2. Gene
  3. CPM - carboxypeptidase M Gene

CPM - carboxypeptidase M Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：羧肽酶 M

种属: Homo sapiens

基因 ID: 1368 | 基因类型: protein coding

关于 CPM

Cytogenetic location: 12q15 Genomic coordinates (GRCh38): 12:68,842,197-68,963,469 (from NCBI)

This gene has 13 transcripts (splice variants), 198 orthologues and 7 paralogues. Broad expression in fat (RPKM 56.0), lung (RPKM 21.3) and 19 other tissues.

功能概要

该基因编码的蛋白质是一种膜结合的精氨酸/赖氨酸羧肽酶。它的表达与单核细胞向巨噬细胞的分化有关。这种编码的蛋白质在氨基和羧基末端包含疏水区域，并具有 6 个潜在的天冬酰胺连接的糖基化位点。羧肽酶 A 和 B 的活性位点残基在该蛋白质中是保守的。已针对该基因描述了编码相同蛋白质的三种可变剪接转录物变体。[RefSeq 提供，2008 年 7 月]

The protein encoded by this gene is a membrane-bound arginine/lysine Carboxypeptidase. Its expression is associated with monocyte to macrophage differentiation. This encoded protein contains hydrophobic regions at the amino and carboxy termini and has 6 potential asparagine-linked glycosylation sites. The active site residues of carboxypeptidases A and B are conserved in this protein. Three alternatively spliced transcript variants encoding the same protein have been described for this gene. [provided by RefSeq, Jul 2008]

CPM 基因产物(21)

mRNA Protein Name
NM_001005502.3 NP_001005502.1 carboxypeptidase M isoform b precursor
NM_001413387.1 NP_001400316.1 carboxypeptidase M isoform a precursor
NM_001413388.1 NP_001400317.1 carboxypeptidase M isoform b precursor
NM_001413389.1 NP_001400318.1 carboxypeptidase M isoform b precursor
NM_001413390.1 NP_001400319.1 carboxypeptidase M isoform b precursor
NM_001413391.1 NP_001400320.1 carboxypeptidase M isoform b precursor
NM_001413392.1 NP_001400321.1 carboxypeptidase M isoform c
NM_001413393.1 NP_001400322.1 carboxypeptidase M isoform d precursor
NM_001413394.1 NP_001400323.1 carboxypeptidase M isoform d precursor
NM_001413395.1 NP_001400324.1 carboxypeptidase M isoform e
NM_001413396.1 NP_001400325.1 carboxypeptidase M isoform e
NM_001413397.1 NP_001400326.1 carboxypeptidase M isoform f
NM_001413398.1 NP_001400327.1 carboxypeptidase M isoform f
NM_001413399.1 NP_001400328.1 carboxypeptidase M isoform f
NM_001413400.1 NP_001400329.1 carboxypeptidase M isoform f
NM_001413401.1 NP_001400330.1 carboxypeptidase M isoform f
NM_001413402.1 NP_001400331.1 carboxypeptidase M isoform g precursor
NM_001413403.1 NP_001400332.1 carboxypeptidase M isoform h
NM_001413404.1 NP_001400333.1 carboxypeptidase M isoform h
NM_001874.5 NP_001865.1 carboxypeptidase M isoform b precursor
NM_198320.5 NP_938079.1 carboxypeptidase M isoform b precursor

CPM 蛋白结构

Peptidase_M14

Peptidase_M14: Zinc carboxypeptidase (28 - 302)

CarboxypepD_reg

CarboxypepD_reg: Carboxypeptidase regulatory-like domain (315 - 381)

  • 0
  • 100
  • 200
  • 300
  • 400
  • 443 a.a.
蛋白主名 其他名称

carboxypeptidase M

renal carboxypeptidase

重组 CPM 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7737 Carboxypeptidase M/CPM Protein, Human (HEK293, His) P14384 (L18-D421) ≥95%

关联疾病

疾病名称 别名
Lateral Medullary Syndrome

Posterior Inferior Cerebellar Artery Syndrome

Wallenberg Syndrome

Vertebral Artery Syndrome

Wallenberg'S Syndrome

Pica Syndrome
Esophagus Sarcoma

Esophageal Sarcoma
Breast Liposarcoma

Liposarcoma Of The Breast
Liposarcoma

Lipomatous Cancer
Pneumoconiosis

Pneumoconioses

Silicosis Nos

Complicated Silicosis

Fibrosis Of Lung With Silicosis

Nodular Silicosis

Pneumoconiosis Due To Silica

Silicotic Fibrosis Of Lung

Simple Silicosis

Silicatosis

Silicotic Lung Fibrosis

Pneumoconiosis Due To Talc

Pulmonary Talcosis

Talc Lung Disease

Talc Pneumoconiosis

Talc Workers' Pneumoconiosis

Talcosis

Fibrosis Of Lung Due To Talc

Asbestos Pneumoconiosis

Amianthosis

Asbestosis

Lung Fibrosis With Asbestosis

Pulmonary Asbestosis
Brain Stem Infarction

Brain Stem Infarctions

Brainstem Infarction
Well-Differentiated Liposarcoma

Atypical Lipomatous Tumor

Atypical Lipoma

Alt

Wdls

Liposarcoma, Well Differentiated

Pleomorphic Lipoma
Hereditary Angioedema

Hereditary Angioneurotic Edema

Hereditary Angioedema Type 1

Hane

Angioedema, Hereditary

Hae

Angioedemas, Hereditary

Deficiency Of C1 Esterase Inhibitor

C1 Esterase Inhibitor Deficiency

C1 Inhibitor Deficiency

Familial Angioneurotic Edema

Hereditary Bradykinine-Induced Angioedema

Hereditary Non Histamine-Induced Angioedema

Hae 1

Hae-I

Hereditary Angioneurotic Edema Type 1

Hereditary C1 Esterase Inhibitor Deficiency - Deficient Factor

Hereditary Angioedema Types I And Ii

Hereditary Angioneurotic Oedema

Familial Angioedema

Hae - [Hereditary Angioneurotic Oedema]

Bannister Disease, Hereditary

Quincke Disease Or Oedema

Hereditary Quincke Oedema
Cleft Palate, Isolated

Cleft Palate

Isolated Cleft Palate

CPI

Cp

Palatoschisis

Cleft Palate Isolated

Uranostaphyloschisis

Congenital Fissure Of Palate

Cleft Of Secondary Palate
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Approval
生物活性分子 (1)
目录号 产品名 作用方式
纯度 是否罕见病
HY-13010 Laquinimod 99.96% 是
Clinical Phase
生物活性分子 (1)
目录号 产品名 作用方式
纯度 Phase
HY-D0069 CPM ≥99.0% Phase 4
Pre-clinical Phase
生物活性分子 (6)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS03100 CPM Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-13010S Laquinimod-d5 Inhibitor 98.25% 否
HY-W062904 Laquinimod sodium Inhibitor / 否
HY-P10057 cpm-1285 Inducer / 否
HY-P10058 cpm-1285m / 否
HY-D2376 BH-Vis / 否

直系同源

种属 基因名 来源 基因 ID
Canis familiaris CPM VGNC VGNC:54521
Bos taurus CPM VGNC VGNC:27655
Mus musculus CPM MGD MGI:1917824
Rattus norvegicus CPM RGD RGD:1310532
Macaca mulatta CPM VGNC VGNC:71461
Felis catus CPM VGNC VGNC:61126
Others CPM NCBI
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