2. Gene
  3. Bmpr2 - bone morphogenetic protein receptor type 2 Gene

Bmpr2 - bone morphogenetic protein receptor type 2 Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

中文名称：骨形态发生蛋白受体 2 型

种属: Rattus norvegicus

同用名: Bmpr-II

基因 ID: 140590 | 基因类型: protein coding

关于 Bmpr2

Primary_assembly 9: 61,190,566-61,301,809 forward strand.mRatBN7.2:CM026982.1

This gene has 2 transcripts (splice variants), 265 orthologues, 11 paralogues and is associated with 24 phenotypes. Biased expression in Lung (RPKM 976.5), Heart (RPKM 288.5) and 8 other tissues.

功能概要

该基因编码的蛋白可启动生长因子结合活性。参与相机型眼的大脑发育和视网膜发育。位于几种细胞成分中，包括顶端质膜；基底质膜；和小窝。用于研究肺动脉高压。肺动脉高压的生物标志物。该基因的人类直系同源物与心脏间隔缺损有关；原发性肺动脉高压;肺动脉高压;和肺静脉闭塞性疾病。与人类 BMPR2（骨形态发生蛋白受体 2 型）同源。 [由基因组资源联盟提供，2022 年 4 月]

Enables growth factor binding activity. Involved in brain development and retina development in camera-type eye. Located in several cellular components, including apical plasma membrane; basal plasma membrane; and caveola. Used to study pulmonary hypertension. Biomarker of pulmonary hypertension. Human ortholog(s) of this gene implicated in heart septal defect; primary pulmonary hypertension; pulmonary hypertension; and pulmonary venoocclusive disease. Orthologous to human BMPR2 (bone morphogenetic protein receptor type 2). [provided by Alliance of Genome Resources, Apr 2022]

Bmpr2 基因产物(1)

mRNA Protein Name
NM_080407.1 NP_536332.1 bone morphogenetic protein receptor type-2 precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables growth factor binding IDA
IDA: 通过直接分析推断
11044210 RGD
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in retina development in camera-type eye IEP
IEP: 通过表达模式推断
10482474 RGD
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in apical plasma membrane IDA
IDA: 通过直接分析推断
16271518 RGD
located in basal plasma membrane IDA
IDA: 通过直接分析推断
16271518 RGD
located in caveola IDA
IDA: 通过直接分析推断
16271518 RGD
located in dendrite IDA
IDA: 通过直接分析推断
21185359 RGD
located in neuronal cell body IDA
IDA: 通过直接分析推断
21185359 RGD
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

Bmpr2 蛋白结构

Activin_recp

Activin_recp: pfam01064 (59 - 140)

STKc_BMPR2_AMHR2

STKc_BMPR2_AMHR2: cd14054 (220 - 517)

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  • 1052 a.a.
蛋白主名 其他名称

bone morphogenetic protein receptor type-2

bone morphogenetic protein receptor type II

bone morphogenetic protein receptor, type II (serine/threonine kinase)

bone morphogenic protein receptor, type II (serine/threonine kinase)

相关产品

Pre-clinical Phase
生物活性分子 (7)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-15897 LDN-212854 Inhibitor 99.70% 否
HY-154970A BMPR2-IN-1 TFA Inhibitor 99.40% 否
HY-154970 BMPR2-IN-1 Inhibitor / 否
HY-164145 CDD-1653 / 否
HY-RS01552 BMPR2 Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01553 Bmpr2 Mouse Pre-designed siRNA Set A Pre-designed Sets / 否
HY-RS01554 Bmpr2 Rat Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Bmpr2 NCBI NCBI:659
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