CRHBP - corticotropin releasing hormone binding protein Gene

中文名称：促肾上腺皮质激素释放激素结合蛋白

种属: Homo sapiens

同用名: CRFBP; CRF-BP

基因 ID: 1393 | 基因类型: protein coding

关于 CRHBP

Cytogenetic location: 5q13.3 Genomic coordinates (GRCh38): 5:76,953,045-76,981,159 (from NCBI)

This gene has 5 transcripts (splice variants) and 201 orthologues. Biased expression in liver (RPKM 36.1), kidney (RPKM 16.1) and 6 other tissues.

功能概要

促肾上腺皮质激素释放激素是前阿黑皮质素衍生肽合成和分泌的有效刺激剂。尽管人体外周循环中的 CRH 浓度通常较低，但它们在整个怀孕期间会增加并在分娩后迅速下降。母体血浆 CRH 可能来源于胎盘。人血浆含有一种 CRH 结合蛋白，可使 CRH 失活，并可防止妊娠期不适当的垂体-肾上腺刺激。[RefSeq 提供，2008 年 7 月]

Corticotropin-releasing hormone is a potent stimulator of synthesis and secretion of preopiomelanocortin-derived Peptides. Although CRH concentrations in the human peripheral circulation are normally low, they increase throughout pregnancy and fall rapidly after parturition. Maternal plasma CRH probably originates from the placenta. Human plasma contains a CRH-binding protein which inactivates CRH and which may prevent inappropriate pituitary-adrenal stimulation in pregnancy. [provided by RefSeq, Jul 2008]

CRHBP 基因产物(1)

mRNA	Protein	Name
NM_001882.4	NP_001873.2	corticotropin-releasing factor-binding protein precursor

基因本体论

分子功能
生物过程
细胞组分

分子功能 GO 注释	逻辑证据	参考文献	来源
enables corticotropin-releasing hormone binding	IDA IDA: 通过直接分析推断	1846945	GOA
enables corticotropin-releasing hormone binding	IPI IPI: 通过物理相互作用推断	18234674	GOA
enables protein binding	IPI IPI: 通过物理相互作用推断	18234674	GOA

生物过程 GO 注释	逻辑证据	参考文献	来源
involved in behavioral response to ethanol	IMP IMP: 通过突变表型推断	21039637	GOA
involved in cellular response to estradiol stimulus	IDA IDA: 通过直接分析推断	15345745	GOA
involved in cellular response to estrogen stimulus	IDA IDA: 通过直接分析推断	15345745	GOA
involved in cellular response to potassium ion	IDA IDA: 通过直接分析推断	21624661	GOA
involved in cellular response to tumor necrosis factor	IDA IDA: 通过直接分析推断	15345745	GOA
involved in female pregnancy	IDA IDA: 通过直接分析推断	18559919	GOA
involved in female pregnancy	IEP IEP: 通过表达模式推断	1846945	GOA
involved in hormone-mediated signaling pathway	IDA IDA: 通过直接分析推断	18234674	GOA
involved in inflammatory response	IDA IDA: 通过直接分析推断	18559919	GOA
involved in negative regulation of corticotropin secretion	IDA IDA: 通过直接分析推断	1846945	GOA
involved in negative regulation of corticotropin-releasing hormone receptor activity	IDA IDA: 通过直接分析推断	18234674	GOA
involved in regulated exocytosis	IDA IDA: 通过直接分析推断	21624661	GOA
involved in regulation of cellular response to stress	IMP IMP: 通过突变表型推断	21039637	GOA
involved in regulation of corticotropin secretion	IDA IDA: 通过直接分析推断	13150566	GOA

细胞组分 GO 注释	逻辑证据	参考文献	来源
NOT located in Golgi apparatus	IDA IDA: 通过直接分析推断	21624661	GOA
NOT located in endoplasmic reticulum	IDA IDA: 通过直接分析推断	21624661	GOA
located in extracellular space	IDA IDA: 通过直接分析推断	1846945	GOA
located in secretory granule	IDA IDA: 通过直接分析推断	21624661	GOA

EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

CRHBP 蛋白结构

CRF-BP

0
100
200
300
322 a.a.

蛋白主名

其他名称

corticotropin-releasing factor-binding protein

CRF-binding protein

重组 CRHBP 蛋白

目录号	产品名	蛋白编号	纯度
HY-P70013	CRHBP Protein, Human (HEK293, His)	P24387 (Y25-L322)	≥95%

关联疾病

疾病名称

别名

Major Depressive Disorder

Seasonal Affective Disorder	Unipolar Depression
Depression	MDD
Depressive Disorder	Unipolar Depression, Susceptibility To
Major Depressive Disorder 1	Major Depressive Disorder, Response To Citalopram Therapy In
Major Depressive Disorder 2	Winter Depression
Single Major Depressive Episode	Sad
Clinical Depression	Major Depression
Depressive Syndrome	Major Depressive Disorder And Accelerated Response To Antidepressant Drug Treatment
Seasonal Affective Disorder, Susceptibility To	Recurrent Major Depression
Affective Disorder, Seasonal	Depression In A Seasonal Pattern
Depression	Seasonal
Major Depressive Disorder With A Seasonal Pattern	Seasonal Depression
Seasonal Mood Disorder	Mental Depression
Recurrent Major Depressive Episodes

Hypoadrenocorticism, Familial

Addison Disease	Primary Adrenocortical Insufficiency
Addison'S Disease	Adrenal Gland Hypofunction
Adrenal Hypoplasia	Adrenal Aplasia
Addison Disease, Chronic Adrenal Insufficiency	Primary Hypoadrenalism
Hypoadrenocorticism Familial	Autoimmune Addison Disease
Autoimmune Adrenalitis	Classic Addison Disease
Primary Addison Disease	Addisons Disease
Addison Disease, Susceptibility To	Autoimmune Primary Adrenal Insufficiency
Addison'S Disease Due To Autoimmunity

Anxiety

Anxiety Disorder	Anxiety Disorders
Anxiety State	Anxieties
Anxiety Neurosis

Conn'S Syndrome

Cushing Syndrome	Hyperaldosteronism
Primary Hyperaldosteronism	Hypercortisolism
Primary Aldosteronism	Cushing'S Syndrome
Adrenal Gland Hyperfunction	Conn Syndrome
Hyperadrenalism	Ectopic Acth Syndrome
Hyperadrenocorticism	Cushing Disease
Cushing'S Disease	Adrenal Cortex Adenoma
Corticotroph Pituitary Adenoma	Pituitary Corticotroph Micro-Adenoma
Pituitary-Dependent Cushing Syndrome	Pituitary Acth Hypersecretion
Acth Syndrome, Ectopic	Acth-Secreting Pituitary Adenoma
Adrenal Hyperfunction Resulting From Pituitary Acth Excess	Ectopic Adrenocorticotropic Hormone Syndrome
Nodular Primary Adrenocortical Dysplasia	Pituitary Dependent Cushing Syndrome
Pituitary Cushing Syndrome	Pituitary-Dependant Cushing Syndrome
Pituitary-Dependant Hypercortisolism	Pituitary-Dependant Hypercortisolism Disorder
Aldosteronism Primary	Acth Syndrome Ectopic
Adrenal Cushing'S Syndrome	Adrenal Cortical Adenoma
Cushing Syndrome Nos	Cortisol Hypersecretion
Corticoadrenal Hypersecretion	Cushing Syndrome Secondary To Ectopic Acth-Secretion
Ectopic Cushing Syndrome	Hypercortisolism Due To Nonpituitary Tumour
Ectopic Acth - [Adrenocorticotropic Hormone] Secretion	Ectopic Acth - [Adrenocorticotropic Hormone] Secretion Causing Cushing Syndrome
Idiopathic Aldosteronism	Aldosteronism
Primary Aldosteronism Due To Bilateral Adrenal Hyperplasia	Primary Aldosteronism Due To Adrenal Hyperplasia

Bipolar Disorder

Bipolar Depression	Manic Disorder
Depression, Bipolar	Bipolar Disorder Manic Phase
Depressive-Manic Psych.	Manic Bipolar Affective Disorder
Manic Bipolar I Disorder	Manic Depression
Manic Depressive Disorder	Mixed Bipolar Disorder
Bipolar Affective Disorder	Bipolar Affective Psychosis
Bipolar Spectrum Disorder	Manic Depressive Illness
Depression Bipolar	Bipolar Disorder, Mixed
Major Affective Disorder	Major Affective Disorder 1
Major Affective Disorder 2

疾病名称	别名
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Cat. No.	产品名	作用方式	纯度	是否罕见病
HY-RS03167	CRHBP Human Pre-designed siRNA Set A	Pre-designed Sets	/	否

直系同源

种属	基因名	来源	基因 ID
Rattus norvegicus	CRHBP	RGD	RGD:2403
Felis catus	CRHBP	VGNC	VGNC:61177
Bos taurus	CRHBP	VGNC	VGNC:27708
Mus musculus	CRHBP	MGD	MGI:88497
Macaca mulatta	CRHBP	VGNC	VGNC:71491
Canis familiaris	CRHBP	VGNC	VGNC:39610
Others	CRHBP	NCBI

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

站点地图隐私声明

沪ICP备15051369号-4

上海工商

沪公网安备31011502019417

沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

CRHBP - corticotropin releasing hormone binding protein Gene

关于 CRHBP

功能概要

CRHBP 基因产物(1)

CRHBP 蛋白结构

重组 CRHBP 蛋白

关联疾病

直系同源

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CRHBP - corticotropin releasing hormone binding protein Gene

关于 CRHBP

功能概要

CRHBP 基因产物(1)

CRHBP 蛋白结构

重组 CRHBP 蛋白

关联疾病

相关产品

直系同源

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z