2. Gene
  3. ADORA3 - adenosine A3 receptor Gene

ADORA3 - adenosine A3 receptor Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：腺苷 A3 受体

种属: Homo sapiens

同用名: A3AR

基因 ID: 140 | 基因类型: protein coding

关于 ADORA3

Cytogenetic location: 1p13.2 Genomic coordinates (GRCh38): 1:111,499,429-111,503,633 (from NCBI)

This gene has 4 transcripts (splice variants), 272 orthologues and 3 paralogues. Broad expression in adrenal (RPKM 4.4), small intestine (RPKM 2.9) and 20 other tissues.

功能概要

该基因编码一种属于腺苷受体家族的蛋白质，腺苷受体是 G 蛋白偶联受体，参与多种细胞内信号通路和生理功能。由该基因编码的受体在心肌缺血期间介导持续的心脏保护功能，它参与抑制嗜中性粒细胞介导的组织损伤中的嗜中性粒细胞脱颗粒，它与神经保护和神经退行性作用有关，它还可能介导细胞增殖和细胞死亡。可变剪接导致多个转录本变体。该基因与重叠 GeneID:57413 的一些转录物共享其 5' 末端外显子，后者编码含有免疫球蛋白结构域的蛋白质。[RefSeq 提供，2014 年 11 月]

This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014]

ADORA3 基因产物(3)

mRNA Protein Name
NM_000677.4 NP_000668.1 adenosine receptor A3 isoform A
NM_001302678.2 NP_001289607.1 adenosine receptor A3 isoform B
NM_001302679.2 NP_001289608.1 adenosine receptor A3 isoform C
基因本体论
  • 生物过程
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in negative regulation of NF-kappaB transcription factor activity IMP
IMP: 通过突变表型推断
27886186 GOA
involved in negative regulation of cell migration IMP
IMP: 通过突变表型推断
27886186 GOA
involved in negative regulation of cell population proliferation IMP
IMP: 通过突变表型推断
27886186 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

ADORA3 蛋白结构

7tm_1

7tm_1: 7 transmembrane receptor (rhodopsin family) (29 - 282)

  • 0
  • 100
  • 200
  • 300
  • 318 a.a.
蛋白主名 其他名称

adenosine receptor A3

关联疾病

疾病名称 别名
Exfoliation Syndrome

Pseudoexfoliation Glaucoma

Pseudoexfoliation Syndrome

Exfoliation Syndrome, Susceptibility To

XFS

Exfoliation Glaucoma

Xfg

Pseudoexfoliation Of The Lens

Pexg

Pexs

Exfoliative Syndrome

Glaucoma Capsulare

Pex

Pseudo-Exfoliation Syndrome
Migraine With Or Without Aura 1

Migraine

Migraine With Or Without Aura, Susceptibility To, 1

Migraine Disorder

Migraine Variant

Migraines

Migraine Disorders

Mgr1

Mgau

Ma

Migraine With Or Without Aura

Classic Migraine

Common Migraine

Disorder, Migraine

Headache Migraine

Headache Migrainous

Migraine Headache

Migraine Syndrome

Headache Including Migraine

Migraine, Susceptibility To
Ischemia

Acute Coronary Syndrome
Myocardial Stunning
Dermatitis, Atopic, 7

ATOD7

Dermatitis, Atopic, Susceptibility To, 7

Atopic Dermatitis 7

Dermatitis, Atopic 7
Nervous System Disease

Abnormality Of The Nervous System

Nervous System Diseases

Nervous System Disorder
Stroke, Ischemic

Cerebral Infarction

Stroke

Ischemic Stroke

Cerebrovascular Accident

Cerebral Infarction, Susceptibility To

Stroke, Ischemic, Susceptibility To

Cerebral Infarct

Ischemic Stroke, Susceptibility To

Stroke, Susceptibility To

Cva - Cerebral Infarction

ISCHSTR

Ischemic Cerebrovascular Accident
Intraocular Pressure Quantitative Trait Locus

Glaucoma

IOPQTL

Glaucoma, Susceptibility To

Postinfectious Glaucoma

Glaucoma With Ocular Inflammation

Glaucoma Secondary To Eye Inflammation

Traumatic Glaucoma

Glaucoma With Concussion Of Globe

Glaucoma Due To Ocular Trauma

Glaucoma Associated With Ocular Trauma

Glaucoma Secondary To Drugs
Subacute Leukemia
Vasculogenic Impotence

Impotence, Vasculogenic
Asthma

Chronic Obstructive Asthma

Asthma, Diminished Response To Antileukotriene Treatment In

Bronchial Hyperreactivity

Asthma, Susceptibility To

Asthma, Bronchial

Asthma, Protection Against

Asthma, Nocturnal, Susceptibility To

Nocturnal Asthma

Asthma-Related Traits

Asthma-Related Traits, Susceptibility To

Asthma, Nocturnal

Chronic Obstructive Asthma With Acute Exacerbation

Chronic Obstructive Asthma With Status Asthmaticus

Exercise Induced Asthma

Exercise-Induced Asthma

Bronchial Asthma

Asthma, Exercise-Induced

Idiosyncratic Asthma

Unspecified Asthma With Acute Exacerbation

Asthma, Unspecified, With Stated Status Asthmaticus

Status Asthmaticus Nos

Acute Severe Asthma

Acute Severe Bronchial Asthma

Status Asthma

Status Post Asthmaticus
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (3)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS00400 ADORA3 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00401 Adora3 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS00402 ADORA3 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Bos taurus ADORA3 VGNC VGNC:54876
Mus musculus ADORA3 MGD MGI:104847
Canis familiaris ADORA3 VGNC VGNC:37668
Rattus norvegicus ADORA3 RGD RGD:2051
Felis catus ADORA3 VGNC VGNC:59650
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