2. Gene
  3. S1pr3 - sphingosine-1-phosphate receptor 3 Gene

S1pr3 - sphingosine-1-phosphate receptor 3 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：1-磷酸鞘氨醇受体 3

种属: Mus musculus

同用名: Edg3; Lpb3; S1p3

基因 ID: 13610 | 基因类型: protein coding

关于 S1pr3

Chromosome 13: 51,562,675-51,576,833 forward strand.GRCm39:CM001006.3

This gene has 1 transcript (splice variant), 194 orthologues, 18 paralogues and is associated with 19 phenotypes. Broad expression in limb E14.5 (RPKM 3.), lung adult (RPKM 2.8) and 19 other tissues.

功能概要

该基因编码 G 蛋白偶联受体 1 家族的一个成员。编码的蛋白质是溶血磷脂鞘氨醇 1-磷酸的受体。该基因产物在内皮细胞中发挥作用，并参与血管和心脏发育。该基因产物介导 HDL 和 HDL 相关溶血磷脂诱导的血管舒张，并在血管生成过程中与其他溶血磷脂受体协调。 [RefSeq 提供，2010 年 1 月]

This gene encodes a member of the G-protein coupled receptor 1 family. The encoded protein is a receptor for the lysophospholipid sphingosine 1-phosphate. The gene product functions in endothelial cells and is involved in vascular and heart development. The gene product mediates HDL and HDL-associated lysophospholipid-induced vasorelaxation, and it coordinates with other lysophospholipid receptors in the process of angiogenesis. [provided by RefSeq, Jan 2010]

S1pr3 基因产物(1)

mRNA Protein Name
NM_010101.4 NP_034231.1 sphingosine 1-phosphate receptor 3
基因本体论
  • 生物过程
  • 细胞组分
生物过程 GO 注释 逻辑证据 参考文献 来源
acts upstream of or within Notch signaling pathway IDA
IDA: 通过直接分析推断
23117660 MGI
acts upstream of or within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway IDA
IDA: 通过直接分析推断
11443127 MGI
acts upstream of or within cytokine production IMP
IMP: 通过突变表型推断
18305483 MGI
acts upstream of or within inflammatory response IMP
IMP: 通过突变表型推断
18305483 MGI
acts upstream of or within regulation of interleukin-1 beta production IMP
IMP: 通过突变表型推断
18305483 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
is active in presynapse IDA
IDA: 通过直接分析推断
35781853 MGI
is active in presynapse IEP
IEP: 通过表达模式推断
35781853 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

S1pr3 蛋白结构

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (42 - 67)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (42 - 308)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (74 - 99)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (111 - 141)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (152 - 172)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (192 - 221)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (235 - 265)

7tmA_S1PR3_Edg3

7tmA_S1PR3_Edg3: cd15345 (276 - 301)

  • 0
  • 100
  • 200
  • 300
  • 378 a.a.
蛋白主名 其他名称

sphingosine 1-phosphate receptor 3

S1P receptor Edg-3

S1p receptor 3

endothelial differentiation G-protein coupled receptor 3

endothelial differentiation sphingolipid G-protein-coupled receptor 3

lysophospholipid receptor B3

sphingosine 1-phosphate receptor Edg-3

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12355 Siponimod Agonist 99.95% 否
HY-10569 Ponesimod Agonist 99.81% 是
HY-12355A Siponimod hemifumarate Agonist / 否
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-119401 CAY10444 Antagonist ≥98.0% 否
HY-111253 CYM-5478 Agonist 99.90% 否
HY-113934 L-threo Lysosphingomyelin (d18:1) Agonist ≥98.0% 否
HY-108492 TC-SP 14 Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens S1pr3 NCBI NCBI:1903
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