2. Gene
  3. Grn - granulin Gene

Grn - granulin Gene

  • 基因
  • 蛋白
  • 相关产品
  • 直系同源

种属: Mus musculus

同用名: GP88; PEPI; Pgrn; PCDGF; epithelin

基因 ID: 14824 | 基因类型: protein coding

关于 Grn

功能概要

Predicted to enable chaperone binding activity. Involved in several processes, including astrocyte activation involved in immune response; positive regulation of cellular component organization; and regulation of defense response. Acts upstream of or within several processes, including blastocyst hatching; locomotory exploration behavior; and lysosomal protein catabolic process. Located in several cellular components, including endoplasmic reticulum; lysosome; and trans-Golgi network. Is expressed in several structures, including early conceptus; gonad; integument; nervous system; and placenta. Used to study Grn-related frontotemporal lobar degeneration with Tdp43 inclusions and nephrogenic diabetes insipidus. Human ortholog(s) of this gene implicated in dementia (multiple); neurodegenerative disease (multiple); neuronal ceroid lipofuscinosis 11; and primary progressive multiple sclerosis. Orthologous to human GRN (granulin precursor). [provided by Alliance of Genome Resources, Apr 2022]

Grn 基因产物(1)

mRNA Protein Name
NM_008175.5 NP_032201.3 progranulin precursor
基因本体论
  • 分子功能
  • 生物过程
  • 细胞组分
分子功能 GO 注释 逻辑证据 参考文献 来源
enables protein binding IPI
IPI: 通过物理相互作用推断
12526812 MGI
生物过程 GO 注释 逻辑证据 参考文献 来源
involved in astrocyte activation involved in immune response IMP
IMP: 通过突变表型推断
20026663 MGI
acts upstream of or within blastocyst hatching IDA
IDA: 通过直接分析推断
15901638 MGI
acts upstream of or within embryo implantation IDA
IDA: 通过直接分析推断
15901638 MGI
acts upstream of epithelial cell proliferation IDA
IDA: 通过直接分析推断
15901638 MGI
acts upstream of or within locomotory exploration behavior IMP
IMP: 通过突变表型推断
28728022 MGI
acts upstream of or within lysosomal protein catabolic process IMP
IMP: 通过突变表型推断
28728022 MGI
involved in lysosomal transport IMP
IMP: 通过突变表型推断
28541286 MGI
involved in lysosome organization IMP
IMP: 通过突变表型推断
27789271 MGI
involved in maintenance of synapse structure IDA
IDA: 通过直接分析推断
29398357 MGI
involved in maintenance of synapse structure IMP
IMP: 通过突变表型推断
29398357 MGI
involved in microglial cell activation involved in immune response IMP
IMP: 通过突变表型推断
20026663 MGI
acts upstream of or within negative regulation of hydrolase activity IMP
IMP: 通过突变表型推断
28728022 MGI
involved in negative regulation of inflammatory response IMP
IMP: 通过突变表型推断
20026663 MGI
involved in negative regulation of innate immune response IMP
IMP: 通过突变表型推断
20026663 MGI
involved in negative regulation of microglial cell activation IMP
IMP: 通过突变表型推断
23041626 MGI
involved in positive regulation of angiogenesis IDA
IDA: 通过直接分析推断
12524533 MGI
involved in positive regulation of aspartic-type peptidase activity IMP
IMP: 通过突变表型推断
28453791 MGI
involved in positive regulation of axon regeneration IMP
IMP: 通过突变表型推断
28453791 MGI
involved in positive regulation of cell population proliferation IDA
IDA: 通过直接分析推断
12524533 MGI
involved in positive regulation of defense response to bacterium IMP
IMP: 通过突变表型推断
20026663 MGI
involved in positive regulation of endothelial cell migration IDA
IDA: 通过直接分析推断
12524533 MGI
acts upstream of or within positive regulation of epithelial cell proliferation IDA
IDA: 通过直接分析推断
15901638 MGI
involved in positive regulation of inflammatory response to wounding IDA
IDA: 通过直接分析推断
12524533 MGI
involved in positive regulation of lysosome organization IDA
IDA: 通过直接分析推断
28073925 MGI
involved in positive regulation of neuron apoptotic process IMP
IMP: 通过突变表型推断
23041626 MGI
involved in positive regulation of protein folding IMP
IMP: 通过突变表型推断
27789271 MGI
acts upstream of or within positive regulation of trophectodermal cell proliferation IDA
IDA: 通过直接分析推断
15901638 MGI
acts upstream of or within regulation of lysosome organization IMP
IMP: 通过突变表型推断
28728022 MGI
acts upstream of or within retina development in camera-type eye IMP
IMP: 通过突变表型推断
28728022 MGI
acts upstream of trophectodermal cell proliferation IDA
IDA: 通过直接分析推断
15901638 MGI
细胞组分 GO 注释 逻辑证据 参考文献 来源
located in Golgi apparatus IDA
IDA: 通过直接分析推断
27789271 MGI
is active in cerebellar climbing fiber to Purkinje cell synapse IDA
IDA: 通过直接分析推断
29398357 MGI
is active in cerebellar climbing fiber to Purkinje cell synapse IMP
IMP: 通过突变表型推断
29398357 MGI
located in endoplasmic reticulum IDA
IDA: 通过直接分析推断
27789271 MGI
located in extracellular region IDA
IDA: 通过直接分析推断
28073925 MGI
located in extracellular space IDA
IDA: 通过直接分析推断
15901638 MGI
located in lysosome IDA
IDA: 通过直接分析推断
27789271 MGI
located in trans-Golgi network IDA
IDA: 通过直接分析推断
27789271 MGI
located in vesicle IDA
IDA: 通过直接分析推断
28453791 MGI
EXP：通过实验结果推断 IDA：通过直接分析推断 IPI：通过物理相互作用推断 IMP：通过突变表型推断 IGI：通过遗传相互作用推断 IEP：通过表达模式推断
蛋白主名 其他名称

progranulin

PC cell-derived growth factor

acrogranin

acrogranulin

epithelin/granulin

glycoprotein 88

glycoprotein of 88 Kda

granulins

proepithelin

重组 Grn 蛋白

目录号 产品名 蛋白编号 纯度
HY-P74617 Progranulin/PGRN Protein, Mouse (HEK293, His, solution) P28798 (T18-L589) ≥95%
HY-P78302 Progranulin/PGRN Protein, Mouse (HEK293, His) P28798 (T18-L589) ≥95%

相关产品

Clinical Phase
抗体抑制剂 (1)
目录号 产品名 作用方式
纯度 Phase
HY-P99688 Latozinemab Inhibitor 95.00% Phase 3
Pre-clinical Phase
生物活性分子 (2)
Cat. No. 产品名 作用方式
纯度 是否罕见病
HY-RS05843 GRN Human Pre-designed siRNA Set A Pre-designed Sets / 否
HY-124393 GRN-529 Modulator / 否

直系同源

种属 基因名 来源 基因 ID
Homo sapiens Grn NCBI NCBI:2896
Rattus norvegicus Grn NCBI NCBI:29143
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