2. Gene
  3. S1PR3 - sphingosine-1-phosphate receptor 3 Gene

S1PR3 - sphingosine-1-phosphate receptor 3 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：1-磷酸鞘氨醇受体 3

种属: Homo sapiens

同用名: EDG3; LPB3; S1P3; EDG-3; C9orf47; C9orf108; bA791O21.3

基因 ID: 1903 | 基因类型: protein coding

关于 S1PR3

Cytogenetic location: 9q22.1 Genomic coordinates (GRCh38): 9:88,990,863-89,005,155 (from NCBI)

This gene has 5 transcripts (splice variants), 194 orthologues and 18 paralogues. Ubiquitous expression in adrenal (RPKM 15.3), esophagus (RPKM 10.2) and 24 other tissues.

功能概要

该基因编码 EDG 受体家族成员，即 G 蛋白偶联受体。这种蛋白质已被确定为鞘氨醇 1-磷酸的功能性受体，可能有助于调节血管生成和血管内皮细胞功能。[RefSeq 提供，2008 年 7 月]

This gene encodes a member of the EDG family of receptors, which are G protein-coupled receptors. This protein has been identified as a functional receptor for sphingosine 1-phosphate and likely contributes to the regulation of angiogenesis and vascular endothelial cell function. [provided by RefSeq, Jul 2008]

S1PR3 基因产物(6)

mRNA Protein Name
NR_172883.1
NM_001142413.2
NM_001395848.1 NP_001382777.1 sphingosine 1-phosphate receptor 3
NR_172882.1
NM_005226.4 NP_005217.2 sphingosine 1-phosphate receptor 3
NM_001001938.4
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables integrin binding IPI
IPI: 通过物理相互作用推断
24851274 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
24851274 GOA
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of establishment of endothelial barrier IMP
IMP: 通过突变表型推断
24851274 GOA
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in plasma membrane IDA
IDA: 通过直接分析推断
24851274 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

S1PR3 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (56 - 298)

  • 0
  • 100
  • 200
  • 300
  • 378 a.a.
蛋白主名 其他名称

sphingosine 1-phosphate receptor 3

G protein-coupled receptor, endothelial differentiation gene-3

S1P receptor 3

S1P receptor EDG3

S1P receptor Edg-3

endothelial differentiation G-protein coupled receptor 3

endothelial differentiation, sphingolipid G-protein-coupled receptor, 3

sphingosine 1-phosphate receptor Edg-3

uncharacterized protein C9orf47

S1PR3 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
S1PR3 Q99500 ITGB4 Homo sapiens P16144
Anti Bait CoIP
24851274
种属间: 跨种属相互作用 种属内: 同种属相互作用

关联疾病

疾病名称 别名
Mouth Disease

Mouth Diseases

Mouth Disorders
Pulmonary Edema
Dermatitis, Atopic, 7

ATOD7

Dermatitis, Atopic, Susceptibility To, 7

Atopic Dermatitis 7

Dermatitis, Atopic 7
Basal Cell Carcinoma

Basal Cell Cancer

Basal Cell Neoplasm

Basal Cell Carcinoma Of Skin

Malignant Basal Cell Tumor

Basal Cell Tumor

Epithelioma Basal Cell

Malignant Basal Cell Neoplasm

Rodent Ulcer

Carcinoma Basal Cell

Neoplasms, Basal Cell

Basal Cell Carcinomas

Experimental Organism Basal Cell Carcinoma

Nodulo-Ulcerative Basal Cell Carcinoma

Basalioma

Basal Cell Epithelioma Of Skin

Bcc - [Basal Cell Carcinoma] Of Skin

Rodent Ulcer Of Skin

Rodent Ulcer Of Unspecified Site

Basal Cell Epithelioma Of Unspecified Site
Waardenburg Syndrome, Type 2b

Waardenburg Syndrome Type 2b

WS2B

Waardenburg Syndrome, Type Iib

Waardenburg Syndrome Type Iib
Second-Degree Atrioventricular Block

Second-Degree Heart Block

Second Degree Atrioventricular Block

Second Degree Atrioventricular Heart Block

Second Degree Heart Block

Incomplete Atrioventricular Block, Second Degree Nos

Second-Degree Block, Type 1 And 2

Atrioventricular Block, Type 1 And 2

Second Degree Incomplete Atrioventricular Block

Av - [Atrioventricular] Block 2nd
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (3)
目录号 产品名 作用方式
纯度 是否罕见病
HY-12355 Siponimod Agonist 99.95% 否
HY-10569 Ponesimod Agonist 99.81% 是
HY-12355A Siponimod hemifumarate Agonist / 否
Pre-clinical Phase
生物活性分子 (4)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-119401 CAY10444 Antagonist ≥98.0% 否
HY-111253 CYM-5478 Agonist 99.90% 否
HY-113934 L-threo Lysosphingomyelin (d18:1) Agonist ≥98.0% 否
HY-108492 TC-SP 14 Agonist / 否

直系同源

种属 基因名 来源 基因 ID
Rattus norvegicus S1PR3 RGD RGD:1583843
Bos taurus S1PR3 VGNC VGNC:34254
Mus musculus S1PR3 MGD MGI:1339365
Felis catus S1PR3 VGNC VGNC:64847
Canis familiaris S1PR3 VGNC VGNC:45837
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