and may play a role in the activation of granzymes during inflammation. Homozygous knockout mice for this gene exhibit impaired granzyme activation and enhanced survival in a sepsis model. [provided by RefSeq, Aug 2015]