2. Gene
  3. SERPINA12 - serpin family A member 12 Gene

SERPINA12 - serpin family A member 12 Gene

  • 基因
  • 蛋白
  • 疾病
  • 相关产品
  • 直系同源

中文名称：serpin 家族成员 12

种属: Homo sapiens

同用名: OL-64

基因 ID: 145264 | 基因类型: protein coding

关于 SERPINA12

Cytogenetic location: 14q32.13 Genomic coordinates (GRCh38): 14:94,487,279-94,517,844 (from NCBI)

This gene has 3 transcripts (splice variants), 88 orthologues, 36 paralogues and is associated with 1 phenotype. Restricted expression toward skin (RPKM 63.5).

功能概要

预测可启用丝氨酸型内肽酶抑制剂活性。预测参与内肽酶活性的负调节。预计在糖异生的负调节上游或负调节内起作用；信号转导的正调控；和脂质代谢过程的调节。预测位于质膜中。预计在细胞外空间活跃。 [由基因组资源联盟提供，2022 年 4 月]

Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within negative regulation of gluconeogenesis; positive regulation of signal transduction; and regulation of lipid metabolic process. Predicted to be located in plasma membrane. Predicted to be active in extracellular space. [provided by Alliance of Genome Resources, Apr 2022]

SERPINA12 基因产物(3)

mRNA Protein Name
NM_001304461.2 NP_001291390.1 serpin A12 precursor
NM_001382267.1 NP_001369196.1 serpin A12 precursor
NM_173850.4 NP_776249.1 serpin A12 precursor
基因本体论
  • 分子功能
分子功能 GO 注释 逻辑证据 参考文献 来源
enables molecular function inhibitor activity IMP
IMP: 通过突变表型推断
23370777 GOA
enables protein binding IPI
IPI: 通过物理相互作用推断
28514442 GOA
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断

SERPINA12 蛋白结构

Serpin

Serpin: Serpin (serine protease inhibitor) (51 - 411)

  • 0
  • 100
  • 200
  • 300
  • 414 a.a.
蛋白主名 其他名称

serpin A12

serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 12

SERPINA12 蛋白互作信息

分类
蛋白名称 蛋白编号 互作蛋白 互作蛋白种属 互作蛋白编号 实验方法 参考文献
种属内
SERPINA12 Q8IW75 LAMB1 Homo sapiens P07942
Anti Tag CoIP
33961781
种属内
SERPINA12 Q8IW75 LAMB1 Homo sapiens P07942
Anti Tag CoIP
28514442
种属间: 跨种属相互作用 种属内: 同种属相互作用

重组 SERPINA12 蛋白

目录号 产品名 蛋白编号 纯度
HY-P7419 Vaspin Protein, Human Q8IW75 (L21-K414) ≥95%
HY-P71299 Vaspin Protein, Human (GST) Q8IW75 (L21-K414) ≥95%
HY-P71300 Vaspin Protein, Human (HEK293, His) Q8IW75 (L21-K414) ≥95%

关联疾病

疾病名称 别名
Palmoplantar Keratoderma, Norrbotten Recessive Type

PPKNR

Hereditary Palmoplantar Keratoderma, Gamborg-Nielsen Type

Hereditary Palmoplantar Hyperkeratosis, Gamborg-Nielsen Type

Ppk, Gamborg-Nielsen Type

Keratoderma, Palmoplantar, Norrbotten Recessive Type
Carotid Stenosis

Carotid Artery Stenosis

Stenosis, Carotid Artery
Type 2 Diabetes Mellitus

Insulin Resistance

NIDDM

Type 2 Diabetes

Diabetes Mellitus, Non-Insulin-Dependent

T2D

Noninsulin-Dependent Diabetes Mellitus

Diabetes Mellitus, Type Ii

Maturity-Onset Diabetes

Insulin Resistance, Severe, Digenic

Diabetes Mellitus, Type 2

Diabetes Mellitus, Noninsulin-Dependent

Diabetes Mellitus, Noninsulin-Dependent, Association With

Diabetes Mellitus, Noninsulin-Dependent, Late Onset

Hypertension, Insulin Resistance-Related, Susceptibility To

Insulin Resistance, Susceptibility To

Non-Insulin-Dependent Diabetes Mellitus

Type Ii Diabetes Mellitus

Adult-Onset Diabetes Mellitus

Maturity-Onset Diabetes Mellitus

Diabetes Mellitus Type 2

Type Ii Diabetes

Type 2 Diabetes Mellitus, Susceptibility To

Diabetes, Type 2

Diabetes Mellitus, Noninsulin-Dependent, Susceptibility To

Diabetes Mellitus, Non-Insulin-Dependent, Susceptibility To

Diabetes Mellitus, Type 2, Susceptibility To

Diabetes Mellitus, Noninsulin-Dependent, 2

Diabetes Mellitus, Type Ii, Susceptibility To

Hypertension, Insulin Resistance-Related

Adult-Onset Diabetes

Aodm

Diabetes Mellitus, Adult-Onset

Diabetes Mellitus Type Ii

Diabetes Mellitus Type 2, Susceptibility To

Diabetes, Type Ii, Susceptibility To

Diabetes Type 2

Diabetes Mellitus

Adult Onset Diabetes

Maturity Onset Diabetes

Nonketotic Diabetes

Non-Insulin Dependent Diabetes Mellitus

T2dm - [Type 2 Diabetes Mellitus]

Niddm - [Non Insulin Dependent Diabetes Mellitus]

Dm2

Dm Type Ii

Diabetic Type 2

Insulin Requiring Type 2 Diabetes

Noninsulin Dependent Diabetes

Non-Insulin-Dependent Diabetes Mellitus Without Complications

Diabetes Due To Insulin Secretory Defect

Diabetes Mellitus Due To Insulin Secretory Defect

Non-Insulin-Dependent Diabetes Of The Young

Senile Diabetes

Nonketotic Hyperglycaemia

Stable Diabetes
Body Mass Index Quantitative Trait Locus 11

OBESITY

Obesity, Susceptibility To

Leanness, Inherited

Obesity, Susceptibility To, Bmiq11

Obesity, Mild, Early-Onset

Obesity, Association With

Obesity, Early-Onset, Susceptibility To

Obesity, Severe

Obesity, Severe, And Type Ii Diabetes

Obesity, Late-Onset

Obesity , Susceptibility To

BMIQ11

Obesity Bmiq11

Obesity, Early-Onset

Simple Obesity Nos

Excess Fat

Obesity, Not Elsewhere Classified, Body Mass Index Not Elsewhere Classified

Adiposis
Amelogenesis Imperfecta

Ai

Congenital Enamel Hypoplasia

Al - [Amelogenesis Imperfecta]
Diabetes Mellitus

Diabetes
疾病名称 别名
Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

Waldenstroem'S Macroglobulinemia

Waldenstroem'S Macroglobulinemia

Macroglobulinemia Of Waldenstrom

Lymphoplasmacytic Lymphoma With Igm Gammopathy

Lymphoplasmacytic Lymphoma

相关产品

Pre-clinical Phase
生物活性分子 (1)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS12698 SERPINA12 Human Pre-designed siRNA Set A Pre-designed Sets / 否

直系同源

种属 基因名 来源 基因 ID
Macaca mulatta SERPINA12 VGNC VGNC:77266
Felis catus SERPINA12 VGNC VGNC:65022
Mus musculus SERPINA12 MGD MGI:1915304
Rattus norvegicus SERPINA12 RGD RGD:708485
Canis familiaris SERPINA12 VGNC VGNC:51682
Others SERPINA12 NCBI
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