2. Gene
  3. CPA1 - carboxypeptidase A1 Gene

CPA1 - carboxypeptidase A1 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：羧肽酶 A1

种属: Homo sapiens

同用名: CPA

基因 ID: 1357 | 基因类型: protein coding

关于 CPA1

Cytogenetic location: 7q32.2 Genomic coordinates (GRCh38): 7:130,380,494-130,388,108 (from NCBI)

This gene has 9 transcripts (splice variants), 264 orthologues, 8 paralogues and is associated with 1 phenotype. Restricted expression toward pancreas (RPKM 26661.6).

功能概要

该基因编码锌金属蛋白酶羧肽酶 A 家族的一个成员。这种酶在胰腺中产生，优先从膳食蛋白质中切割 C 末端支链氨基酸和芳香族氨基酸。该基因和几个家族成员存在于 7 号染色体上的一个基因簇中。该基因的突变可能与慢性胰腺炎有关，而蛋白质水平升高可能与胰腺癌有关。[RefSeq 提供，2015 年 1 月]

This gene encodes a member of the Carboxypeptidase A family of zinc metalloproteases. This Enzyme is produced in the pancreas and preferentially cleaves C-terminal branched-chain and aromatic Amino acids from dietary proteins. This gene and several family members are present in a gene cluster on chromosome 7. Mutations in this gene may be linked to chronic pancreatitis, while elevated protein levels may be associated with pancreatic Cancer. [provided by RefSeq, Jan 2015]

CPA1 基因产物(1)

mRNA Protein Name
NM_001868.4 NP_001859.1 carboxypeptidase A1 preproprotein
基因本体论
  • 分子功能
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables metallocarboxypeptidase activity IDA
IDA: 通过直接分析推断
20385563 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
19179285 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in extracellular space IDA
IDA: 通过直接分析推断
2920728 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CPA1 蛋白结构

Propep_M14

Propep_M14: Carboxypeptidase activation peptide (26 - 101)

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (128 - 405)

  • 0
  • 100
  • 200
  • 300
  • 419 a.a.
蛋白主名 其他名称

carboxypeptidase A1

carboxypeptidase A1 (pancreatic)

重组 CPA1 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7732 Carboxypeptidase A1/CPA1 Protein, Human (HEK293, His) AAH05279.1 (K17-Y419) ≥95%

关联疾病

疾病名称 别名
Pancreatitis

Mumps Pancreatitis
Pancreatitis, Hereditary

Hereditary Pancreatitis

Chronic Pancreatitis

Hereditary Chronic Pancreatitis

Hp

Pancreatitis, Chronic, Susceptibility To

PCTT

Hpc

Pancreatitis, Chronic

Pancreatitis, Chronic, Protection Against

Autosomal Dominant Hereditary Pancreatitis

Familial Pancreatitis

Cp

Pancreatitis Hereditary
Spermatogenic Failure 24

SPGF24
Pancreatic Cancer

Pancreatic Carcinoma

Carcinoma Of Pancreas

Familial Pancreatic Carcinoma

Pancreatic Neoplasm

Pancreatic Carcinoma, Familial

Malignant Neoplasm Of Pancreas

Pancreatic Acinar Carcinoma

Pancreatic Tumor

Familial Pancreatic Cancer

Neoplasm Of The Pancreas

Cancer Of The Pancreas

Pancreatic Carcinoma, Somatic

Pancreatic Cancer, Somatic

Ca Body Of Pancreas

Ca Head Of Pancreas

Ca Tail Of Pancreas

Malignant Neoplasm Of Body Of Pancreas

Malignant Neoplasm Of Head Of Pancreas

Malignant Neoplasm Of Tail Of Pancreas

Pancreas Neoplasm

Exocrine Cancer

Exocrine Pancreas Carcinoma

Hereditary Pancreatic Cancer

Hereditary Pancreatic Carcinoma

PNCA

Pancreatic Cancer, Susceptibility To

Carcinoma Of Head Of Pancreas

Pancreatic Neoplasms

Pancreatic Tumors

Cancer, Pancreatic

Cancer Of Pancreas

Mixed Islet Cell With Exocrine Carcinoma Of Unspecified Site
Pancreatic Acinar Cell Adenocarcinoma

Pancreatic Acinar Cell Carcinoma

Acinar Cell Adenocarcinoma Of The Pancreas
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-W044764 2-Benzylsuccinic acid Inhibitor 99.41% 否
HY-P10231 Ac-Phe-Thiaphe-OH / 否
HY-RS03080 CPA1 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CPA1 VGNC VGNC:39543
Bos taurus CPA1 VGNC VGNC:27642
Mus musculus CPA1 MGD MGI:88478
Macaca mulatta CPA1 VGNC VGNC:71455
Rattus norvegicus CPA1 RGD RGD:2388
Felis catus CPA1 VGNC VGNC:61111
Others CPA1 NCBI
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